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Carbolabs
Carbolabs, Inc., is an American chemistry company specializing in reactions utilizing phosgene, founded by Joe Karabinos in 1967. Originally located in the basement of his home in Bethany, Connecticut, it wasn't until the following year that the business was moved into its own dedicated building. The company was purchased by Sigma Aldrich in 1998. In 2008 operations at the Bethany site were discontinued and were subsequently moved to the Sheboygan Falls, Wisconsin Sigma Aldrich manufacturing facility. Carbolabs uses phosgene to produce a wide array of chemicals including isocyanates, chloroformates, and isonitriles, although some reactions not involving phosgene such as the production of the fluorinating reagent DAST are also part of their established chemistries. As a subsidiary of Sigma Aldrich Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company that is owned by the German chemical conglomerate Merck Group. Sigma-Aldrich ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigma-Aldrich
Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company that is owned by the German chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company and Aldrich Chemical Company. It grew through various acquisitions until it had over 9,600 employees and was listed on the Fortune 1000. The company is headquartered in St. Louis and has operations in approximately 40 countries. In 2015, the German chemical conglomerate Merck Group acquired Sigma-Aldrich for $17 billion. The company is currently a part of Merck's life science business and in combination with Merck's earlier acquired Millipore Corporation, Millipore, operates as MilliporeSigma. History Sigma Chemical Company of St. Louis and Aldrich Chemical Company of Milwaukee were both American specialty chemical companies when they merged in August 1975. The company grew throughout the 1980s and 1990s, with significant expansion in fac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigma Aldrich
Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company that is owned by the German chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company and Aldrich Chemical Company. It grew through various acquisitions until it had over 9,600 employees and was listed on the Fortune 1000. The company is headquartered in St. Louis and has operations in approximately 40 countries. In 2015, the German chemical conglomerate Merck Group acquired Sigma-Aldrich for $17 billion. The company is currently a part of Merck's life science business and in combination with Merck's earlier acquired Millipore, operates as MilliporeSigma. History Sigma Chemical Company of St. Louis and Aldrich Chemical Company of Milwaukee were both American specialty chemical companies when they merged in August 1975. The company grew throughout the 1980s and 1990s, with significant expansion in facilities, acquisitions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diethylaminosulfur Trifluoride
Diethylaminosulfur trifluoride (DAST) is the organosulfur compound with the formula Et2NSF3. This liquid is a fluorinating reagent used for the synthesis of organofluorine compounds. The compound is colourless; older samples assume an orange colour. Use in organic synthesis DAST converts alcohols to the corresponding alkyl fluorides as well as aldehydes and unhindered ketones to geminal difluorides. Carboxylic acids react no further than the acyl fluoride (sulfur tetrafluoride effects the transformation —CO2H → —CF3). DAST is used in preference to the more classical gaseous SF4, since as a liquid it is more easily handled. A slightly thermally more stable compound is morpho-DAST. Acid-labile substrates are less likely to undergo rearrangement and elimination since DAST is less prone to contamination with acids. Reaction temperatures are milder as well – alcohols typically react at −78 °C and ketones around 0 °C. Synthesis DAST is prepared by the reaction of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosgene
Phosgene is the organic chemical compound with the formula COCl2. It is a toxic, colorless gas; in low concentrations, its musty odor resembles that of freshly cut hay or grass. Phosgene is a valued and important industrial building block, especially for the production of precursors of polyurethanes and polycarbonate plastics. Phosgene is extremely poisonous and was used as a chemical weapon during World War I, where it was responsible for 85,000 deaths. It was a highly potent pulmonary irritant and quickly filled enemy trenches due to it being a heavy gas. It is classified as a Schedule 3 substance under the Chemical Weapons Convention. In addition to its industrial production, small amounts occur from the breakdown and the combustion of organochlorine compounds, such as chloroform. Structure and basic properties Phosgene is a planar molecule as predicted by VSEPR theory. The C=O distance is 1.18 Å, the C−Cl distance is 1.74 Å and the Cl−C−Cl angle is 111 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bethany, Connecticut
Bethany is a town in New Haven County, Connecticut, United States. The population was 5,297 at the 2020 census. History Bethany was first settled in 1717, but it was not until May 1832 that Bethany separated from Woodbridge to become incorporated as a town. This slightly remote, sparsely populated, residential town retains its rural character. There is some dairying and agriculture. The town is dotted with reservoirs serving Naugatuck and, principally, New Haven. There have been inhabitants in Bethany since before 1638, predominantly Naugatucks of the Paugusset tribe and Mattabessitts of the Wanguck tribe. The first European settlers arrived in the area around April 1638, creating the towns of Milford and New Haven, with their boundary split down the middle of what is now Bethany. The area of the boundary was settled in 1678, twelve years after New Haven County was organized. In 1717, the Amity Parish was accepted by the General Assembly of the Connecticut Colony and in 1832, Be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sheboygan Falls, Wisconsin
Sheboygan Falls is a city in Sheboygan County, Wisconsin, United States. Its population was 8,210 at the 2020 census. The city's downtown is listed on the National Register of Historic Places and is the first Main Street Community in Wisconsin. The city is part of the Sheboygan, Wisconsin Metropolitan Statistical Area. History Sheboygan Falls took its name from the nearby falls on the Sheboygan River. The city was called Rochester for a brief time; the name was changed because a community in Racine County already held the same name. Geography Sheboygan Falls is located along the Sheboygan River between its confluences with the Mullet and Onion Rivers near Lake Michigan. Rapids and a dam, which once supplied hydroelectric energy, prohibit most water transportation through the city. According to the United States Census Bureau, the city has a total area of , of which, is land and is water. Demographics 2010 census As of the census of 2010, there were 7,775 people, 3,48 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isocyanates
In organic chemistry, isocyanate is the functional group with the formula . Organic compounds that contain an isocyanate group are referred to as isocyanates. An organic compound with two isocyanate groups is known as a diisocyanate. Diisocyanates are manufactured for the production of polyurethanes, a class of polymers. Isocyanates should not be confused with cyanate esters and isocyanides, very different families of compounds. The cyanate (cyanate ester) functional group () is arranged differently from the isocyanate group (). Isocyanides have the connectivity , lacking the oxygen of the cyanate groups. Structure and bonding In terms of bonding, isocyanates are closely related to carbon dioxide (CO2) and carbodiimides (C(NR)2). The C−N=C=O unit that defines isocyanates is planar, and the N=C=O linkage is nearly linear. In phenyl isocyanate, the C=N and C=O distances are respectively 1.195 and 1.173 Å. The C-N=C angle is 134.9° and the N=C=O angle is 173.1°. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloroformates
Chloroformates are a class of organic compounds with the formula ROC(O)Cl. They are formally esters of chloroformic acid. Most are colorless, volatile liquids that degrade in moist air. A simple example is methyl chloroformate, which is commercially available. Chloroformates are used as reagents in organic chemistry. For example, benzyl chloroformate is used to introduce the Cbz (carboxybenzyl) protecting group and fluorenylmethyloxycarbonyl chloride is used to introduce the FMOC protecting group. Chloroformates are popular in the field of chromatography as derivatization agents. They convert polar compounds into less polar more volatile derivatives. In this way, chloroformates enable relatively simple transformation of large array of metabolites (aminoacids, amines, carboxylic acids, phenols) for analysis by gas chromatography / mass spectrometry. Reactions The reactivity of chloroformates and acyl chlorides are similar. Representative reactions are: * Reaction with amines to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isonitriles
An isocyanide (also called isonitrile or carbylamine) is an organic compound with the functional group –. It is the isomer of the related nitrile (–C≡N), hence the prefix is ''isocyano''.IUPAC Goldboo''isocyanides''/ref> The organic fragment is connected to the isocyanide group through the nitrogen atom, not via the carbon. They are used as building blocks for the synthesis of other compounds. Properties Structure and bonding The C-N distance in isocyanides is 115.8 pm in methyl isocyanide. The C-N-C angles are near 180°. Akin to carbon monoxide, isocyanides are described by two resonance structures, one with a triple bond between the nitrogen and the carbon and one with a double bond between. The π lone pair of the nitrogen stabilizes the structure and is responsible of the linearity of isocyanides, although the reactivity of isocyanides reflects some carbene character, at least in a formal sense. Thus, both resonance structures are useful representations. They are sus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merck Group
The Merck Group, branded and commonly known as Merck, is a German multinational science and technology company headquartered in Darmstadt, with about 60,000 employees and present in 66 countries. The group includes around 250 companies; the main company is Merck KGaA in Germany. The company is divided into three business lines: Healthcare, Life Sciences and Electronics. Merck was founded in 1668 and is the world's oldest operating chemical and pharmaceutical company, as well as one of the largest pharmaceutical companies in the world. Merck operates in Europe, Africa, Asia, Oceania and the Americas. It has major research and development centres in Darmstadt, Boston, Tokyo and Beijing, as well as other Research and Development units in Taiwan, France, Israel, South Korea, India and in the UK. Merck pioneered the commercial manufacture of morphine in the 19th century and for a time held a virtual monopoly on cocaine. Merck was privately owned until going public on the Frankfu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Specialty Chemical Companies , a dog show of a single breed
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Specialty or speciality may refer to: * Deed, a contract in law * Index of speciality, a geometrical invariant * ''Speciality'' (album), an album by J-Pop singer Nami Tamaki * Specialty (medicine), a field within medicine * Specialty (dentistry), a field within dentistry * Specialty Records, a record label * Specialty show A specialty show is a dog show which reviews a single breed, unlike other dog shows, particularly conformation shows, which are generally referred to as "all-breed" because they are open to all breeds recognized by the sponsoring kennel club. A sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Companies Of The United States
A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., without breaking chemical bonds. Chemical substances can be simple substances (substances consisting of a single chemical element), chemical compounds, or alloys. Chemical substances are often called 'pure' to set them apart from mixtures. A common example of a chemical substance is pure water; it has the same properties and the same ratio of hydrogen to oxygen whether it is isolated from a river or made in a laboratory. Other chemical substances commonly encountered in pure form are diamond (carbon), gold, table salt (sodium chloride) and refined sugar (sucrose). However, in practice, no substance is entirely pure, and chemical purity is specified according to the intended use of the chemical. Chemical substances exist as solids, liquids, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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