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CD3EAP
DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the ''CD3EAP'' gene. Interactions CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the ''CD3E'' gene which resides on chromosome 11. Function The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, ..., POLR1E and POLR1C. References Further reading * * * * * * * * External links * * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T-cell Surface Glycoprotein CD3 Epsilon Chain
CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the ''CD3E'' gene which resides on chromosome 11. Function The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor- CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Clinical significance Defects in this gene cause severe immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. Interactions T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2. See also * CD3 (immunology) * Cluster of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
POLR1E
DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the ''POLR1E'' gene. Model organisms Model organisms have been used in the study of POLR1E function. A conditional knockout mouse line, called ''Polr1etm1a(KOMP)Wtsi'' was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals. Interactions POLR1E has been shown to interact with CD3EAP and POLR1C DNA-direct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
