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Canine Minute Virus
''Carnivore bocaparvovirus 1'', formerly ''Canine minute virus'' (or minute virus of canines; MVC) is a species of ''Bocaparvovirus'' of the family '' Parvoviridae'' that infects dogs. It is similar to ''bovine parvovirus'' in its protein structure and DNA. A virus causing respiratory disease in humans has been called ''human bocavirus'' due to its similarity to these viruses. Canine minute virus was originally discovered in Germany in 1967 in military dogs, although it was originally thought to not cause disease. Dogs and puppies are infected orally, and the virus is spread transplacentally to the fetuses. Symptoms are seen most commonly between the ages of one to three weeks and include severe diarrhea, difficulty breathing, and anorexia. In severe cases, illness can be fatal. In experimental infections, the virus is spread transplacentally when the dam is infected between 25 and 30 days of gestation and can result in abortion. When the dam is infected between 30 and 35 days, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bocaparvovirus
''Bocaparvovirus'' is a genus of viruses in the subfamily ''Parvovirinae'' of the virus family ''Parvoviridae''. Humans, cattle, and dogs serve as natural hosts. There are 28 species in this genus. Diseases associated with this genus include, in humans, acute respiratory illness, and in cattle, diarrhea and mild respiratory symptoms. History Bocaviruses were first described in animals in the early 1960s. Genome Like the other members of this family, bocaparvoviruses have two open reading frames—ORF1 and 2. Unique among parvoviruses, the bocaparvoviruses contain a third open reading frame between non-structural and structural coding regions. This gene encodes a highly phosphorylated nonstructural protein (NP1). ORF1 encodes a nonstructural protein (NS1) that is involved in viral genome replication. ORF2 encodes the two capsid proteins—VP1 and VP2. Like other parvoviruses, the VP1 unique region contains a phospholipase A(2) motif with a conserved Histidine– Aspartic acid-X ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parvoviridae
Parvoviruses are a family of animal viruses that constitute the family ''Parvoviridae''. They have linear, single-stranded DNA (ssDNA) genomes that typically contain two genes encoding for a replication initiator protein, called NS1, and the protein the viral capsid is made of. The coding portion of the genome is flanked by telomeres at each end that form into hairpin loops that are important during replication. Parvovirus virions are small compared to most viruses, at 23–28 nanometers in diameter, and contain the genome enclosed in an icosahedral capsid that has a rugged surface. Parvoviruses enter a host cell by endocytosis, travelling to the nucleus where they wait until the cell enters its replication stage. At that point, the genome is uncoated and the coding portion is replicated. Viral messenger RNA (mRNA) is then transcribed and translated, resulting in NS1 initiating replication. During replication, the hairpins repeatedly unfold, are replicated, and refold to chang ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bovine Parvovirus
''Ungulate bocaparvovirus 1'', formerly ''Bovine parvovirus'' (BPV), also known as Haemadsorbing enteric Virus, is a member of the parvovirus group, with three significant sub-species: BPV1, 2 and 3. BPV most commonly causes diarrhea in neonatal calves and respiratory and reproductive disease in adult cattle. The distribution of the virus is worldwide. Transmission is both vertical (transplacental route) and horizontal ( oro-fecal route). The virus is very resistant to chemical and physical challenges. Clinical signs and diagnosis Diarrhea is often the only clinical sign in neonatal calves. Reproductive infection causes abortion and the birth of weak or stillborn calves. Respiratory signs such as coughing, dyspnea, and nasal discharge also can occur. The clinical signs of BPV may be made worse by concurrent GI infections. Immunofluorescence (IF), PCR, hemagglutination, ELISA and electron microscopy can be used to identify the virus. Aborted fetuses are edematous and have inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Bocavirus
Human bocavirus (HBoV) is the name given to all viruses in the genus ''Bocaparvovirus'' of virus family ''Parvoviridae'' that are known to infect humans. HBoV1 and HBoV3 (and gorilla bocaparvovirus) are members of species '' Primate bocaparvovirus 1'' whereas viruses HBoV2 and HBoV4 belong to species '' Primate bocaparvovirus 2''. Some of these viruses cause human disease. HBoV1 is strongly implicated in causing some cases of lower respiratory tract infection, especially in young children, and several of the viruses have been linked to gastroenteritis, although the full clinical role of this emerging infectious disease remains to be elucidated. History Allander and colleagues at the Karolinska Institutet in Stockholm, Sweden, first cloned the coding sequence of this new member of the family of ''Parvoviridae'' in 2005 from pooled nasopharyngeal aspirates (NPA, collection of aspirated fluid from the back of the nasal cavity). They used a novel technique called molecular virus sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diarrhea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin with loss of the normal stretchiness of the skin and irritable behaviour. This can progress to decreased urination, loss of skin color, a fast heart rate, and a decrease in responsiveness as it becomes more severe. Loose but non-watery stools in babies who are exclusively breastfed, however, are normal. The most common cause is an infection of the intestines due to either a virus, bacterium, or parasite—a condition also known as gastroenteritis. These infections are often acquired from food or water that has been contaminated by feces, or directly from another person who is infected. The three types of diarrhea are: short duration watery diarrhea, short duration bloody diarrhea, and persistent diarrhea (lasting more than two weeks, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anorexia (symptom)
Anorexia is a medical term for a loss of appetite. While the term in non-scientific publications is often used interchangeably with anorexia nervosa, many possible causes exist for a loss of appetite, some of which may be harmless, while others indicate a serious clinical condition or pose a significant risk. Anorexia is a symptom, not a diagnosis. Anorexia is not to be confused with the mental health disorder anorexia nervosa. Because the term 'anorexia' is often used as a short-form of anorexia nervosa, to avoid confusion a provider must clarify to a patient whether they are simply referring to a decreased appetite or the mental health disorder. Anyone can manifest anorexia as a loss of appetite, regardless of their gender, age, or weight. The symptom also occurs in other animals, such as cats, dogs, cattle, goats, and sheep. In these species, anorexia may be referred to as inappetence. As in humans, loss of appetite can be due to a range of diseases and conditions, as well as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mother
] A mother is the female parent of a child. A woman may be considered a mother by virtue of having given childbirth, birth, by raising a child who may or may not be her biological offspring, or by supplying her ovum for fertilisation in the case of gestational surrogacy. An adoptive mother is a female who has become the child's parent through the legal process of adoption. A biological mother is the female genetic contributor to the creation of the infant, through sexual intercourse or egg donation. A biological mother may have legal obligations to a child not raised by her, such as an obligation of monetary support. A putative mother is a female whose biological relationship to a child is alleged but has not been established. A stepmother is a woman who is married to a child's father and they may form a family unit, but who generally does not have the legal rights and responsibilities of a parent in relation to the child. A father is the male counterpart of a mother. Women who ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myocarditis
Myocarditis, also known as inflammatory cardiomyopathy, is an acquired cardiomyopathy due to inflammation of the heart muscle. Symptoms can include shortness of breath, chest pain, decreased ability to exercise, and an irregular heartbeat. The duration of problems can vary from hours to months. Complications may include heart failure due to dilated cardiomyopathy or cardiac arrest. Myocarditis is most often due to a viral infection. Other causes include bacterial infections, certain medications, toxins and autoimmune disorders. A diagnosis may be supported by an electrocardiogram (ECG), increased troponin, heart MRI, and occasionally a heart biopsy. An ultrasound of the heart is important to rule out other potential causes such as heart valve problems. Treatment depends on both the severity and the cause. Medications such as ACE inhibitors, beta blockers, and diuretics are often used. A period of no exercise is typically recommended during recovery. Corticosteroids or int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anasarca
Anasarca is a severe and generalized form of edema, with subcutaneous tissue swelling throughout the body. Unlike typical edema, which almost everyone will experience at some time and can be relatively benign, anasarca is a pathological process reflecting a severe disease state and can involve the cavities of the body in addition to the tissues. Signs and symptoms Physical appearance Can include: * Periorbital edema " eye puffiness" * Perioral edema * Upper extremity edema * Ascites * Lower extremity edema * Pre-tibial edema * Pedal edema Physical manifestations Can include: * Impaired vision, difficulty opening eyes * Shortness of breath (SOB), dyspnea on exertion (DOE), orthopnea * Chest pain * Extreme discomfort * Debilitation Cause Anasarca is often caused by a decreased oncotic pressure. Organ failure * Liver failure * Kidney failure * Right-sided heart failure Malignancy Diet * Severe protein deficiency Systemic manifestations of * Nephrotic synd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathology
Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"), and the affix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lung
The lungs are the primary organs of the respiratory system in humans and most other animals, including some snails and a small number of fish. In mammals and most other vertebrates, two lungs are located near the backbone on either side of the heart. Their function in the respiratory system is to extract oxygen from the air and transfer it into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere, in a process of gas exchange. Respiration is driven by different muscular systems in different species. Mammals, reptiles and birds use their different muscles to support and foster breathing. In earlier tetrapods, air was driven into the lungs by the pharyngeal muscles via buccal pumping, a mechanism still seen in amphibians. In humans, the main muscle of respiration that drives breathing is the diaphragm. The lungs also provide airflow that makes vocal sounds including human speech possible. Humans have two lungs, one on the left and on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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