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C. Robin Ganellin
Charon Robin Ganellin FRS (25 January 1934 – ) is a British medicinal chemist, and Emeritus Smith Kline and French Professor of Medicinal Chemistry, at University College London. He has contributed much to the field of drug discovery and development. His most outstanding achievement was the discovery of cimetidine, a drug used to combat stomach ulcers, when he was working at Smith Kline and French.Ganellin, C. Robin. Drug Discovery Today, Feb 2004, Vol. 9 Issue 4, p158, 3p He has received many awards and much recognition for his scientific pursuits over the years. He now lives near London and is a professor at University College London. Early life Born in East London on 1934 January 25, Charon Robin Ganellin knew from an early age that his calling was chemistry. During his studies at Harrow County School for Boys, he developed a strong aptitude for science and maths, but his performance in language and history was lacking. Although he enjoyed biology and natural history a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicinal Chemistry
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry. Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant ant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guanidine
Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine predominantly in patients experiencing renal failure. A guanidine moiety also appears in larger organic molecules, including on the side chain of arginine. Structure Guanidine can be thought of as a nitrogenous analogue of carbonic acid. That is, the C=O group in carbonic acid is replaced by a C=NH group, and each OH is replaced by a group. Isobutene can be seen as the carbon analogue in much the same way. A detailed crystallographic analysis of guanidine was elucidated 148 years after its first synthesis, despite the simplicity of the molecule. In 2013, the positions of the hydrogen atoms and their displacement parameters were accurately determined using single-crystal neutron diffraction. Production Guanidine can be obtained from natural sources, being first isolat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Historic Chemical Landmarks
The National Historic Chemical Landmarks program was launched by the American Chemical Society in 1992 to recognize significant achievements in the history of chemistry and related professions. The program celebrates the The central science, centrality of chemistry. The designation of such generative achievements in the history of chemistry demonstrates how chemists have benefited society by fulfilling the ACS vision: Improving people's lives through the transforming power of chemistry. The program occasionally designates International Historic Chemical Landmarks to commemorate "chemists and chemistry from around the world that have had a major impact in the United States". List of landmarks 1993 *Bakelite, the world's first completely synthetic plastic, developed by Leo Baekeland around 1907 1994 *List of Lehigh University buildings#Chandler-Ullmann Hall (1883, 1938), Chandler Chemistry Laboratory at Lehigh University, constructed in 1884 *Joseph Priestley House, U.S. home of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Inventors Hall Of Fame
The National Inventors Hall of Fame (NIHF) is an American not-for-profit organization, founded in 1973, which recognizes individual engineers and inventors who hold a U.S. patent of significant technology. Besides the Hall of Fame, it also operates a museum in Alexandria, Virginia, sponsors educational programs, and a collegiate competition. As of 2020, 603 inventors have been inducted, mostly constituting historic persons from the past three centuries, but including about 100 living inductees. Nominees must hold a U.S. patent of significant contribution to the U.S. welfare, and which advances science and useful arts. The 2020 class included 22 inventors. History The National Inventors Hall of Fame was founded in 1973 on the initiative of H. Hume Mathews, then the chairman of the National Council of Patent Law Associations (now the National Council of Intellectual Property Law Associations). It was launched by Ed Sobey, who was also the first director. In 1974, it gained a ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Italian Chemical Society
The Italian Chemical Society ( it, Società Chimica Italiana) is the national association in Italy representing the chemical sciences. Its main aim is to promote and support the development of chemistry and scientific research, spreading the knowledge of chemistry and its applications in order to improve the welfare of the country, establishing and maintaining relations with organizations from other countries with similar purposes and promoting the study of this subject at school and university. History The Italian Chemical Society was formed in 1909 by the union of two existing societies, the Chemical Society of Rome, founded in 1902, and the Chemical Society of Milan, founded in 1895. The two original societies became sections of the new one and a third section was added in 1910, when the Chemical Society of Naples was incorporated. During the First World War the activity of the society experienced a marked decrease and the link among the three sections got was loosened, with the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society For Drug Research
A society is a group of individuals involved in persistent social interaction, or a large social group sharing the same spatial or social territory, typically subject to the same political authority and dominant cultural expectations. Societies are characterized by patterns of relationships (social relations) between individuals who share a distinctive culture and institutions; a given society may be described as the sum total of such relationships among its constituent of members. In the social sciences, a larger society often exhibits stratification or dominance patterns in subgroups. Societies construct patterns of behavior by deeming certain actions or concepts as acceptable or unacceptable. These patterns of behavior within a given society are known as societal norms. Societies, and their norms, undergo gradual and perpetual changes. Insofar as it is collaborative, a society can enable its members to benefit in ways that would otherwise be difficult on an individual bas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society Of Chemical Industry
The Society of Chemical Industry (SCI) is a learned society set up in 1881 "to further the application of chemistry and related sciences for the public benefit". Offices The society's headquarters is in Belgrave Square, London. There are semi-independent branches in the United States, Canada and Australia. Aims The society aims to accelerate the rate of scientific innovations being commercialised by industry to benefit society. It does this through promoting collaborations between scientists and industrialists, running technical and innovation conferences, building communities across academia and industry and publishing scientific content through its journals and digital platforms. It also promotes science education. History On 21 November 1879, Lancashire chemist John Hargreaves canvassed a meeting of chemists and managers in Widnes, St Helens and Runcorn to consider the formation of a chemical society. Modelled on the successful Tyne Chemical Society already operating in Newc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Chemical Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c) organization, 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 60 Scientific journal, scholarly journals including the prestigious ''Journal of the American Chemical Society'', as well as the weekly tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Royal Institute of Chemistry, the Faraday Society, and the Society for Analytical Chemistry with a new Royal Charter and the dual role of learned society and professional body. At its inception, the Society had a combined membership of 34,000 in the UK and a further 8,000 abroad. The headquarters of the Society are at Burlington House, Piccadilly, London. It also has offices in Thomas Graham House in Cambridge (named after Thomas Graham (chemist), Thomas Graham, the first president of the Chemical Society) where ''RSC Publishing'' is based. The Society has offices in the United States, on the campuses of The University of Pennsylvania and Drexel University, at the University City Science Center in Philadelphia, Pennsylvania, in both Beijing a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IUPAC
The International Union of Pure and Applied Chemistry (IUPAC ) is an international federation of National Adhering Organizations working for the advancement of the chemical sciences, especially by developing nomenclature and terminology. It is a member of the International Science Council (ISC). IUPAC is registered in Zürich, Switzerland, and the administrative office, known as the "IUPAC Secretariat", is in Research Triangle Park, North Carolina, United States. This administrative office is headed by IUPAC's executive director, currently Lynn Soby. IUPAC was established in 1919 as the successor of the International Congress of Applied Chemistry for the advancement of chemistry. Its members, the National Adhering Organizations, can be national chemistry societies, national academies of sciences, or other bodies representing chemists. There are fifty-four National Adhering Organizations and three Associate National Adhering Organizations. IUPAC's Inter-divisional Committee on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pitolisant
Pitolisant, sold under the brand name Wakix among others, is a medication for the treatment of excessive daytime sleepiness in adults with narcolepsy. It is a histamine 3 (H3) receptor antagonist/inverse agonist. It represents the first commercially available medication in its class. Pitolisant enhances the activity of histaminergic neurons in the brain that function to improve a person's wakefulness. The most common side effects include difficulty sleeping, nausea, and feeling worried. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Medical uses Pitolisant (Wakix) is used in adults for the treatment of excessive daytime sleepiness and narcolepsy. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Narcolepsy is a sleep problem that is characterized by an irresistible urge to sleep and disturbed nighttime sleep, while cataplexy refers to attacks of se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histaminergic
Histaminergic means "working on the histamine system", and histaminic means "related to histamine". A histaminergic agent (or drug) is a chemical which functions to directly modulate the histamine system in the body or brain. Examples include histamine receptor agonists and histamine receptor antagonists (or antihistamines). Subdivisions of histamine antagonists include H1 receptor antagonists, H2 receptor antagonists, and H3 receptor antagonists. See also * Adenosinergic * Adrenergic * Cannabinoidergic * Cholinergic * Dopaminergic * GABAergic * Glycinergic * Melatonergic * Monoaminergic * Opioidergic * Serotonergic Serotonergic () or serotoninergic () means "pertaining to or affecting serotonin". Serotonin is a neurotransmitter. A synapse is serotonergic if it uses serotonin as its neurotransmitter. A serotonergic neuron ''produces'' serotonin. A substance is ... References Neurochemistry Neurotransmitters {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
