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CRISPR Immune System
CRISPR () (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryote, prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes and provide a form of acquired immunity. CRISPR is found in approximately 50% of sequenced bacterial genomes and nearly 90% of sequenced archaea. Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and cleave specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR gene editing, CRISPR-Cas9 that can be used to edit gene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osaka University
, abbreviated as , is a public research university located in Osaka Prefecture, Japan. It is one of Japan's former Imperial Universities and a Designated National University listed as a "Top Type" university in the Top Global University Project. The university is often ranked among the top three public universities in Japan, along with the University of Tokyo and Kyoto University. It is ranked third overall among Japanese universities and 75th worldwide in the 2022 QS World University Rankings. Osaka University was one of the earliest modern universities in Japan at its founding in 1931. The history of the institution includes much older predecessors in Osaka such as the Kaitokudō founded in 1724 and the Tekijuku founded in 1838. In 2007, it merged with Osaka University of Foreign Studies and became the largest national university in Japan. Osaka University is one of the most productive research institutions in Japan. Numerous prominent scholars and scientists have attended or w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yogurt
Yogurt (; , from tr, yoğurt, also spelled yoghurt, yogourt or yoghourt) is a food produced by bacterial Fermentation (food), fermentation of milk. The bacteria used to make yogurt are known as ''yogurt cultures''. Fermentation of sugars in the milk by these bacteria produces lactic acid, which acts on milk protein to give yogurt its texture (food), texture and characteristic tart flavor. Cow's milk is the milk most commonly used to make yogurt. Milk from water buffalo, goats, sheep, ewes, mares, camels, and yaks are also used to produce yogurt. The milk used may be Milk#Creaming and homogenization, homogenized or not. It may be pasteurized or raw milk, raw. Each type of milk produces substantially different results. Yogurt is produced using a culture of Lactobacillus delbrueckii subsp. bulgaricus, ''Lactobacillus delbrueckii'' subsp. ''bulgaricus'' and ''Streptococcus thermophilus'' bacteria. In addition, other Lactobacillus, lactobacilli and Bifidobacterium, bifidobacteria a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Archaeoglobus Fulgidus
''Archaeoglobus'' is a genus of the phylum Euryarchaeota. ''Archaeoglobus'' can be found in high-temperature oil fields where they may contribute to oil field souring. Metabolism ''Archaeoglobus'' grow anaerobically at extremely high temperatures between 60 and 95 °C, with optimal growth at 83 °C (ssp. ''A. fulgidus'' VC-16). They are sulfate-reducing archaea, coupling the reduction of sulfate to sulfide with the oxidation of many different organic carbon sources, including complex polymers. ''A. lithotrophicus'' live chemolitho-autotrophically from hydrogen, sulfate and carbon dioxide. Also ''A. profundus'' grow lithotrophically, but while this species needs acetate and CO2 for biosynthesis they are heterotroph. The complete ''A. fulgidus'' genome sequence revealed the presence of a nearly complete set of genes for methanogenesis. The function of these genes in ''A. fulgidus'' remains unknown, while the lack of the enzyme methyl-CoM reductase does not allow for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ruud Jansen
Ruud and Rud are surnames of Norwegian origin. Both are also Norwegian place names of numerous farmsteads named Rud or Ruud from Old Norse ''ruð'' meaning clearing. Ruud is also a Dutch masculine given name meaning "famous wolf" although it is also often short for Rudolf. Ruud * Asbjørn Ruud (1919–1986), Norwegian ski jumper * Barrett Ruud (born 1983), American football linebacker * Birger Ruud (1911–1998), Norwegian ski jumper * Bo Ruud (born 1984), American football linebacker * Casper Ruud (born 1998), Norwegian tennis player * Christian Ruud (born 1972), Norwegian tennis player * David Ruud (born 1980), Swedish motorcycle speedway rider * Edwin Ruud (1854–1932), Norwegian-American mechanical engineer and inventor * Espen Ruud (born 1984), Norwegian football defender * Joseph Ruud (born 1981), American professional wrestler better known as (Erick) Rowan * Maria Ruud (born 1960), American politician and a member of the Minnesota House of Representatives * Millard Ru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haloferax Volcanii
''Haloferax volcanii'' is a species of organism in the genus ''Haloferax'' in the Archaea. Description and significance Microbiologist Benjamin Elazari Volcani first discovered ''Haloferax volcanii'', a self-named extremophile, in the 1930s. ''H. volcanii'' is a halophilic mesophile archaeon that can be isolated from hypersaline environments such as: the Dead Sea, the Great Salt Lake, and oceanic environments with high sodium chloride concentrates. ''Haloferax volcanii'' is noteworthy because it can be cultured without much difficulty, rare for an extremophile. ''H. volcanii'' is chemoorganotrophic, metabolizing sugars as a carbon source. It is primarily aerobic, but is capable of anaerobic respiration under anoxic conditions. Recently an isolate of this species was studied by researchers at University of California, Berkeley, as part of a project on the survival of haloarchaea on Mars. Genome structure The genome of ''H. volcanii'' consists of a large (4 Mb), multicopy chrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haloarcula
''Haloarcula'' (common abbreviation ''Har.'') is a genus of extreme halophilic Archaea in the class of Halobactaria. Cell Structure ''Haloarcula'' species can be distinguished from other genera in the family Halobacteriaceae by the presence of specific derivatives of TGD-2 polar lipids. ''H. quadrata'' has predominantly flat, square-shaped, somewhat pleomorphic cells. Metabolism ''H. quadrata'' was first isolated when researchers were attempting to culture ''Haloquadratum walsbyi'', a haloarchaeon that was thought to be unculturable until 2004. Similar to other halophilic archaea, ''Haloarcula'' species grow optimally at 40–45 °C. Growth appears in sheets of up to 65 cells often in the shape of a square or triangle. Taxonomy The genus of ''Haloarcula'' was long grouped with other halophilic archaea such as '' Halobacterium'' until genomic analysis prompted to reorder this genus in the new family of Haloarculaceae. Ecology ''Haloarcula'' species are found in neutral ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haloferax
In taxonomy, ''Haloferax'' (common abbreviation: ''Hfx.'') is a genus of the Haloferacaceae. Genetic exchange Cells of ''H. mediterranei'' and cells of the related species '' H. volcanii'' can undergo a process of genetic exchange between two cells which involves cell fusion resulting in a heterodiploid cell (containing two different chromosomes in one cell). Although this genetic exchange ordinarily occurs between two cells of the same species, it can also occur at a lower frequency between an ''H. mediterranei'' and an ''H. volcani'' cell. These two species have an average nucleotide sequence identity of 86.6%. During this exchange process, a diploid cell is formed that contains the full genetic repertoire of both parental cells, and genetic recombination is facilitated. Subsequently, the cells separate, giving rise to recombinant cells. Taxonomy As of 2022, 13 species are validly published under the genus ''Haloferax''. ;Proposed species Several species and novel binomial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Alicante
The University of Alicante ( ca-valencia, Universitat d'Alacant, italic=no, ; es, Universidad de Alicante, italic=no, ; also known by the acronym ''UA'') was established in 1979 on the basis of the Center for University Studies (CEU), which was founded in 1968. The university main campus is located in San Vicente del Raspeig/Sant Vicent del Raspeig, bordering the city of Alicante to the north. As of 2011/12 academic year, there are approximately 27,500 students studying there. History The university inherits the legacy of the University of Orihuela that was established by Papal Bull in 1545 and remained open for two centuries (1610-1808). Studies The University of Alicante offers courses in more than fifty degrees. It comprises over seventy departments and research groups in areas of Social Science and Law, Experimental science, Technology, Liberal Arts, Education and Health Sciences, and five research institutes. Almost all classes are taught in Spanish language, some are in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francisco Mojica
Francisco Juan Martínez Mojica (born 5 October 1963) is a Spanish molecular biologist and microbiologist at the University of Alicante in Spain. He is known for his discovery of repetitive, functional DNA sequences in bacteria which he named CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). These were later developed into the first widespread genome editing tool, CRISPR-Cas9. Early life and education Mojica was born in Elche, Spain, on 5 October 1963. He attended Los Andes elementary school, Vázquez de Mella school, and Instituto Carrus high school. He enrolled first at the University of Murcia to study biology and later moved to the University of Valencia ( BS, 1986) and University of Alicante ( PhD, 1993). During his doctoral studies, he visited Paris-Sud University. He then received post-doctoral training at the University of Utah and the University of Oxford. Since 1994, Mojica has been a faculty member at the University of Alicante, were he has focused ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Direct Repeat
Direct repeats are a type of genetic sequence that consists of two or more repeats of a specific sequence. In other words, the direct repeats are nucleotide sequences present in multiple copies in the genome. Generally, a direct repeat occurs when a sequence is repeated with the same pattern downstream. There is and no reverse complement associated with a direct repeat. It may or may not have intervening nucleotides. The nucleotide sequence written in bold characters signifies the repeated sequence. ::: ::: Linguistically, a typical direct repeat is comparable to saying "bye-bye". Types There are several types of repeated sequences : *Interspersed (or dispersed) DNA repeats (interspersed repetitive sequences) are copies of transposable elements interspersed throughout the genome. *Flanking (or terminal) repeats (terminal repeat sequences) are sequences that are repeated on both ends of a sequence, for example, the long terminal repeats (LTRs) on retroviruses. Direct terminal rep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
