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Calphostin C
Calphostin C is a natural chemical compound. It is one of the calphostins, isolated from the fungus ''Cladosporium cladosporioides''. Calphostin C is a potent enzyme inhibitor, inhibitor of protein kinase C (PKC). References External links O-methylated natural phenols Cladosporium Protein kinase inhibitors Benzoate esters 3-Hydroxypropenals within hydroxyquinones {{Aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calphostin
The calphostins are a class of closely related chemical compounds isolated from the fungus ''Cladosporium cladosporioides''. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are enzyme inhibitor, inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity. at Biomol Calphostin C Calphostin C is a potent enzyme inhibitor, inhibitor of protein kinase C (PKC).References External links *{{Commonscat-inline, Calphostins O-methylated natural phenols Cladosporium 3-Hydroxypropenals within hydroxyquinones ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cladosporium Cladosporioides
''Cladosporium cladosporioides'' is a darkly pigmented mold that occurs world-wide on a wide range of materials both outdoors and indoors. It is one of the most common fungi in outdoor air where its spores are important in seasonal allergic disease. While this species rarely causes invasive disease in animals, it is an important agent of plant disease, attacking both the leaves and fruits of many plants. This species produces asexual spores in delicate, branched chains that break apart readily and drift in the air. It is able to grow under low water conditions and at very low temperatures. History and classification Georg Fresenius first described ''Cladosporium cladosporioides'' in 1850, classifying it in the genus ''Penicillium'' as ''Penicillium cladosporioides''. In 1880 Pier Andrea Saccardo renamed the species, ''Hormodendrum cladosporioides''. Other early names for this taxon included ''Cladosporium hypophyllum'', ''Monilia humicola'' and ''Cladosporium pisicola''. In 1952 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products. An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction. An enzyme inhibitor stops ("inhibits") this process, either by binding to the enzyme's active site (thus preventing the substrate itself from binding) or by binding to another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. Enzyme inhibitors may bind reversibly or irreversibly. Irreversible inhibitors form a chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. By contrast, reversible inhibitors bind non-covalently and may spontaneously leave the enzyme, allowing the enzyme to resume its function. Reve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase C
In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. In biochemistry, the PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cladosporium
''Cladosporium'' is a genus of fungi including some of the most common indoor and outdoor molds. Species produce olive-green to brown or black colonies, and have dark-pigmented conidia that are formed in simple or branching chains. Many species of ''Cladosporium'' are commonly found on living and dead plant material. Some species are endophytes or plant pathogens, while others parasitize fungi. ''Cladosporium'' spores are wind-dispersed and they are often extremely abundant in outdoor air. Indoors ''Cladosporium'' species may grow on surfaces when moisture is present. '' Cladosporium fulvum'', cause of tomato leaf mould, has been an important genetic model, in that the genetics of host resistance are understood. In the 1960s, it was estimated that the genus ''Cladosporium'' contained around 500 plant-pathogenic and saprotrophic species, but this number has since been increased to over 772 species. The genus ''Cladosporium'' is very closely related to black yeasts in the order Do ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase Inhibitors
A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO4, group) to a protein and can modulate its function. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein: most kinases act on both serine and threonine, the tyrosine kinases act on tyrosine, and a number (dual-specificity kinases) act on all three. There are also protein kinases that phosphorylate other amino acids, including histidine kinases that phosphorylate histidine residues. Phosphorylation regulates many biological processes, and protein kinase inhibitors can be used to treat diseases due to hyperactive protein kinases (including mutant or overexpressed kinases in cancer) or to modulate cell functions to overcome other disease drivers. Clinical use Kinase inhibitors such as dasatinib are often used in the treatment of cancer and inflammation. So ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzoate Esters
Benzoic acid is a white (or colorless) solid organic compound with the formula , whose structure consists of a benzene ring () with a carboxyl () substituent. It is the simplest aromatic carboxylic acid. The name is derived from gum benzoin, which was for a long time its only source. Benzoic acid occurs naturally in many plants and serves as an intermediate in the biosynthesis of many secondary metabolites. Salts of benzoic acid are used as food preservatives. Benzoic acid is an important precursor for the industrial synthesis of many other organic substances. The salts and esters of benzoic acid are known as benzoates . History Benzoic acid was discovered in the sixteenth century. The dry distillation of gum benzoin was first described by Nostradamus (1556), and then by Alexius Pedemontanus (1560) and Blaise de Vigenère (1596). Justus von Liebig and Friedrich Wöhler determined the composition of benzoic acid. These latter also investigated how hippuric acid is related ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
