Carlos Chagas
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Carlos Chagas
Carlos Justiniano Ribeiro Chagas, or Carlos Chagas (; July 9, 1879 – November 8, 1934), was a Brazilian sanitary physician, scientist, and bacteriologist who worked as a clinician and researcher. He discovered Chagas disease, also called ''American trypanosomiasis'', in 1909, while he was working at the Oswaldo Cruz Institute in Rio de Janeiro. Chagas's work holds a unique place in the history of medicine. Working in primitive conditions, Chagas described in detail a previously-unknown infectious disease, its pathogen, vector (Triatominae), host, clinical manifestations, and epidemiology. Chagas was also the first to discover and illustrate the parasitic fungal genus ''Pneumocystis'', which later became infamous for being linked to pneumocystis pneumonia in AIDS patients. Early life Chagas was the son of José Justiniano das Chagas, a coffee farmer from Minas Gerais, and Mariana Cândida Chagas, both of Portuguese descent. After his secondary studies at Itu, São Paulo and S ...
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Carlos Chagas
Carlos Justiniano Ribeiro Chagas, or Carlos Chagas (; July 9, 1879 – November 8, 1934), was a Brazilian sanitary physician, scientist, and bacteriologist who worked as a clinician and researcher. He discovered Chagas disease, also called ''American trypanosomiasis'', in 1909, while he was working at the Oswaldo Cruz Institute in Rio de Janeiro. Chagas's work holds a unique place in the history of medicine. Working in primitive conditions, Chagas described in detail a previously-unknown infectious disease, its pathogen, vector (Triatominae), host, clinical manifestations, and epidemiology. Chagas was also the first to discover and illustrate the parasitic fungal genus ''Pneumocystis'', which later became infamous for being linked to pneumocystis pneumonia in AIDS patients. Early life Chagas was the son of José Justiniano das Chagas, a coffee farmer from Minas Gerais, and Mariana Cândida Chagas, both of Portuguese descent. After his secondary studies at Itu, São Paulo and S ...
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Scientist
A scientist is a person who conducts Scientific method, scientific research to advance knowledge in an Branches of science, area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophical study of nature called natural philosophy, a precursor of natural science. Though Thales (circa 624-545 BC) was arguably the first scientist for describing how cosmic events may be seen as natural, not necessarily caused by gods,Frank N. Magill''The Ancient World: Dictionary of World Biography'', Volume 1 Routledge, 2003 it was not until the 19th century in science, 19th century that the term ''scientist'' came into regular use after it was coined by the theologian, philosopher, and historian of science William Whewell in 1833. In modern times, many scientists have Terminal degree, advanced degrees in an area of science and pursue careers in various Sector (economic), sectors of the economy such ...
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Pneumocystis Pneumonia
''Pneumocystis'' pneumonia (PCP), also known as ''Pneumocystis jirovecii'' pneumonia (PJP), is a form of pneumonia that is caused by the yeast-like fungus ''Pneumocystis jirovecii''. ''Pneumocystis'' specimens are commonly found in the lungs of healthy people although it is usually not a cause for disease. However, they are a source of opportunistic infection and can cause lung infections in people with a weak immune system or other predisposing health conditions. PCP is seen in people with HIV/AIDS (who account for 30-40% of PCP cases), those using medications that suppress the immune system, and people with cancer, autoimmune or inflammatory conditions, and chronic lung disease. Signs and symptoms Signs and symptoms may develop over several days or weeks and may include: shortness of breath and/or difficulty breathing (of gradual onset), fever, dry/non-productive cough, weight loss, night sweats, chills, and fatigue. Uncommonly, the infection may progress to involve other vis ...
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Pneumocystis Pneumonia
''Pneumocystis'' pneumonia (PCP), also known as ''Pneumocystis jirovecii'' pneumonia (PJP), is a form of pneumonia that is caused by the yeast-like fungus ''Pneumocystis jirovecii''. ''Pneumocystis'' specimens are commonly found in the lungs of healthy people although it is usually not a cause for disease. However, they are a source of opportunistic infection and can cause lung infections in people with a weak immune system or other predisposing health conditions. PCP is seen in people with HIV/AIDS (who account for 30-40% of PCP cases), those using medications that suppress the immune system, and people with cancer, autoimmune or inflammatory conditions, and chronic lung disease. Signs and symptoms Signs and symptoms may develop over several days or weeks and may include: shortness of breath and/or difficulty breathing (of gradual onset), fever, dry/non-productive cough, weight loss, night sweats, chills, and fatigue. Uncommonly, the infection may progress to involve other vis ...
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Epidemiology
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review). Epidemiology has helped develop methodology used in clinical research, public health studies, and, to a lesser extent, basic research in the biological sciences. Major areas of epidemiological study include disease causation, transmission, outbreak investigation, disease surveillance, environmental epidemiology, forensic epidemiology, occupational epidemiology, screening, biomonitoring, and comparisons of treatment effects such as in clinical trials. ...
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Host (biology)
In biology and medicine, a host is a larger organism that harbours a smaller organism; whether a parasite, parasitic, a mutualism (biology), mutualistic, or a commensalism, commensalist ''guest'' (symbiont). The guest is typically provided with nourishment and shelter. Examples include animals playing host to parasitic worms (e.g. nematodes), cell (biology), cells harbouring pathogenic (disease-causing) viruses, a Fabaceae, bean plant hosting mutualistic (helpful) Rhizobia, nitrogen-fixing bacteria. More specifically in botany, a host plant supplies nutrient, food resources to micropredators, which have an evolutionarily stable strategy, evolutionarily stable relationship with their hosts similar to ectoparasitism. The host range is the collection of hosts that an organism can use as a partner. Symbiosis Symbiosis spans a wide variety of possible relationships between organisms, differing in their permanence and their effects on the two parties. If one of the partners in an ass ...
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Triatominae
The members of the Triatominae , a subfamily of the Reduviidae, are also known as conenose bugs, kissing bugs (so-called from their habit of feeding from around the mouths of people), or vampire bugs. Other local names for them used in The Americas include ''barbeiros'', ''vinchucas'', ''pitos'', ''chipos'' and ''chinches''. Most of the 130 or more species of this subfamily feed on vertebrate blood; a very few species feed on invertebrates. They are mainly found and widespread in the Americas, with a few species present in Asia and Africa. These bugs usually share shelter with nesting vertebrates, from which they suck blood. In areas where Chagas disease occurs (from the southern United States to northern Argentina), all triatomine species are potential vectors of the Chagas disease parasite ''Trypanosoma cruzi'', but only those species that are well adapted to living with humans (such as ''Triatoma infestans'' and ''Rhodnius prolixus'') are considered important vectors. Also, p ...
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Vector (epidemiology)
In epidemiology, a disease vector is any living agent that carries and transmits an infectious pathogen to another living organism; agents regarded as vectors are organisms, such as parasites or microbes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered the malaria pathogen when he dissected a mosquito. Arthropods Arthropods form a major group of pathogen vectors with mosquitoes, flies, sand flies, lice, fleas, ticks, and mites transmitting a huge number of pathogens. Many such vectors are haematophagous, which feed on blood at some or all stages of their lives. When the insects feed on blood, the pathogen enters the blood stream of the host. This can happen in different ways. The ''Anopheles'' mosquito, a vector for malaria, filariasis, and various arthropod-borne-viruses (arboviruses), inserts its delicate mouthpart under the skin and feeds on its host's blood. The parasites the mosquito carries are usually located in its salivary gla ...
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Pathogen
In biology, a pathogen ( el, πάθος, "suffering", "passion" and , "producer of") in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a germ. The term ''pathogen'' came into use in the 1880s. Typically, the term ''pathogen'' is used to describe an ''infectious'' microorganism or agent, such as a virus, bacterium, protozoan, prion, viroid, or fungus. Small animals, such as helminths and insects, can also cause or transmit disease. However, these animals are usually referred to as parasites rather than pathogens. The scientific study of microscopic organisms, including microscopic pathogenic organisms, is called microbiology, while parasitology refers to the scientific study of parasites and the organisms that host them. There are several pathways through which pathogens can invade a host. The principal pathways have different episodic time frames, but soil has the longest ...
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Infectious Disease
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune system. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response. Specific medications used to treat infections include antibiotics, antivirals, antifungals, antiprotozoals, and antihelminthics. Infectious diseases resulted in 9.2 million deaths in 2013 (about 17% of all deaths). The branch of medicine that focuses on infections is referred to as infectious disease. Types Infections are caused by infectious agents (pathogens) including: * Bacteria (e.g. '' Mycobacterium tuberculosis ...
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History Of Medicine
The history of medicine is both a study of medicine throughout history as well as a multidisciplinary field of study that seeks to explore and understand medical practices, both past and present, throughout human societies. More than just history and medicine, this field of study incorporates learnings from across disciplines such as anthropology, economics, health sciences, sociology, and politics to better understand the institutions, practices, people, professions, and social systems that have influenced and shaped medicine throughout the ages. As a documentation of medicine over time, the history of medicine shows how societies have changed in their approach to illness and disease from ancient times to the present. Early medical traditions include those of Babylon, China, Egypt and India. The Hippocratic Oath was written in ancient Greece in the 5th century BCE, and is a direct inspiration for oaths of office that physicians swear upon entry into the profession today. In ...
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Rio De Janeiro
Rio de Janeiro ( , , ; literally 'River of January'), or simply Rio, is the capital of the state of the same name, Brazil's third-most populous state, and the second-most populous city in Brazil, after São Paulo. Listed by the GaWC as a beta global city, Rio de Janeiro is the sixth-most populous city in the Americas. Part of the city has been designated as a World Heritage Site, named "Rio de Janeiro: Carioca Landscapes between the Mountain and the Sea", on 1 July 2012 as a Cultural Landscape. Founded in 1565 by the Portuguese, the city was initially the seat of the Captaincy of Rio de Janeiro, a domain of the Portuguese Empire. In 1763, it became the capital of the State of Brazil, a state of the Portuguese Empire. In 1808, when the Portuguese Royal Court moved to Brazil, Rio de Janeiro became the seat of the court of Queen Maria I of Portugal. She subsequently, under the leadership of her son the prince regent João VI of Portugal, raised Brazil to the dignity of a k ...
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