Cation Diffusion Facilitator

	Cation Diffusion Facilitator Cation diffusion facilitators (CDFs) are transmembrane proteins that provide tolerance of cells to divalent metal ions, such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these divalent metal ions from cells. However, some members of the CDF superfamily are implicated in ion uptake. All members of the CDF family possess six putative transmembrane spanners with strongest conservation in the four N-terminal spanners. The Cation Diffusion Facilitator (CDF) Superfamily includes the following families: 1.A.52- The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family 2.A.4- The Cation Diffusion Facilitator (CDF) Family 2.A.19- The Ca2+:Cation Antiporter (CaCA) Family 2.A.103- The Bacterial Murein Precursor Exporter (MPE) Family The Cation Diffusion Facilitator (CDF) Family The CDF family (TC2.A.4 is a ubiquitous family, members of which are found in bacteria, archaea and eukaryotes. They transport heavy metal ions, such as cadmiu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Transmembrane Protein A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them ( beta-barrels) can be also extracted using denaturing agents. The peptide sequence that spans the membrane, or the transmembrane segment, is largely hydrophobic and can be visualized using the hydropathy plot. Depending on the number of transmembrane segments, transmembrane proteins can be classified as single-pass membrane proteins, or as multipass membrane proteins. Some other integral membrane proteins are called monotopic, meaning that they are also permanently attached to the membrane, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Shewanella Oneidensis ''Shewanella oneidensis'' is a bacterium notable for its ability to reduce metal ions and live in environments with or without oxygen. This proteobacterium was first isolated from Lake Oneida, NY in 1988, hence its name. ''Shewanella oneidensis'' is a facultative bacterium, capable of surviving and proliferating in both aerobic and anaerobic conditions. The special interest in ''S. oneidensis'' MR-1 revolves around its behavior in an anaerobic environment contaminated by heavy metals such as iron, lead and uranium. Experiments suggest it may reduce ionic mercury to elemental mercury and ionic silver to elemental silver. Cellular respiration for these bacteria is not restricted to heavy metals though; the bacteria can also target sulfates, nitrates and chromates when grown anaerobically. Name This species is referred to as ''S. oneidensis'' MR-1, indicating "manganese reducing", a special feature of this organism. It is a common misconception to think that MR-1 refers to "me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Transmembrane Transporters A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta-barrels) can be also extracted using denaturing agents. The peptide sequence that spans the membrane, or the transmembrane segment, is largely hydrophobic and can be visualized using the hydropathy plot. Depending on the number of transmembrane segments, transmembrane proteins can be classified as single-pass membrane proteins, or as multipass membrane proteins. Some other integral membrane proteins are called monotopic, meaning that they are also permanently attached to the membrane, but do ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Transmembrane Proteins A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them ( beta-barrels) can be also extracted using denaturing agents. The peptide sequence that spans the membrane, or the transmembrane segment, is largely hydrophobic and can be visualized using the hydropathy plot. Depending on the number of transmembrane segments, transmembrane proteins can be classified as single-pass membrane proteins, or as multipass membrane proteins. Some other integral membrane proteins are called monotopic, meaning that they are also permanently attached to the membrane, bu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Membrane Proteins Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane and can either penetrate the membrane (Transmembrane protein, transmembrane) or associate with one or the other side of a membrane (Integral monotopic protein, integral monotopic). Peripheral membrane proteins are transiently associated with the cell membrane. Membrane proteins are common, and medically important—about a third of all human proteins are membrane proteins, and these are targets for more than half of all drugs. Nonetheless, compared to other classes of proteins, determining membrane protein structures remains a challenge in large part due to the difficulty in establishing experimental conditions that can preserve the correct (Native state, native) Protein structure, conformation of the protein in isolation from its native ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]