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CTF8
Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the ''CHTF8'' gene. This gene encodes a short protein that forms part of the CHTF18, Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternative splicing results in multiple variants encoding different isoforms. This gene has a pseudogene on chromosome X. References External links * Further reading * * * * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CHTF18
Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the ''CHTF18'' gene. Interactions CHTF18 has been shown to interact with: * DCC1, * PCNA, * RFC2, * RFC3, * RFC4, and * RFC5 Replication factor C subunit 5 is a protein that in humans is encoded by the ''RFC5'' gene. Function The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell .... References External links * Further reading * * * * * * {{gene-16-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |