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Ciechanover
Aaron Ciechanover ( ; he, אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist who won the Nobel Prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin. Biography Early life Ciechanover was born in Haifa, British Mandate of Palestine on 1 October 1947. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker. His mother and father supported the Zionist movement and immigrated to Israel from Poland in the 1920s. Education He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981 to 1984. Recent Ciechanover is currently a Technion Distinguished Research Professor in the Rut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or, alternatively, ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or, alternatively, ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Technion – Israel Institute Of Technology
The Technion – Israel Institute of Technology ( he, הטכניון – מכון טכנולוגי לישראל) is a public research university located in Haifa, Israel. Established in 1912 under the dominion of the Ottoman Empire, the Technion is the oldest university in the country. The Technion is ranked as one of the top universities in both Israel and the Middle East, and in the world's top 100 universities in the 2022 Academic Ranking of World Universities. The university offers degrees in science and engineering, and related fields such as architecture, medicine, industrial management, and education. It has 19 academic departments, 60 research centers, and 12 affiliated teaching hospitals. Since its founding, it has awarded more than 123,000 degrees and its graduates are cited for providing the skills and education behind the creation and protection of the State of Israel. Technion's 565 faculty members include three Nobel Laureates in chemistry. Four Nobel Laureates ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese University Of Hong Kong, Shenzhen
The Chinese University of Hong Kong, Shenzhen (CUHK-SZ) is a campus of the public Chinese University of Hong Kong in Shenzhen, Guangdong. It is a joint venture between Shenzhen University and the Chinese University of Hong Kong. CUHK-Shenzhen was officially founded on 11 October 2012 and approved by the Ministry of Education of China on 16 April 2014. Up to now, more than 4,000 undergraduate and postgraduate students are studying at The Chinese University of Hong Kong, Shenzhen. Its long-term goal is to recruit 11,000 domestic and international students, 7,500 of whom will be undergraduate students and 3,500 Masters or PhD students. Establishment Background CUHK intends to further its goals regarding education in Mainland China and conduct its further development in China with a daily-tight relationship of cooperation and combination between Hong Kong and Mainland China. Formal establishment In October 2009, CUHK started to expand its study opportunities in the Pearl River Del ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Israel Academy Of Sciences And Humanities
Israel Academy of Sciences and Humanities, based in Jerusalem, was established in 1961 by the State of Israel to foster contact between Israeli scholars in the sciences and humanities and create a think tank for advising the government on research projects of national importance. Its members include many of Israel's most distinguished scholars. The offices of the Israel Academy of Sciences and Humanities are located next door to the official residence of the President of Israel and the Council for Higher Education in Israel in Albert Einstein Square in Jerusalem. In the sciences, the Academy funds projects on the geology, flora, and fauna of Israel, and facilitates the participation of Israeli scientists in research at international projects, such as high-energy physics at CERN and synchrotron radiation at the European Synchrotron Radiation Facility. Israel has the highest concentration of scientists and engineers in the world. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Lasker Award For Basic Medical Research
The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 50% of the winners have gone on to win one. List of Albert Lasker Award for Basic Medical Research recipients {, , Valign="top", {, class="wikitable" ! Year !! Recipient , - , Rowspan="3", 2022 , , Richard O. Hynes , - , , Erkki Ruoslahti , - , , Timothy A. Springer , - , Rowspan="3", 2021 , , Karl Deisseroth , - , , Peter Hegemann , - , , Dieter Oesterhelt , - , Rowspan="1", 2020 , , not awarded , - , Rowspan="2", 2019 , , Max Dale Cooper , - , , Jacques Miller , - , Rowspan="2", 2018 , , C. David Allis , - , , Michael Grunstein , - , Rowspan="1", 2017 , , Michael N. Hall , - , Rowspan="3", 2016 , , William Kaelin, Jr. , - , , Peter J. Ratcliffe , - , , Gregg L. Semenza , - , R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ruth And Bruce Rappaport Faculty Of Medicine
The Ruth and Bruce Rappaport Faculty of Medicine is a medical school that operates in Bat Galim, Haifa and is part of the Technion's Faculty of Medicine. The faculty was established in the late 1960s by a group of physicians who found the need for an academic school specialized in medical education and research. The medical school merged with the Technion – Israel Institute of Technology in 1973. History In the late 1960s a need for a medical school and research center in Northern Israel was increasing. The medical school was established in 1969 to fill in the need. On January 3, 1971, the Technion Senate approved the merger of the Medical School with the Technion. On October 1, 1973, the school became a full faculty of the school. The academic backing and funding of the Technion progressed the expansive of the school into a full 6-year medical school. Notable achievements The faculty is the home of two Nobel Laureates The Nobel Prizes ( sv, Nobelpriset, no, Nobelprise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protalix BioTherapeutics
Protalix BioTherapeutics is an Israeli pharmaceutical company that manufactures a plant-based enzyme, taliglucerase alfa, which has received U.S. Food and Drug Administration approval for the treatment of Gaucher disease. Corporate history Protalix BioTherapeutics was established in 1993. It was founded by Yoseph Shaaltiel, who received his Ph.D. in Plant Biochemistry from the Weizmann Institute in Israel and served in the Biology Department of the Israel Defense Forces' Biological and Chemical Center. One of the earliest and largest investors in the company was Phillip Frost. Protalix has two Nobel Prize winners (Chemistry) in its Scientific Advisory Board, Roger Kornberg Ph.D and Prof. MD. Aaron Ciechanover. In its early days Protalix operated out of a warehouse in the town of Qiryat Shemona in northern Israel. On July 19, 2005, Protalix Biotherapeutics announced the closing of a $5.3 million private placement of its series C preferred stock. Protalix entered into a partne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hadassah Medical School
Hadassah Medical Center ( he, הָמֶרְכָּז הָרְפוּאִי הֲדַסָּה) is an Israeli medical organization established in 1934 that operates two university hospitals in Jerusalem – one in Ein Karem and one in Mount Scopus –, as well as schools of medicine, dentistry, nursing, and pharmacology affiliated with the Hebrew University of Jerusalem. Its declared mission is to extend a "hand to all, without regard for race, religion or ethnic origin." The hospital was founded by the Hadassah Women's Zionist Organization of America, which continues to underwrite a large part of its budget today. The Medical Center ranks as the sixth-largest hospital complex in Israel. Across its two campuses, Hadassah Medical Center has over 1,300 beds, 31 operating theaters and nine special intensive care units, and runs five schools of medical professions. History Late Ottoman period (1912–1915) The Hadassah organization was established in 1912 in New York City to provide health ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
History Of The Technion – Israel Institute Of Technology
The Technion – Israel Institute of Technology is a leading technical university in Haifa, Israel, with a history dating back to the early 20th century. Overview The extent to which technology determines history and the creation and destiny of nations is a question of historical scholarship, with the Technion – Israel Institute of Technology cited as a striking example. Initiated with the help of increasing Jewish unity made possible by the new communication technologies of the Second Industrial Revolution, the Technion was born 36 years before Israel declared independence. In that time it educated the engineers and brought the expertise to literally lay the infrastructure for a modern state. This included the fundamental infrastructure of electricity, water supplies and roads. Throughout the century – since the laying of the first cornerstone in 1912 – Technion has had a historic task in anticipating future needs in order to ensure the survival and growth of the State o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvey Lodish
Harvey Franklin Lodish (born November 16, 1941) is a molecular and cell biologist, professor at the Massachusetts Institute of Technology (MIT), Founding Member of the Whitehead Institute for Biomedical Research, and lead author of the textbook ''Molecular Cell Biology''. Lodish's research focused on cell surface proteins and other important areas at the interface between molecular cell biology and medicine. Biography Dr. Lodish received his A.B. degree Summa Cum Laude and with Highest Honors in Chemistry and Mathematics, from Kenyon College in 1962, and his Ph.D. degree in genetics with Dr. Norton Zinder from the Rockefeller University in 1966. Following two years of postdoctoral research at the M.R.C. Laboratory of Molecular Biology with Drs. Sydney Brenner and Francis Crick (winners of the Nobel Prize in Physiology or Medicine, 2002 and 1962, respectively), he joined the faculty of the MIT Department of Biology. He was promoted to Professor in 1976, and in 1983 was ap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haifa
Haifa ( he, חֵיפָה ' ; ar, حَيْفَا ') is the third-largest city in Israel—after Jerusalem and Tel Aviv—with a population of in . The city of Haifa forms part of the Haifa metropolitan area, the third-most populous metropolitan area in Israel. It is home to the Baháʼí Faith's Baháʼí World Centre, and is a UNESCO World Heritage Site and a destination for Baháʼí pilgrimage. Built on the slopes of Mount Carmel, the settlement has a history spanning more than 3,000 years. The earliest known settlement in the vicinity was Tell Abu Hawam, a small port city established in the Late Bronze Age (14th century BCE). Encyclopedia Judaica, ''Haifa'', Keter Publishing, Jerusalem, 1972, vol. 7, pp. 1134–1139 In the 3rd century CE, Haifa was known as a dye-making center. Over the millennia, the Haifa area has changed hands: being conquered and ruled by the Canaanites, Israelites, Phoenicians, Assyrians, Babylonians, Persians, Hasmoneans, Romans, Byzantines, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
