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Cheryll Tickle
Cheryll Anne Tickle (born 18 January 1945) is a distinguished British scientist, known for her work in developmental biology and specifically for her research into the process by which vertebrate limbs develop '' ab ovo''. She is an Emeritus Professor at the University of Bath. Education Tickle was educated at the University of Cambridge graduating with a Master of Arts degree in 1967, and received her Ph.D. from the University of Glasgow in 1970. Career and research Tickle worked as a postdoctoral researcher at Yale University, as a lecturer and reader at the Middlesex Hospital Medical School, and (after Middlesex merged with it in 1987) a reader and professor at University College London. She then moved to the University of Dundee in 1998, where she became Foulerton Professor of the Royal Society in 2000, and moved again to the University of Bath in 2007, retaining the Foulerton Professor title. Tickle's research in developmental biology investigates how single cells, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University Press
Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books by decree in 1586, it is the second oldest university press after Cambridge University Press. It is a department of the University of Oxford and is governed by a group of 15 academics known as the Delegates of the Press, who are appointed by the vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, opposite Somerville College, in the inner suburb of Jericho. For the last 500 years, OUP has primarily focused on the publication of pedagogical texts and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Master Of Arts
A Master of Arts ( la, Magister Artium or ''Artium Magister''; abbreviated MA, M.A., AM, or A.M.) is the holder of a master's degree awarded by universities in many countries. The degree is usually contrasted with that of Master of Science. Those admitted to the degree have typically studied subjects within the scope of the humanities and social sciences, such as history, literature, languages, linguistics, public administration, political science, communication studies, law or diplomacy; however, different universities have different conventions and may also offer the degree for fields typically considered within the natural sciences and mathematics. The degree can be conferred in respect of completing courses and passing examinations, research, or a combination of the two. The degree of Master of Arts traces its origins to the teaching license or of the University of Paris, designed to produce "masters" who were graduate teachers of their subjects. Europe Czech Republic a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zone Of Polarizing Activity
The zone of polarizing activity (ZPA) is an area of mesenchyme that contains signals which instruct the developing limb bud to form along the anterior/posterior axis. Limb bud is undifferentiated mesenchyme enclosed by an ectoderm covering. Eventually, the limb bud develops into bones, tendons, muscles and joints. Limb bud development relies not only on the ZPA, but also many different genes, signals, and a unique region of ectoderm called the apical ectodermal ridge (AER). Research by Saunders and Gasseling in 1948 identified the AER and its subsequent involvement in proximal distal outgrowth. Twenty years later, the same group did transplantation studies in chick limb bud and identified the ZPA. It wasn't until 1993 that Todt and Fallon showed that the AER and ZPA are dependent on each other. Patterning Patterning along the limb bud requires signals from many sources. Specifically, proteins called transcription factors (TF) help control the rate at which a gene is transcrib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apical Ectodermal Ridge
The apical ectodermal ridge (AER) is a structure that forms from the ectodermal cells at the distal end of each limb bud and acts as a major signaling center to ensure proper development of a limb. After the limb bud induces AER formation, the AER and limb mesenchyme—including the zone of polarizing activity (ZPA)—continue to communicate with each other to direct further limb development. The position of the limb bud, and hence the AER, is specified by the expression boundaries of Hox genes in the embryonic trunk. At these positions, the induction of cell outgrowth is thought to be mediated by a positive feedback loop of fibroblast growth factors (FGFs) between the intermediate mesoderm, the lateral plate mesoderm and the surface ectoderm. FGF8 in the intermediate mesoderm signals to the lateral mesoderm, restricting the expression of FGF10 through intermediate Wnt signals. Then, FGF10 in the lateral plate mesoderm signals to the surface ectoderm to create the AER, which ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewis Wolpert
Lewis Wolpert (19 October 1929 – 28 January 2021) was a South African-born British developmental biologist, author, and broadcaster. Wolpert was best known for his French flag model of embryonic development, where he used the French flag as a visual aid to explain how embryonic cells interpret genetic code for expressing characteristics of living organisms and explaining how signalling between cells early in morphogenesis could be used to inform cells with the same genetic regulatory network of their position and role. He was also an author of several science books including ''Triumph of the Embryo'' (1991), ''Malignant Sadness'' (1999), ''The Evolutionary Origins of Belief'' (2006), and ''How We Live And Why We Die: The Secret Lives of Cells'' (2009). Early life Wolpert was born on 19 October 1929, in Johannesburg to Sarah (née Suzman) and William Wolpert in a South African Jewish family of Lithuanian Jewish origin. His father was a bookshop manager and newsagent. Hi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Philip Trinkaus
John Philip "Trink" Trinkaus (23 May 1918, Rockville Centre, New York – 8 February 2003, Guilford, Connecticut) was an American embryologist and one of the world's leading experts on ''in vivo'' cell motility. Biography Trinkaus graduated in 1940 with a B.A. in biology from Wesleyan University and in 1941 with an M.A. from Columbia University. In 1941 he matriculated at Johns Hopkins University, but WW II interrupted his graduate study. In August 1942 he was drafted into the U.S. Army. In the spring of 1943 he went on leave for a week to marry Galina Gorokhoff, whom he had met a few years earlier at the Marine Biological Laboratory in Woods Hole. After being stationed in the United States and training U.S. Army Air Force officers in the use of oxygen equipment, he was sent to Italy in the autumn of 1944 to train officers in the use of G-suits. He was discharged from the U.S. Army in December 1945. In 1948 he graduated with a Ph.D. in embryology from Johns Hopkins University. In 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Sorting
Cell sorting is the process through which a particular cell type is separated from others contained in a sample on the basis of its physical or biological properties, such as size, morphological parameters, viability and both extracellular and intracellular protein expression. The homogeneous cell population obtained after sorting can be used for a variety of applications including research, diagnosis, and therapy. Methods Methods of cell sorting fall into two major categories: fluorescence activated cell sorting (FACS) and immunomagnetic cell sorting. Due to many years of refinement and increased demand for cell separation however, researchers are working to develop microfluidic sorting devices that have many benefits in comparison to the main types of fluorescence-activated cell sorting and immunomagnetic cell sorting methods. Fluorescence-activated Fluorescence-Activated Cell Sorting, is also known as flow cytometry cell sorting, or commonly known by the acronym FACS, wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryogenesis
An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm cell. The resulting fusion of these two cells produces a single-celled zygote that undergoes many cell divisions that produce cells known as blastomeres. The blastomeres are arranged as a solid ball that when reaching a certain size, called a morula, takes in fluid to create a cavity called a blastocoel. The structure is then termed a blastula, or a blastocyst in mammals. The mammalian blastocyst hatches before implantating into the endometrial lining of the womb. Once implanted the embryo will continue its development through the next stages of gastrulation, neurulation, and organogenesis. Gastrulation is the formation of the three germ layers that will form all of the different parts of the body. Neurulation forms the nervous sys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Egg Cell
The egg cell, or ovum (plural ova), is the female reproductive cell, or gamete, in most anisogamous organisms (organisms that reproduce sexually with a larger, female gamete and a smaller, male one). The term is used when the female gamete is not capable of movement (non-motile). If the male gamete (sperm) is capable of movement, the type of sexual reproduction is also classified as oogamous. A nonmotile female gamete formed in the oogonium of some algae, fungi, oomycetes, or bryophytes is an oosphere. When fertilized the oosphere becomes the oospore. When egg and sperm fuse during fertilisation, a diploid cell (the zygote) is formed, which rapidly grows into a new organism. History While the non-mammalian animal egg was obvious, the doctrine ''ex ovo omne vivum'' ("every living nimal comes froman egg"), associated with William Harvey (1578–1657), was a rejection of spontaneous generation and preformationism as well as a bold assumption that mammals also reproduced via ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fertilisation
Fertilisation or fertilization (see spelling differences), also known as generative fertilisation, syngamy and impregnation, is the fusion of gametes to give rise to a new individual organism or offspring and initiate its development. Processes such as insemination or pollination which happen before the fusion of gametes are also sometimes informally called fertilisation. The cycle of fertilisation and development of new individuals is called sexual reproduction. During double fertilisation in angiosperms the haploid male gamete combines with two haploid polar nuclei to form a triploid primary endosperm nucleus by the process of vegetative fertilisation. History In Antiquity, Aristotle conceived the formation of new individuals through fusion of male and female fluids, with form and function emerging gradually, in a mode called by him as epigenetic. In 1784, Spallanzani established the need of interaction between the female's ovum and male's sperm to form a zygote in frog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (biology)
The cell is the basic structural and functional unit of life forms. Every cell consists of a cytoplasm enclosed within a membrane, and contains many biomolecules such as proteins, DNA and RNA, as well as many small molecules of nutrients and metabolites.Cell Movements and the Shaping of the Vertebrate Body in Chapter 21 of Molecular Biology of the Cell '' fourth edition, edited by Bruce Alberts (2002) published by Garland Science. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos. It is also common to describe small molecules such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reader (academic Rank)
The title of reader in the United Kingdom and some universities in the Commonwealth of Nations, for example India, Australia and New Zealand, denotes an appointment for a senior academic with a distinguished international reputation in research or scholarship. In the traditional hierarchy of British and other Commonwealth universities, reader (and principal lecturer in the new universities) are academic ranks above senior lecturer and below professor, recognising a distinguished record of original research. Reader is similar to a professor without a chair, similar to the distinction between ''professor extraordinarius'' and ''professor ordinarius'' at some European universities, professor and chaired professor in Hong Kong and "professor name" (or associate professor) and chaired professor in Ireland. Readers and professors in the UK would correspond to full professors in the United States.Graham WebbMaking the most of appraisal: career and professional development planning for le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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