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Coca
Coca
is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. The plant is grown as a cash crop in Argentina, Bolivia, Colombia, Ecuador, and Peru, even in areas where its cultivation is unlawful.[2] There are some reports that the plant is being cultivated in the south of Mexico
Mexico
as a cash crop and an alternative to smuggling its recreational product cocaine.[3] It also plays a role in many traditional Andean cultures as well as the Sierra Nevada de Santa Marta (see Traditional uses). Coca
Coca
is known throughout the world for its psychoactive alkaloid, cocaine. The alkaloid content of coca leaves is relatively low, between 0.25% and 0.77%.[4] The native people use it for a stimulant, like coffee, or an energy source or both. Coca-Cola
Coca-Cola
used coca leaf extract in its products from 1885 and until about 1903.[5][6] Extraction of cocaine from coca requires several solvents and a chemical process known as an acid / base extraction, which can fairly easily extract the alkaloids from the plant.

Contents

1 Description 2 Species and evolution

2.1 Herbicide
Herbicide
resistant varieties

3 Cultivation 4 Pharmacological aspects 5 History 6 Traditional uses

6.1 Medicine 6.2 Nutrition 6.3 Religion 6.4 Traditional preparation

6.4.1 Chew 6.4.2 Tea

7 Commercial and industrial uses

7.1 New markets

8 Literary references 9 International prohibition of coca leaf 10 Legal status

10.1 Netherlands 10.2 United States 10.3 Canada 10.4 Australia

11 See also 12 References 13 External links

Description[edit] The coca plant resembles a blackthorn bush, and grows to a height of 2 to 3 metres (7 to 10 feet). The branches are straight, and the leaves are thin, opaque, oval, and taper at the extremities. A marked characteristic of the leaf is an areolated portion bounded by two longitudinal curved lines, one line on each side of the midrib, and more conspicuous on the under face of the leaf. The flowers are small, and disposed in clusters on short stalks; the corolla is composed of five yellowish-white petals, the anthers are heart-shaped, and the pistil consists of three carpels united to form a three-chambered ovary. The flowers mature into red berries. The leaves are sometimes eaten by the larvae of the moth Eloria noyesi. Species and evolution[edit] There are two species of cultivated coca, each with two varieties:

Erythroxylum coca

Erythroxylum coca
Erythroxylum coca
var. coca (Bolivian or Huánuco
Huánuco
Coca) – well adapted to the eastern Andes
Andes
of Peru
Peru
and Bolivia, an area of humid, tropical, montane forest. Erythroxylum coca
Erythroxylum coca
var. ipadu (Amazonian Coca) – cultivated in the lowland Amazon Basin
Amazon Basin
in Peru
Peru
and Colombia.

Erythroxylum novogranatense

Erythroxylum novogranatense
Erythroxylum novogranatense
var. novogranatense (Colombian Coca) – a highland variety that is utilized in lowland areas. It is cultivated in drier regions found in Colombia. However, E. novogranatense is very adaptable to varying ecological conditions. The leaves have parallel lines on either side of the central vein. Erythroxylum novogranatense
Erythroxylum novogranatense
var. truxillense (Trujillo Coca) – grown primarily in Peru
Peru
and Colombia. the leaves of E. novogranatense var. truxillense does not have parallel lines on either side of the central vein like all other varieties.

All four of the cultivated cocas were domesticated in pre-Columbian times and are more closely related to each other than to any other species.[2] There are two main theories relating to the evolution of the cultivated cocas. The first (put forth by Plowman[7] and Bohm[8]) suggests that Erythroxylum coca
Erythroxylum coca
var. coca is ancestral, while Erythroxylum novogranatense
Erythroxylum novogranatense
var. truxillense is derived from it to be drought tolerant, and Erythroxylum novogranatense
Erythroxylum novogranatense
var. novogranatense derived from Erythroxylum novogranatense
Erythroxylum novogranatense
var. truxillense. Recent research based on genetic evidence (Johnson et al. in 2005,[9] Emche et al. in 2011,[10] and Islam 2011[11]) does not support this linear evolution and instead suggests a second domestication event as the origin of the Erythroxylum novogranatense
Erythroxylum novogranatense
varieties. There may be a common, but undiscovered ancestor.[10] Wild populations of Erythroxylum coca
Erythroxylum coca
var. coca are found in the eastern Andes; the other 3 taxa are only known as cultivated plants. The two subspecies of Erythroxylum coca
Erythroxylum coca
are almost indistinguishable phenotypically. Erythroxylum novogranatense
Erythroxylum novogranatense
var. novogranatense and Erythroxylum novogranatense
Erythroxylum novogranatense
var. truxillense are phenotypically similar, but morphologically distinguishable. Under the older Cronquist system
Cronquist system
of classifying flowering plants, this was placed in an order Linales; more modern systems place it in the order Malpighiales. Herbicide
Herbicide
resistant varieties[edit] Also known as supercoca or la millionaria, Boliviana negra
Boliviana negra
is a relatively new form of coca that is resistant to a herbicide called glyphosate. Glyphosate
Glyphosate
is a key ingredient in the multibillion-dollar aerial coca eradication campaign undertaken by the government of Colombia
Colombia
with U.S. financial and military backing known as Plan Colombia. The herbicide resistance of this strain has at least two possible explanations: that a "peer-to-peer" network of coca farmers used selective breeding to enhance this trait through tireless effort, or the plant was genetically modified in a laboratory. In 1996, a patented glyphosate-resistant soybean was marketed by Monsanto Company, suggesting that it would be possible to genetically modify coca in an analogous manner. Spraying Boliviana negra
Boliviana negra
with glyphosate would serve to strengthen its growth by eliminating the non-resistant weeds surrounding it. Joshua Davis, in the Wired article cited below, found no evidence of CP4 EPSPS, a protein produced by the glyphosate-resistant soybean, suggesting Bolivana negra was either created in a lab by a different technique or bred in the field.[12][13] Cultivation[edit]

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See also: Coca
Coca
production in Colombia

Coca
Coca
tree in Colombia

Coca
Coca
is traditionally cultivated in the lower altitudes of the eastern slopes of the Andes
Andes
(the Yungas), or the highlands depending on the species grown. Coca
Coca
production begins in the valleys and upper jungle regions of the Andean region, where the countries of Colombia, Peru and Bolivia
Bolivia
are host to more than 98 per cent of the global land area planted with coca.[14] Coca
Coca
plantations have also recently been discovered in Mexico, which could have major implications for the illegal cultivation of the plant.[15] The seeds are sown from December to January in small plots (almacigas) sheltered from the sun, and the young plants when at 40 to 60 centimetres (16 to 24 inches) in height are placed in final planting holes (aspi), or if the ground is level, in furrows (uachos) in carefully weeded soil. The plants thrive best in hot, damp and humid locations, such as the clearings of forests; but the leaves most preferred are obtained in drier areas, on the hillsides. The leaves are gathered from plants varying in age from one and a half to upwards of forty years, but only the new fresh growth is harvested. They are considered ready for plucking when they break on being bent. The first and most abundant harvest is in March after the rainy season, the second is at the end of June, and the third in October or November. The green leaves (matu) are spread in thin layers on coarse woollen cloths and dried in the sun; they are then packed in sacks, which must be kept dry in order to preserve the quality of the leaves.

Morphology of the coca plant

Leaves 

Leaves and fruit 

Leaves and branches 

Pharmacological aspects[edit]

Benzoylmethylecgonine, the psychoactive constituent of coca

The pharmacologically active ingredient of coca is the cocaine alkaloid, which is found in the amount of about 0.3 to 1.5%, averaging 0.8%,[16] in fresh leaves. Besides cocaine, the coca leaf contains a number of other alkaloids, including methylecgonine cinnamate, benzoylecgonine, truxilline, hydroxytropacocaine, tropacocaine, ecgonine, cuscohygrine, dihydrocuscohygrine, nicotine, and hygrine.[17] When chewed, coca acts as a mild stimulant and suppresses hunger, thirst, pain, and fatigue.[18][19] Absorption of coca from the leaf is less rapid than nasal application of purified forms of the alkaloid (almost all of the coca alkaloid is absorbed within 20 minutes of nasal application,[20] while it takes 2–12 hours after ingestion of the raw leaf for alkaline concentrations to peak.[21]). When the raw leaf is consumed in tea, between 59 and 90% of the coca alkaloid is absorbed.[22] The coca leaf, when consumed in its natural form, does not induce a physiological or psychological dependence, nor does abstinence after long-term use produce symptoms typical to substance addiction.[23][24] Due to its alkaloid content and non-addictive properties, coca has been suggested as a method to help recovering cocaine addicts to wean off the drug.[25][26] History[edit]

Coquero (Figure Chewing Coca), 850–1500 C.E. Brooklyn Museum

Workers in Java
Java
prepared coca leaves. This product was mainly traded in Amsterdam, and was further processed into cocaine. (Dutch East Indies, before 1940.)

Traces of coca have been found in mummies dating 3000 years back.[27] Other evidence dates the communal chewing of coca with lime 8000 years back.[28] Beginning with the Valdivian culture, circa 3000 BC, there is an unbroken record of coca leaf consumption by succeeding cultural groups on the coast of Ecuador
Ecuador
until European arrival as shown in their ceramic sculpture and abundant caleros or lime pots. Coca consumption among the North Coast Peruvian tribes begins around 2000 BC as evidenced by the caleros found by Junius Bird at Huaca Prieta and the emergence of dedicated lime containers in the Jetetepeque river valley. Extensive archaeological evidence for the chewing of coca leaves dates back at least to the 6th century AD Moche period, and the subsequent Inca
Inca
period, based on mummies found with a supply of coca leaves, pottery depicting the characteristic cheek bulge of a coca chewer, spatulas for extracting alkali and figured bags for coca leaves and lime made from precious metals, and gold representations of coca in special gardens of the Inca
Inca
in Cuzco.[29][30] Coca
Coca
chewing may originally have been limited to the eastern Andes before its introduction to the Inca. As the plant was viewed as having a divine origin, its cultivation became subject to a state monopoly and its use restricted to nobles and a few favored classes (court orators, couriers, favored public workers, and the army) by the rule of the Topa Inca
Inca
(1471–1493). As the Incan empire declined, the leaf became more widely available. After some deliberation, Philip II of Spain issued a decree recognizing the drug as essential to the well-being of the Andean Indians but urging missionaries to end its religious use. The Spanish are believed to have effectively encouraged use of coca by an increasing majority of the population to increase their labor output and tolerance for starvation, but it is not clear that this was planned deliberately.[citation needed] Coca
Coca
was first introduced to Europe in the 16th century, but did not become popular until the mid-19th century, with the publication of an influential paper by Dr. Paolo Mantegazza praising its stimulating effects on cognition. This led to invention of coca wine and the first production of pure cocaine. Coca wine
Coca wine
(of which Vin Mariani
Vin Mariani
was the best-known brand) and other coca-containing preparations were widely sold as patent medicines and tonics, with claims of a wide variety of health benefits. The original version of Coca-Cola
Coca-Cola
was among these. These products became illegal in most countries outside of South America in the early 20th century, after the addictive nature of cocaine was widely recognized. In 1859, Albert Niemann of the University of Göttingen
University of Göttingen
became the first person to isolate the chief alkaloid of coca, which he named "cocaine".[31] In the early 20th century, the Dutch colony of Java
Java
became a leading exporter of coca leaf. By 1912 shipments to Amsterdam, where the leaves were processed into cocaine, reached 1000 tons, overtaking the Peruvian export market. Apart from the years of the First World War, Java
Java
remained a greater exporter of coca than Peru
Peru
until the end of the 1920s.[32] Other colonial powers also tried to grow coca (including the British in India), but with the exception of the Japanese in Formosa, these were relatively unsuccessful.[32] In recent times (2006), the governments of several South American countries, such as Peru, Bolivia
Bolivia
and Venezuela, have defended and championed the traditional use of coca, as well as the modern uses of the leaf and its extracts in household products such as teas and toothpaste. The coca plant was also the inspiration for Bolivia's Coca Museum. Traditional uses[edit]

Man holding coca leaf in Bolivia

Medicine[edit] Traditional medical uses of coca are foremost as a stimulant to overcome fatigue, hunger, and thirst. It is considered particularly effective against altitude sickness.[33] It also is used as an anesthetic and analgesic to alleviate the pain of headache, rheumatism, wounds and sores, etc. Before stronger anaesthetics were available, it also was used for broken bones, childbirth, and during trepanning operations on the skull.[33] The high calcium content in coca explains why people used it for bone fractures.[33] Because coca constricts blood vessels, it also serves to oppose bleeding, and coca seeds were used for nosebleeds. Indigenous use of coca has also been reported as a treatment for malaria, ulcers, asthma, to improve digestion, to guard against bowel laxity, as an aphrodisiac, and credited with improving longevity. Modern studies have supported a number of these medical applications.[18][33] Nutrition[edit] Raw coca leaves, chewed or consumed as tea or mate de coca, are rich in nutritional properties. Specifically, the coca plant contains essential minerals (calcium, potassium, phosphorus), vitamins (B1, B2, C, and E) and nutrients such as protein and fiber.[34][35] Religion[edit] Coca
Coca
has also been a vital part of the religious cosmology of the Andean peoples of Peru, Bolivia, Ecuador, Colombia, northern Argentina, and Chile from the pre- Inca
Inca
period through to the present. Coca
Coca
leaves play a crucial part in offerings to the apus (mountains), Inti
Inti
(the sun), or Pachamama
Pachamama
(the earth). Coca
Coca
leaves are also often read in a form of divination analogous to reading tea leaves in other cultures. As one example of the many traditional beliefs about coca, it is believed by the miners of Cerro de Pasco
Cerro de Pasco
to soften the veins of ore, if masticated (chewed) and thrown upon them (see Cocomama in Inca mythology).[citation needed] In addition, coca use in shamanic rituals is well documented wherever local native populations have cultivated the plant. For example, the Tayronas of Colombia's Sierra Nevada de Santa Marta would chew the plant before engaging in extended meditation and prayer.[36] Traditional preparation[edit] Traditionally, coca leaves are prepared either to chew[37] or as a tea[38] (mate de coca). Chew[edit]

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In Bolivia
Bolivia
bags of coca leaves are sold in local markets and by street vendors. The activity of chewing coca is called mambear, chacchar or acullicar, borrowed from Quechua, coquear (northern Argentina), or in Bolivia, picchar, derived from the Aymara language. The Spanish masticar is also frequently used, along with the slang term "bolear," derived from the word "bola" or ball of coca pouched in the cheek while chewing. Typical coca consumption is about 2 ounces (57 grams) per day,[citation needed] and contemporary methods are believed to be unchanged from ancient times.[citation needed] Coca
Coca
is kept in a woven pouch (chuspa or huallqui). A few leaves are chosen to form a quid (acullico) held between the mouth and gums. Doing so may cause a tingling and numbing sensation in their mouths. (The formerly ubiquitous dental anaesthetic novocaine / procaine has a similar effect.) Chewing coca leaves is most common in indigenous communities across the central Andean region,[36] particularly in places like the highlands of Argentina, Colombia, Bolivia
Bolivia
and Peru, where the cultivation and consumption of coca is as much a part of the national culture, similar to chicha. It also serves as a powerful symbol of indigenous cultural and religious identity, amongst a diversity of indigenous nations throughout South America.[36] Tobacco
Tobacco
leaves were also traditionally chewed in the same way in North America, though modern chewing tobacco is typically heavily processed.

llipta is used to improve extraction when chewing coca (Museo de la Coca, Cusco, Peru)

One option for chewing coca is with a tiny quantity of ilucta (a preparation of the ashes of the quinoa plant) added to the coca leaves; it softens their astringent flavor and activates the alkaloids.[citation needed] Other names for this basifying substance are llipta in Peru
Peru
and the Spanish word lejía, bleach in English. The consumer carefully uses a wooden stick (formerly often a spatula of precious metal) to transfer an alkaline component into the quid without touching his flesh with the corrosive substance. The alkali component, usually kept in a gourd (ishcupuro or poporo), can be made by burning limestone to form unslaked quicklime, burning quinoa stalks, or the bark from certain trees, and may be called ilipta, tocra or mambe depending on its composition.[29][30] Many of these materials are salty in flavor, but there are variations. The most common base[citation needed] in the La Paz
La Paz
area of Bolivia
Bolivia
is a product known as lejía dulce (sweet lye), which is made from quinoa ashes mixed with aniseed and cane sugar, forming a soft black putty with a sweet and pleasing flavor. In some places, baking soda is used under the name bico. In the Sierra Nevada de Santa Marta, on the Caribbean Coast of Colombia, coca is consumed[36] by the Kogi, Arhuaco
Arhuaco
and Wiwa by using a special device called poporo.[36] It represents the womb and the stick is a phallic symbol. The movements of the stick in the poporo symbolize the sexual act. For a man the poporo is a good companion that means "food", "woman", "memory", and "meditation". The poporo is the mark of manhood. When a boy is ready to be married, his mother initiates him in the use of the coca. This act of initiation is carefully supervised by the Mamo, a traditional priest-teacher-leader.[citation needed] Fresh samples of the dried leaves, uncurled, are a deep green colour on the upper, and a grey-green on the lower surface, and have a strong tea-like aroma. When chewed, they produce a pleasurable numbness in the mouth, and have a pleasant, pungent taste. They are traditionally chewed with lime or some other reagent such as bicarbonate of soda to increase the release of the active ingredients from the leaf. Older species have a camphoraceous smell and a brownish color, and lack the pungent taste. Tea[edit]

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A cup of mate de coca served in a coffee shop in Cuzco, Peru.

Main article: Coca
Coca
tea Although coca leaf chewing is common only among the indigenous populations,[33] the consumption of coca tea (Mate de coca) is common among all sectors of society in the Andean countries, especially due to their high elevations from sea level,[33] and is widely held to be beneficial to health, mood, and energy.[33] Coca leaf
Coca leaf
is sold packaged into teabags in most grocery stores in the region, and establishments that cater to tourists generally feature coca tea. Commercial and industrial uses[edit] In the Andes
Andes
commercially manufactured coca teas, granola bars, cookies, hard candies, etc. are available in most stores and supermarkets, including upscale suburban supermarkets.[citation needed] Coca
Coca
is used industrially in the cosmetics and food industries. A decocainized extract of coca leaf is one of the flavoring ingredients in Coca-Cola. Before the criminalization of cocaine, however, the extract was not decocainized. Therefore, Coca-Cola's original formula did include cocaine.[5][39][40] Coca tea
Coca tea
is produced industrially from coca leaves in South America by a number of companies, including Enaco S.A. (National Company of the Coca) a government enterprise in Peru.[41][42] Coca
Coca
leaves are also found in a brand of herbal liqueur called "Agwa de Bolivia" (grown in Bolivia
Bolivia
and de-cocainized in Amsterdam),[43] and a natural flavouring ingredient in Red Bull Cola, that was launched in March 2008.[44] New markets[edit] Beginning in the early 21st century, there has been a movement in Bolivia, Peru,[45] and Venezuela to promote and expand legal markets for the crop. The presidents of these three countries have personally identified with this movement. In particular, Evo Morales
Evo Morales
of Bolivia (elected in December 2005) was a coca grower's union leader. Morales asserts that "la coca no es cocaína"—the coca leaf is not cocaine. During his speech to the General Assembly of the United Nations
General Assembly of the United Nations
on September 19, 2006, he held a coca leaf in his hand to demonstrate its innocuity.[46] Alan García, president of Peru, has recommended its use in salads and other edible preparations. A Peruvian-based company has announced plans to market a modern version of Vin Mariani, which will be available in both natural and de-cocainized varieties. In Venezuela, former president Hugo Chávez
Hugo Chávez
said in a speech on January 2008 that he chews coca every day, and that his "hook up" is Bolivian president Evo Morales. Chávez reportedly said "I chew coca every day in the morning... and look how I am" before showing his biceps to his audience, the Venezuelan National Assembly.[citation needed] On the other hand, the Colombian government has recently moved in the opposite direction. For years, Bogotá
Bogotá
has allowed indigenous coca farmers to sell coca products, promoting the enterprise as one of the few successful commercial opportunities available to recognized tribes like the Nasa, who have grown it for years and regard it as sacred.[47] In December 2005, the Paeces – a Tierradentro (Cauca) indigenous community – started to produce a carbonated soft drink called " Coca
Coca
Sek". The production method belongs to the resguardos of Calderas (Inzá) and takes about 150 kg (331 lb) of coca per 3,000 produced bottles. The drink was never sold widely in Colombia and efforts to do so ended in May 2007 when it was abruptly banned by the Colombian government.[citation needed] Coca Colla is an energy drink which is produced in Bolivia
Bolivia
with the use of coca extract as its base. It was launched on the Bolivian market in La Paz, Santa Cruz and Cochabamba
Cochabamba
in mid-April 2010.[48][49] Literary references[edit] Probably the earliest reference to coca in English literature is Abraham Cowley's poem "A Legend of Coca"[50] in his 1662 collection of poems "Six Books of Plants". International prohibition of coca leaf[edit] Coca leaf
Coca leaf
is the raw material for the manufacture of the drug cocaine, a powerful stimulant and anaesthetic extracted chemically from large quantities of coca leaves. Today, since it has mostly been replaced as a medical anaesthetic by synthetic analogues such as procaine, cocaine is best known as an illegal recreational drug. The cultivation, sale, and possession of unprocessed coca leaf (but not of any processed form of cocaine) is generally legal in the countries – such as Bolivia, Peru, Chile and Argentina
Argentina
– where traditional use is established, although cultivation is often restricted in an attempt to control the production of cocaine. In the case of Argentina, it is legal only in some northern provinces where the practice is so common that the state has accepted it. The prohibition of the use of the coca leaf except for medical or scientific purposes was established by the United Nations in the 1961 Single Convention on Narcotic Drugs. The coca leaf is listed on Schedule I of the 1961 Single Convention together with cocaine and heroin. The Convention determined that "The Parties shall so far as possible enforce the uprooting of all coca bushes which grow wild. They shall destroy the coca bushes if illegally cultivated" (Article 26), and that, " Coca leaf
Coca leaf
chewing must be abolished within twenty-five years from the coming into force of this Convention" (Article 49, 2.e).[51] The historic rationale for international prohibition of coca leaf in the 1961 Single Convention comes from "The Commission of Enquiry on the Coca
Coca
Leaf
Leaf
study" published in 1950. It was requested of the United Nations by the permanent representative of Peru, and was prepared by a commission that visited Bolivia
Bolivia
and Peru
Peru
briefly in 1949 to "investigate the effects of chewing the coca leaf and the possibilities of limiting its production and controlling its distribution." It concluded that the effects of chewing coca leaves were negative, even though chewing coca was defined as a habit, not an addiction.[52][53] The report was sharply criticised for its arbitrariness, lack of precision and racist connotations.[33] The team members' professional qualifications and parallel interests were also criticised, as were the methodology used and the incomplete selection and use of existing scientific literature on the coca leaf. Questions have been raised as to whether a similar study today would pass the scrutiny and critical review to which scientific studies are routinely subjected.[40] Despite the legal restriction among countries party to the international treaty, coca chewing and drinking of coca tea is carried out daily by millions of people in the Andes
Andes
as well as considered sacred within indigenous cultures. Coca
Coca
consumers claim that most of the information provided about the traditional use of the coca leaf and its modern adaptations are erroneous.[33] This has made it impossible to shed light on the plant's positive aspects and its potential benefits for the physical, mental and social health of the people who consume and cultivate it.[33][40] In an attempt to obtain international acceptance for the legal recognition of traditional use of coca in their respective countries, Peru
Peru
and Bolivia
Bolivia
successfully led an amendment, paragraph 2 of Article 14 into the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, stipulating that measures to eradicate illicit cultivation and to eliminate illicit demand "should take due account of traditional licit use, where there is historic evidence of such use."[54] Bolivia
Bolivia
also made a formal reservation to the 1988 Convention, which required countries to adopt measures to establish the use, consumption, possession, purchase or cultivation of the coca leaf for personal consumption as a criminal offence. Bolivia
Bolivia
stated that "the coca leaf is not, in and of itself, a narcotic drug or psychotropic substance" and stressed that its "legal system recognizes the ancestral nature of the licit use of the coca leaf, which, for much of Bolivia's population, dates back over centuries."[54][55] However, the International Narcotics Control Board (INCB) – the independent and quasi-judicial control organ for the implementation of the United Nations drug conventions – denied the validity of article 14 in the 1988 Convention over the requirements of the 1961 Convention, or any reservation made by parties, since it does not "absolve a party of its rights and obligations under the other international drug control treaties."[56] The INCB stated in its 1994 Annual Report that "mate de coca, which is considered harmless and legal in several countries in South America, is an illegal activity under the provisions of both the 1961 Convention and the 1988 Convention, though that was not the intention of the plenipotentiary conferences that adopted those conventions."[57] It implicitly also dismissed the original report of the Commission of Enquiry on the Coca
Coca
Leaf
Leaf
by recognizing that "there is a need to undertake a scientific review to assess the coca-chewing habit and the drinking of coca tea."[58] Nevertheless, the INCB on other occasions did not show signs of an increased sensitivity towards the Bolivian claim on the rights of their indigenous population, and the general public, to consume the coca leaf in a traditional manner by chewing the leaf, and drinking coca tea, as "not in line with the provisions of the 1961 Convention."[59][60] The Board considered Bolivia, Peru
Peru
and a few other countries that allow such practises to be in breach with their treaty obligations, and insisted that "each party to the Convention should establish as a criminal offence, when committed intentionally, the possession and purchase of coca leaf for personal consumption."[61] In reaction to the 2007 Annual Report of the INCB, the Bolivian government announced that it would formally issue a request to the United Nations to unschedule the coca leaf of List 1 of the 1961 UN Single Convention.[62] Bolivia
Bolivia
led a diplomatic effort to do so beginning in March 2009, but eighteen countries out of a total of 184, those 18 being listed as followed (chronologically: the United States, Sweden, United Kingdom, Latvia, Japan, Canada, France, Germany, Bulgaria, Slovakia, Denmark, Estonia, Italy, Mexico, Russian Federation, Malaysia, Singapore, and Ukraine) objected to the change before the January 2011 deadline. A single objection would have been sufficient to block the modification. The legally unnecessary step of supporting the change was taken formally by Spain, Ecuador, Venezuela, and Costa Rica.[63] In June 2011, Bolivia
Bolivia
moved to denounce the 1961 Convention over the prohibition of the coca leaf.[64] Since the 1980s, the countries in which coca is grown have come under political and economic pressure from the United States to restrict the cultivation of the crop in order to reduce the supply of cocaine on the international market.[33] Article 26 of the Single Convention on Narcotic Drugs
Single Convention on Narcotic Drugs
requires nations that allow the cultivation of coca to designate an agency to regulate said cultivation and take physical possession of the crops as soon as possible after harvest, and to destroy all coca which grows wild or is illegally cultivated. The effort to enforce these provisions, referred to as coca eradication, has involved many strategies, ranging from aerial spraying of herbicides on coca crops to assistance and incentives to encourage farmers to grow alternative crops.[37] This effort has been politically controversial,[65] with proponents claiming[citation needed] that the production of cocaine is several times the amount needed to satisfy legal demand and inferring that the vast majority of the coca crop is destined for the illegal market. As per the proclaimed view, this would not only contributes to the major social problem of drug abuse but also financially supports insurgent groups that collaborate with drug traffickers in some cocaine-producing territories. Critics of the effort claim[33] that it creates hardship primarily for the coca growers, many of whom are poor and have no viable alternative way to make a living, causes environmental problems, that it is not effective in reducing the supply of cocaine, in part because cultivation can move to other areas, and that any social harm created by drug abuse is only made worse by the War on Drugs.[33] The environmental problems include "ecocide", where vast tracts of land and forest are sprayed with glyphosate or Roundup, with the intention of eradicating the coca plant.[33] However, the incidental environmental damage is severe, because many plant species are wiped out in the process.[33] Coca
Coca
has been reintroduced to the United States as a flavoring agent in the herbal liqueur Agwa de Bolivia.[citation needed] Boliviana negra, a genetically engineered type of coca, resists glyphosate herbicides and increases yields. Legal status[edit] See also: Coca
Coca
in Bolivia The primary organization authorized to purchase coca leaves is ENACO S.A., headquartered in Peru.[66] Outside of South America, most countries' laws make no distinction between the coca leaf and any other substance containing cocaine, so the possession of coca leaf is prohibited. In South America coca leaf is illegal in both Paraguay and Brazil. Netherlands[edit] In the Netherlands, coca leaf is legally in the same category as cocaine, both are List I drugs of the Opium
Opium
Law. The Opium
Opium
Law specifically mentions the leaves of the plants of the genus Erythroxylon. However, the possession of living plants of the genus Erythroxylon is not actively prosecuted, even though they are legally forbidden. United States[edit] In the United States, a Stepan Company plant in Maywood, New Jersey
Maywood, New Jersey
is a registered importer of coca leaf. The company manufactures pure cocaine for medical use and also produces a cocaine-free extract of the coca leaf, which is used as a flavoring ingredient in Coca-Cola. Other companies have registrations with the DEA to import coca leaf according to 2011 Federal Register Notices for Importers,[67] including Johnson Matthey, Inc, Pharmaceutical Materials; Mallinckrodt Inc; Penick Corporation; and the Research Triangle Institute. Analysts have noted the substantial importation of coca leaf into the USA.,[68] but the actual quantity is unknown. Canada[edit] Coca leaf
Coca leaf
is listed as a Schedule I drug (most dangerous) according to the Controlled Drugs and Substances Act of Canada (S.C. 1996, c. 19) alongside Opium
Opium
(Heroin) and synthetic opioid analgesics. Specifically, it lists Coca
Coca
(Erythroxylon), its preparations, derivatives, alkaloids and salts, including:(1) Coca
Coca
leaves (2) Cocaine
Cocaine
and (3) Ecgonine. Possession of a Schedule I substance is illegal and trafficking can result in punishment up to life imprisonment.[69] Australia[edit] Coca leaf
Coca leaf
is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).[70] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[70] See also[edit]

Alcohol and Drugs History Society Illegal drug trade in Latin America

References[edit]

^ Drug Enforcement Administration
Drug Enforcement Administration
(April 23, 2013). "Coca: History". archive.org/. Internet Archive. Archived from the original on October 25, 2014. Retrieved February 16, 2015.  ^ a b Plowman, T (1979). "Botanical Perspectives on Coca". Journal of Psychedelic Drugs. 11 (1–2): 103–117.  ^ De la Cruz, Manuel. "Policía mexicana realiza el primer hallazgo de cultivos de coca en el sur del país". La Republica. Retrieved 27 March 2016.  ^ Plowman, T; Rivier L (1983). " Cocaine
Cocaine
and Cinnamoylcocaine content of thirty-one species of Erythroxylum (Erythroxylaceae)". Annals of Botany. London. 51: 641–659.  ^ a b May, Clifford D (1988-07-01). "How Coca-Cola
Coca-Cola
Obtains Its Coca". The New York Times. A Stepan laboratory in Maywood, N.J., is the nation's only legal commercial importer of coca leaves, which it obtains mainly from Peru
Peru
and, to a lesser extent, Bolivia. Besides producing the coca flavoring agent for Coca-Cola, Stepan extracts cocaine from the coca leaves, which it sells to Mallinckrodt Inc., a St. Louis pharmaceutical manufacturer that is the only company in the United States licensed to purify the product for medicinal use.  ^ Transnational Institute – Coca
Coca
Myths ^ Plowman T. "The Origin, Evolution, and Diffusion of Coca, Erythroxylum spp., in South and Central America." In: Stone D, ed. Pre-Columbian Plant Migration. Papers of the Peabody Museum of Archaeology and Ethnology. Harvard University. Vol 76. Cambridge MA: Harvard University Press; 1984. p. 125-163. ^ Bohm, B; Ganders F; Plowman T (1982). "Biosystematics and Evolution of Cultivated Coca
Coca
(Erythroxylaceae)". Systematic Botany. 7 (2): 121–133. doi:10.2307/2418321.  ^ Johnson, E; Zhang D; Emche S (2005). "Inter- and Intra-specific Variation among Five Erythroxylum Taxa Assessed by AFLP". Annals of Botany. 95: 601–608. doi:10.1093/aob/mci062. PMC 4246853 . PMID 15650009.  ^ a b Emche, S; Zhang D; Islam M; Bailey B; Meinhardt L (2011). "AFLP Phylogeny of 36 Erythroxylum Species Genetic Relationships Among Erythroxylum Species Inferred by AFLP Analysis". Tropical Plant Biology. 4: 126–133. doi:10.1007/s12042-011-9070-9.  ^ Islam M. Tracing the Evolutionary History of Coca
Coca
(Erythroxylum) [PhD thesis]. Boulder: University of Colorado, Boulder; 2011 ^ Evolutionary History: Uniting History and Biology to Understand Life on Earth, Edmund Russell. Cambridge University Press. 2011. ISBN 978-0-521-74509-3. Retrieved 2011-03-12.  ^ Davis, Joshua (2004), "The Mystery of the Coca
Coca
Plant That Wouldn't Die", WIRED, 12 (11)  ^ Dion, Michelle L; Russler, Catherine (2008). "Eradication Efforts, The State, Displacement And Poverty: Explaining Coca
Coca
Cultivation In Colombia
Colombia
During Plan Colombia". Journal of Latin American Studies. 40.3: 399–421. doi:10.1017/s0022216x08004380.  ^ The discovery of Mexico's first coca plantation Vice ^ "Illicit Production of Cocaine
Cocaine
– [www.rhodium.ws]". Erowid.org. Retrieved 2013-03-26.  ^ Jenkins, Amanda; Llosa, Teobaldo; Montoya, Ivan; Cone, Edward (February 9, 1996). "Identification and quantitation of alkaloids in coca tea". Forensic Sci Int. 77 (3): 179–189. doi:10.1016/0379-0738(95)01860-3. PMC 2705900 . PMID 8819993.  ^ a b Weil, AT (Mar–May 1981). "The therapeutic value of coca in contemporary medicine". Journal of Ethnopharmacology. 3 (2–3): 367–76. doi:10.1016/0378-8741(81)90064-7. PMID 6113306.  ^ National Institute on Drug Abuse. "Letter from the Director – National Institute on Drug Abuse (NIDA)". nih.gov.  ^ BS, Liao; RL, Hilsinger; BM, Rasgon; K, Matsuoka; KK, Adour (Jan 1999). "A preliminary study of cocaine absorption from the nasal mucosa". Laryngoscope. 109 (1): 98–102. doi:10.1097/00005537-199901000-00019. PMID 9917048.  ^ Mazor, Susan; Mycyk, Mark; Wills, Brandon; Brace, Larry; Gussow, Leon; Erickson, Timothy (Dec 2006). " Coca tea
Coca tea
consumption causes positive urine cocaine assay" (PDF). Eur J Emerg Med. 13 (6): 341. Retrieved August 4, 2014.  ^ Jackson, GF; Saady, JJ; Poklis, A (Jan–Feb 1991). "Urinary excretion of benzoylecgonine following ingestion of Health Inca
Inca
Tea". Forensic Sci Int. 49 (1): 57–64. doi:10.1016/0379-0738(91)90171-e. PMID 2032667.  ^ Hanna JM, Hornick CA., "Use of coca leaf in southern Peru: adaptation or addiction," Bull Narc. 1977 Jan–Mar;29(1):63–74. ^ "Report of the Commission of Enquiry on the Coca
Coca
Leaf" (PDF). United Nations Economic and Social Council: 31. May 1950. Retrieved August 4, 2014.  ^ Hurtado-Gumucio, J (October 2000). " Coca leaf
Coca leaf
chewing as therapy for cocaine maintenance". Ann Med Interne. 151 Suppl B: B44–8. PMID 11104945.  ^ Oswaldo Francisco Ribas Lobos Fernández, doctoral thesis, Federal University of Bahia (UFBA), 2007; " Coca
Coca
Light?" ^ Rivera MA; Aufderheide AC; Cartmell LW; Torres CM; Langsjoen O (December 2005). "Antiquity of coca-leaf chewing in the south central Andes: a 3,000 year archaeological record of coca-leaf chewing from northern Chile". Journal of Psychoactive Drugs. 37 (4): 455–458. doi:10.1080/02791072.2005.10399820.  ^ Dillehay; et al. (2010). "Early Holocene coca chewing in northern Peru". Antiquity. 84 (326): 939–953.  ^ a b Robert C. Peterson, Ph.D. (May 1977). "NIDA research monograph #13: Cocaine
Cocaine
1977, Chapter I" (PDF). Retrieved 2007-05-26.  ^ a b Eleanor Carroll, M.A. "Coca: the plant and its use" (PDF). Retrieved 2007-05-26.  ^ Inciardi, James A. (1992). The War on Drugs
War on Drugs
II. Mayfield Publishing Company. p. 6. ISBN 1-55934-016-9.  ^ a b Musto, DF (1998). "International traffic in coca through the early 20th century". Drug and Alcohol Dependence. 49 (2): 145–156. doi:10.1016/s0376-8716(97)00157-9.  ^ a b c d e f g h i j k l m n o Transnational Institute – Coca Myths, 2009 ^ James, A., Aulick, D., Plowman, T., 1975 "Nutritional Value of Coca", Botanical Museum Leaflets, Harvard University 24 (6): 113–119. ^ Harvard Study – Nutritional Value of Coca
Coca
Leaf
Leaf
(Duke, Aulick, Plowman 1975) ^ a b c d e Museo del Oro, Banco de la Republica. "Museo del Oro, Colombia" (in Spanish). Banrep.gov.co. Archived from the original on 2013-05-11. Retrieved 2012-11-09.  ^ a b Transnational Institute – Coca
Coca
Myths, 2009. ^ "Drugs and Democracy Coca
Coca
leaf: Myths and Reality". Tni.org. 2011-02-18. Retrieved 2012-11-09.  ^ Benson, Drew. " Coca
Coca
kick in drinks spurs export fears Archived 2012-05-30 at Archive.is", The Washington Times, April 20, 2004. "Coke dropped cocaine from its recipe around 1900, but the secret formula still calls for a cocaine-free coca extract produced at a Stepan Co. factory in Maywood, N.J. Stepan buys about 100 metric tons of dried Peruvian coca leaves each year, said Marco Castillo, spokesman for Peru's state-owned National Coca
Coca
Co." ^ a b c Coca
Coca
Yes, Cocaine
Cocaine
No? Legal Options for the Coca
Coca
Leaf, Transnational Institute, Drugs & Conflict Debate Paper 13, May 2006 ^ (in Spanish) Empresa Nacional de la Coca
Coca
S.A ^ Peruvian Drug Control Agency: Coca
Coca
Cola Buys Coca
Coca
Leaves, The Narco News Bulletin, January 28, 2005 ^ Agwabuzz.com Agwa de Bolivia
Bolivia
herbal liqueur official site ^ The Cola from Red Bull Archived June 3, 2013, at the Wayback Machine. ^ Dean, Bartholomew 2013" Cocaine
Cocaine
Capitalisms & Social Trauma in Peruvian Amazonia", Panoramas, University of Pittsburgh (July 17) [1] ^ Statement of Evo Morales
Evo Morales
Aima, President of Bolivia
Bolivia
at the 61st session of the United Nations General Assembly, September 19, 2006 ^ Bolivia
Bolivia
and Peru
Peru
Defend Coca
Coca
Use March 6, 2008. "The United Nations lacks respect for the indigenous people of Peru
Peru
and Bolivia
Bolivia
who have used the coca leaf since forever," said Peruvian Congresswoman Maria Sumire. "For indigenous people, coca is a sacred leaf that is part of their cultural identity," she said. ^ " Evo Morales
Evo Morales
launches ' Coca
Coca
Colla'". Telegraph. 10 January 2010. Retrieved 22 January 2010.  ^ " Bolivia
Bolivia
banks on ' Coca
Coca
Colla,' fizzy coca-leaf drink". AFP. 10 January 2010. Retrieved 22 January 2010.  ^ Peru. History of coca, "the divine plant" of the Incas; with an introductory account of the Incas, and of the Andean Indians of to-day. W. Golden Mortimer, M.D. Ed. J. H. Vail & Co, 1901. Abraham Cowley's poem "A Legend of Coca" : in chapter I An introduction to the history of coca, pp. 25–27. ^ Single Convention on Narcotic Drugs
Single Convention on Narcotic Drugs
Archived 2008-05-09 at the Wayback Machine. ^ Commission of Enquiry on the Coca
Coca
Leaf, UNGASS 10-year review website, Transnational Institute ^ The Commission of Enquiry on the Coca
Coca
Leaf, Bulletin on Narcotics – 1949 Issue 1 ^ a b The resolution of ambiguities regarding coca, Transnational Institute, March 2008 ^ Status of treaty adherence, United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances ^ Report of the International Narcotics Control Board for 2007 Archived 2008-09-10 at the Wayback Machine., paragraph 220 ^ Evaluation of the effectiveness of the international drug control treaties, Supplement to the INCB Annual Report for 1994 (Part 3) ^ Evaluation of the effectiveness of the international drug control treaties, Supplement to the INCB Annual Report for 1994 (Part 1) ^ Report of the International Narcotics Control Board for 2007 Archived 2008-09-10 at the Wayback Machine., paragraph 217 ^ Response to the 2007 Annual Report of the International Narcotics Control Board, International Drug Policy Consortium (IDPC), March 2008 ^ Report of the International Narcotics Control Board for 2007 Archived 2008-09-10 at the Wayback Machine., paragraph 219 ^ Letter Evo Morales
Evo Morales
to UN Secretary General Ban Ki-moon, March 8, 2008 ^ "Objections and support for Bolivia's coca amendment". Transnational Institute.  ^ "Aprueban denuncia contra la Convención de Viena". Los Tiempos. 2011-06-23. Retrieved 2011-06-23.  ^ Failed States and failed policies: how to stop the drug wars. The Economist, May 2009 ^ http://www.csdp.org/research/12_coca_drugs_and_social_protest_in_bolivia_and_peru.pdf ^ "Importers Notice of Registration – 2011". deaDiversion.usdoj.gov. Retrieved 2012-11-09.  ^ https://www.youtube.com/watch?v=Owl59XeknxU ^ http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-2.html#docCont ^ a b Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534

Turner C. E., Elsohly M. A., Hanuš L., Elsohly H. N. Isolation of dihydrocuscohygrine from Peruvian coca leaves. Phytochemistry 20 (6), 1403–1405 (1981) History of Coca. The Divine Plant of the Incas by W. Golden Mortimer, M.D. 576 pp. And/Or Press San Francisco, 1974. This title has no ISBN. [A] http://tairona.myzen.co.uk/index.php/culture/the_use_of_coca_in_south_america

 Chisholm, Hugh, ed. (1911). "Coca". Encyclopædia Britannica. 6 (11th ed.). Cambridge University Press. pp. 614–615.  External links[edit]

Wikimedia Commons has media related to Erythroxylum coca.

Wikispecies
Wikispecies
has information related to Erythroxylum coca

Wikivoyage has a travel guide for Coca.

Shared Responsibility Coca
Coca
leaf: Myths and Reality Transnational Institute (TNI) Unscheduling the coca leaf, Transnational Institute (TNI) Coca leaf
Coca leaf
news page

v t e

Ancient anaesthesia

Plants / animals

Aconitum
Aconitum
(aconite) Atropa belladonna
Atropa belladonna
(belladonna) Cannabis

medical use

Castoreum Coca Conium
Conium
(hemlock) Datura innoxia
Datura innoxia
(thorn-apple) Datura metel
Datura metel
(devil's trumpet) Hyoscyamus niger
Hyoscyamus niger
(henbane) Lactucarium Mandragora officinarum
Mandragora officinarum
(mandrake) Opium Saussurea
Saussurea
(saw-wort) Willow

People

Abulcasis Avenzoar Avicenna Celsus Dioscorides Galen Hippocrates Rhazes Sabuncuoğlu Sushrutha Theophrastus Zhang

Compounds

Aconitine Atropine Cocaine Coniine Hyoscine Δ9-THC Hyoscyamine Morphine Salicylate

v t e

Stimulants

Adamantanes

Adapromine Amantadine Bromantane Memantine Rimantadine

Adenosine antagonists

8-Chlorotheophylline 8-Cyclopentyltheophylline 8-Phenyltheophylline Aminophylline Caffeine CGS-15943 Dimethazan Paraxanthine SCH-58261 Theobromine Theophylline

Alkylamines

Cyclopentamine Cypenamine Cyprodenate Heptaminol Isometheptene Levopropylhexedrine Methylhexaneamine Octodrine Propylhexedrine Tuaminoheptane

Ampakines

CX-516 CX-546 CX-614 CX-691 CX-717 IDRA-21 LY-404,187 LY-503,430 Nooglutyl Org 26576 PEPA S-18986 Sunifiram Unifiram

Arylcyclohexylamines

Benocyclidine Dieticyclidine Esketamine Eticyclidine Gacyclidine Ketamine Phencyclamine Phencyclidine Rolicyclidine Tenocyclidine Tiletamine

Benzazepines

6-Br-APB SKF-77434 SKF-81297 SKF-82958

Cholinergics

A-84,543 A-366,833 ABT-202 ABT-418 AR-R17779 Altinicline Anabasine Arecoline Bradanicline Cotinine Cytisine Dianicline Epibatidine Epiboxidine GTS-21 Ispronicline Nicotine PHA-543,613 PNU-120,596 PNU-282,987 Pozanicline Rivanicline Sazetidine A SIB-1553A SSR-180,711 TC-1698 TC-1827 TC-2216 Tebanicline UB-165 Varenicline WAY-317,538

Convulsants

Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone

Eugeroics

Adrafinil Armodafinil CRL-40,940 CRL-40,941 Fluorenol JZ-IV-10 Modafinil

Oxazolines

4-Methylaminorex Aminorex Clominorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone

Phenethylamines

1-(4-Methylphenyl)-2-aminobutane 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane 2-Fuoroamphetamine 2-Fuoromethamphetamine 2-OH-PEA 2-Phenyl-3-aminobutane 2,3-MDA 3-Fuoroamphetamine 3-Fluoroethamphetamine 3-Fluoromethcathinone 3-Methoxyamphetamine 3-Methylamphetamine 3,4-DMMC 4-BMC 4-CMC 4-Ethylamphetamine 4-Fluoroamphetamine 4-Fluoromethamphetamine 4-MA 4-Methylbuphedrone 4-Methylcathinone 4-MMA 4-Methylpentedrone 4-MTA 6-FNE AL-1095 Alfetamine a-Ethylphenethylamine Amfecloral Amfepentorex Amfepramone Amidephrine 2-Amino-1,2-dihydronaphthalene 2-Aminoindane 5-(2-Aminopropyl)indole 2-Aminotetralin Acridorex Amphetamine
Amphetamine
(Dextroamphetamine, Levoamphetamine) Amphetaminil Arbutamine β-Methylphenethylamine β-Phenylmethamphetamine Benfluorex Benzedrone Benzphetamine BDB BOH 3-Benzhydrylmorpholine BPAP Buphedrone Bupropion Butylone Camfetamine Cathine Cathinone Chlorphentermine Cilobamine Cinnamedrine Clenbuterol Clobenzorex Cloforex Clortermine Cypenamine D-Deprenyl Denopamine Dimethoxyamphetamine Dimethylamphetamine Dimethylcathinone Dobutamine DOPA (Dextrodopa, Levodopa) Dopamine Dopexamine Droxidopa EBDB Ephedrine Epinephrine Epinine Etafedrine Ethcathinone Ethylnorepinephrine Ethylone Etilamfetamine Etilefrine Famprofazone Fencamfamin Fencamine Fenethylline Fenfluramine
Fenfluramine
(Dexfenfluramine, Levofenfluramine) Fenproporex Feprosidnine Flephedrone Fludorex Formetorex Furfenorex Gepefrine Hexapradol Hexedrone HMMA Hordenine 4-Hydroxyamphetamine 5-Iodo-2-aminoindane Ibopamine IMP Indanylamphetamine Iofetamine Isoetarine Isoethcathinone Isoprenaline L-Deprenyl (Selegiline) Lefetamine Lisdexamfetamine Lophophine MBDB MDA (tenamfetamine) MDBU MDEA MDMA
MDMA
(midomafetamine) MDMPEA MDOH MDPR MDPEA Mefenorex Mephedrone Mephentermine Metanephrine Metaraminol Mesocarb Methamphetamine
Methamphetamine
(Dextromethamphetamine, Levomethamphetamine) Methoxamine Methoxyphenamine MMA Methcathinone Methedrone Methoxyphenamine Methylenedioxycathinone Methylone Mexedrone MMDA MMDMA MMMA Morforex N,alpha-Diethylphenylethylamine N-Ethylbuphedrone N-Ethylhexedrone N,N-Dimethylphenethylamine Naphthylamphetamine Nisoxetine Norepinephrine Norfenefrine Norfenfluramine Normetanephrine L-Norpseudoephedrine Octopamine (drug) Orciprenaline Ortetamine Oxifentorex Oxilofrine PBA PCA PCMA PHA Pentorex Pentedrone Pentylone Phenatine Phenpromethamine Phentermine Phenylalanine Phenylephrine Phenylpropanolamine Pholedrine PIA PMA PMEA PMMA PPAP Phthalimidopropiophenone Prenylamine Propylamphetamine Pseudoephedrine Ropinirole Salbutamol
Salbutamol
(Levosalbutamol) Sibutramine Solriamfetol Synephrine Theodrenaline Tiflorex Tranylcypromine Tyramine Tyrosine Xylopropamine Zylofuramine

Phenylmorpholines

3-Fluorophenmetrazine Fenbutrazate Fenmetramide G-130 Manifaxine Morazone Morforex Oxaflozane PD-128,907 Phendimetrazine Phenmetrazine 2-Phenyl-3,6-dimethylmorpholine Pseudophenmetrazine Radafaxine

Piperazines

2C-B-BZP 3C-PEP BZP CM156 DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 GBR-13119 MeOPP MBZP oMPP Vanoxerine

Piperidines

1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine 2-Benzylpiperidine 2-Methyl-3-phenylpiperidine 3,4-Dichloromethylphenidate 4-Benzylpiperidine 4-Fluoromethylphenidate 4-Methylmethylphenidate Desoxypipradrol Difemetorex Diphenylpyraline Ethylnaphthidate Ethylphenidate Methylnaphthidate Isopropylphenidate Methylphenidate
Methylphenidate
(Dexmethylphenidate) Nocaine Phacetoperane Pipradrol Propylphenidate SCH-5472

Pyrrolidines

2-Diphenylmethylpyrrolidine 5-DBFPV α-PPP α-PBP α-PHP α-PVP α-PVT Diphenylprolinol DMPVP FPOP FPVP MDPPP MDPBP MPBP MPHP MPPP MOPVP MOPPP Indapyrophenidone MDPV Naphyrone PEP Picilorex Prolintane Pyrovalerone

Racetams

Oxiracetam Phenylpiracetam Phenylpiracetam
Phenylpiracetam
hydrazide

Tropanes

4-fluorotropacocaine 4'-Fluorococaine Altropane
Altropane
(IACFT) Brasofensine CFT (WIN 35,428) β-CIT (RTI-55) Cocaethylene Cocaine Dichloropane
Dichloropane
(RTI-111) Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane (123I) Norcocaine PIT PTT RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-120 RTI-121
RTI-121
(IPCIT) RTI-126 RTI-150 RTI-177 RTI-229 RTI-336 RTI-354 RTI-371 RTI-386 Salicylmethylecgonine Tesofensine Troparil
Troparil
(β-CPT, WIN 35,065-2) Tropoxane WF-23 WF-33

Tryptamines

4-HO-αMT 4-Methyl-αET 4-Methyl-αMT 5-Chloro-αMT 5-Fluoro-αMT 5-MeO-αET 5-MeO-αMT 5-MeO-DIPT 6-Fluoro-αMT 7-Methyl-αET αET αMT

Others

2-MDP 3,3-Diphenylcyclobutanamine Amfonelic acid Amineptine Amiphenazole Atipamezole Atomoxetine Bemegride Benzydamine BTQ BTS 74,398 Centanafadine Ciclazindol Clofenciclan Cropropamide Crotetamide D-161 Desipramine Diclofensine Dimethocaine Efaroxan Etamivan Fenisorex Fenpentadiol Gamfexine Gilutensin GSK1360707F GYKI-52895 Hexacyclonate Idazoxan Indanorex Indatraline JNJ-7925476 Lazabemide Leptacline Lomevactone LR-5182 Mazindol Meclofenoxate Medifoxamine Mefexamide Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine Rubidium chloride Setazindol Tametraline Tandamine Thiopropamine Thiothinone Trazium UH-232 Yohimbine

.