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Christopher Vakoc
Christopher Vakoc is a molecular biologist and a professor at Cold Spring Harbor Laboratory. Education Vakoc graduated with a degree in Biochemistry from Pennsylvania State University in 2001. He then attained his M.D. and his Ph.D. from the University of Pennsylvania. His PhD research was performed with Gerd Blobel on the regulation of gene expression during hematopoiesis. In 2008, he established his own independent research group at Cold Spring Harbor Laboratory. Career and research Vakoc uses CRISPR/Cas9 technology to probe the epigenetic regulation of cancer and to identify new cancer drug targets. In 2011, Vakoc discovered that the epigenetic protein BRD4 was particularly important for leukemia, leading to a series of clinical trials with a new drug, JQ1. By studying cancer epigenetics, Vakoc has also identified a new subtype of lung cancer and has discovered how gene expression changes affect metastasis in pancreatic cancer. Recently, Vakoc has developed a CRISPR scree ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetics
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene expression c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eberly College Of Science Alumni
Eberly is a surname. Notable people with the surname include: *Angelina Eberly (1798–1860) *Bob Eberly (1916–1981), American singer * Don Eberly (born 1953), American writer * George A. Eberly (1871–1958), Justice of the Nebraska Supreme Court *Janice Eberly Janice Caryl "Jan" EberlyHilary Hurd Anyaso Northwestern University News, Apr. 24, 2013. Accessed Jan. 11, 2014.Debbie RamseyFallbrook grad nominated for U.S. Dept. of Treasury post ''Fallbrook Bonsall Village News'', Aug. 11, 2011. Accessed Jan. ... (born c. 1964), American economist * Joseph H. Eberly (born 1935), American physicist * Lynn Eberly (fl. 1990s–2010s), American statistician * Robert E. Eberly (1918–2004), American chief executive See also * Eberle * Everly (other) {{surname, Eberly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biologists
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Marks Prize For Cancer Research
The Paul Marks Prize for Cancer Research is awarded by the Memorial Sloan Kettering Cancer Center to recognize cancer researchers who are making significant contributions to the understanding of cancer or are improving the treatment of the disease through basic or clinical research. The prize is awarded biennially to up to three recipients aged 45 or younger, who are selected by a panel of investigators from leading research institutions. Each presents his or her work at a scientific symposium at Memorial Sloan Kettering Cancer Center, receives a medal and shares a cash award of $150,000. The prize is named after Paul A. Marks, President Emeritus of the Memorial Sloan Kettering Cancer Center. Prizewinners SourceMemorial Sloan Kettering Cancer Center*2021 Ralph J. DeBerardinis, Sun Hur, Charles Swanton *2019 Nathanael Gray, Joshua Mendell, Christopher Vakoc *2017 Gad Getz, Chuan He, Aviv Regev *2015 Bradley Bernstein, Howard Y. Chang, and Daniel Durocher *2013 Simon J. Bou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sohn Conference Foundation
The Sohn Conference Foundation was founded in 2006 to raise money to support medical research, the development of research equipment, and programs to help children with cancer and other childhood illnesses. more than $85 million has been raised. The Sohn Conference was founded in 1995 in memory of Ira Sohn, a Wall Street professional, who died of cancer at the age of 29. At that time the conference raised money for Tomorrow's Children's Fund. The foundation has 501(c)(3) non-profit status. Conference history Launched in 1995 as the Ira Sohn Research Conference, it is now called the Sohn Investment Conference. It was created after the premature death from cancer of Ira W. Sohn, by his friends and colleagues Douglas Hirsch, Lance Laifer and Daniel Nir, together with Sohn's mother Judith Sohn and brother Evan. In May 2016, the foundation and CNBC announced a partnership to present the Sohn Investment Conferences in collaboration. The first conference presented as a partnership to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association For Cancer Research
The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including basic, clinical, and translational research into the etiology, prevention, diagnosis, and treatment of cancer. Founded in 1907 by 11 physicians and scientists, the organization now has more than 52,000 members in 130 countries and territories. The mission of the AACR is to prevent and cure cancer through research, education, communication, collaboration, science policy and advocacy, and funding for cancer research. History The AACR was founded on May 7, 1907 in Washington, DC as the "Association for Cancer Research" by a group of scientists consisting of four surgeons, five pathologists, and two biochemists. The founding members were Silas P. Beebe, George H. A. Clowes, William Coley, James Ewing, Harvey R. Gaylord, Robert B. Greenough, J. Collins War ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. In general, domains vary in length from between about 50 amino acids up to 250 amino acids in length. The shortest domains, such as zinc fingers, are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be "swapped" by genetic engineering between one protein and another to make chimeric proteins. Background The concept of the domain was first proposed in 1973 by Wetlaufer aft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR
CRISPR () (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes and provide a form of acquired immunity. CRISPR is found in approximately 50% of sequenced bacterial genomes and nearly 90% of sequenced archaea. Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and cleave specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within organisms. This editing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Scientist (magazine)
''The Scientist'' is a professional magazine intended for life scientists. Coverage includes articles on recently published research papers, current research, techniques, important career news, profiles of established and up and coming scientists, publishing, research integrity and best practices, as well as other columns and reports of interest to its readers. The editor-in-chief is Bob Grant. Overview The main purpose of the magazine is to provide print and online coverage of the latest developments in life sciences research, technology, careers, and business. Subject matter covered by the magazine includes: groundbreaking research, industry innovations, careers, financial topics, economics of science, scientific ethics, profiles of scientists, lab tools, scientific publishing, techniques, product spotlight, and guides History ''The Scientist'' was founded by Eugene Garfield in 1986. In 1988, Garfield sold ''The Scientist'', part of the ''Institute for Scientific Informat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pancreatic Cancer
Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of the body. A number of types of pancreatic cancer are known. The most common, pancreatic adenocarcinoma, accounts for about 90% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. These adenocarcinomas start within the part of the pancreas that makes digestive enzymes. Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells. About 1–2% of cases of pancreatic cancer are neuroendocrine tumors, which arise from the hormone-producing neuroendocrine cell, cells of the pancreas. These are generally less aggressive than pancreatic adenocarcinoma. Signs and symptoms of the most-common form of pancreatic cancer may include jaundice, ye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
