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Burkholderia
''Burkholderia'' is a genus of Pseudomonadota whose pathogenic members include the ''Burkholderia cepacia'' complex, which attacks humans and ''Burkholderia mallei'', responsible for glanders, a disease that occurs mostly in horses and related animals; ''Burkholderia pseudomallei'', causative agent of melioidosis; and '' Burkholderia cepacia'', an important pathogen of pulmonary infections in people with cystic fibrosis (CF). ''Burkholderia'' species is also found marine environment. S.I. Paul et al. (2021) isolated and characterized ''Burkholderia cepacia'' from marine sponges of the Saint Martin's Island of the Bay of Bengal, Bangladesh. The ''Burkholderia'' (previously part of ''Pseudomonas'') genus name refers to a group of virtually ubiquitous Gram-negative, obligately aerobic, rod-shaped bacteria that are motile by means of single or multiple polar flagella, with the exception of ''Burkholderia mallei'', which is nonmotile. Members belonging to the genus do not produce s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burkholderia Pseudomallei
''Burkholderia pseudomallei'' (also known as ''Pseudomonas pseudomallei'') is a Gram-negative, bipolar, aerobic, motile rod-shaped bacterium. It is a soil-dwelling bacterium endemic in tropical and subtropical regions worldwide, particularly in Thailand and northern Australia. It was reported in 2008 that there had been an expansion of the affected regions due to significant natural disasters, and it could be found in Southern China, Hong Kong, and countries in America. ''B. pseudomallei'', amongst other pathogens, has been found in monkeys imported into the United States from Asia for laboratory use, posing a risk that the pathogen could be introduced into the country. Although it is mainly a soil-dwelling bacteria, a study performed by Apinya Pumpuang and others showed that ''Burkholderia pseudomallei'' survived in distilled water for 16 years, demonstrating that it is capable of living in water if a specific environment is provided. It is resistant to a variety of harsh condit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melioidosis
Melioidosis is an infectious disease caused by a gram-negative bacterium called ''Burkholderia pseudomallei''. Most people exposed to ''B. pseudomallei'' experience no symptoms; however, those who do experience symptoms have signs and symptoms that range from mild such as fever and skin changes, to severe with pneumonia, abscesses, and septic shock that could cause death. Approximately 10% of people with melioidosis develop symptoms that last longer than two months, termed "chronic melioidosis". Humans are infected with ''B. pseudomallei'' by contact with contaminated soil or water. The bacteria enter the body through wounds, inhalation, or ingestion. Person-to-person or animal-to-human transmission is extremely rare. The infection is constantly present in Southeast Asia particularly in northeast Thailand and northern Australia. In temperate countries such as Europe and the United States, melioidosis cases are usually imported from countries where melioidosis is endemic. The sign ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burkholderia Cepacia Complex
''Burkholderia cepacia'' complex (BCC), or simply ''Burkholderia cepacia'', is a group of catalase-producing, lactose-nonfermenting, Gram-negative bacteria composed of at least 20 different species, including ''B. cepacia'', '' B. multivorans'', '' B. cenocepacia'', '' B. vietnamiensis'', '' B. stabilis'', '' B. ambifaria'', '' B. dolosa'', '' B. anthina'', '' B. pyrrocinia'' and '' B. ubonensis''. ''B. cepacia'' is an opportunistic human pathogen that most often causes pneumonia in immunocompromised individuals with underlying lung disease (such as cystic fibrosis or chronic granulomatous disease). Patients with sickle-cell haemoglobinopathies are also at risk. The species complex also attacks young onion and tobacco plants, and displays a remarkable ability to digest oil. ''Burkholderia cepacia'' is also found in marine environments ( marine sponges) and some strains of ''Burkholderia cepacia'' can tolerate high salin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burkholderia Cepacia
''Burkholderia cepacia'' complex (BCC), or simply ''Burkholderia cepacia'', is a group of catalase-producing, lactose-nonfermenting, Gram-negative bacteria composed of at least 20 different species, including ''B. cepacia'', '' B. multivorans'', '' B. cenocepacia'', '' B. vietnamiensis'', '' B. stabilis'', '' B. ambifaria'', '' B. dolosa'', '' B. anthina'', '' B. pyrrocinia'' and '' B. ubonensis''. ''B. cepacia'' is an opportunistic human pathogen that most often causes pneumonia in immunocompromised individuals with underlying lung disease (such as cystic fibrosis or chronic granulomatous disease). Patients with sickle-cell haemoglobinopathies are also at risk. The species complex also attacks young onion and tobacco plants, and displays a remarkable ability to digest oil. ''Burkholderia cepacia'' is also found in marine environments ( marine sponges) and some strains of ''Burkholderia cepacia'' can tolerate high salinity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burkholderia Mallei
''Burkholderia mallei'' is a Gram-negative, bipolar, aerobic bacterium, a human and animal pathogen of genus ''Burkholderia'' causing glanders; the Latin name of this disease (''malleus'') gave its name to the species causing it. It is closely related to '' B. pseudomallei,'' and by multilocus sequence typing it is a subspecies of ''B. pseudomallei.'' ''B. mallei'' evolved from ''B. pseudomallei'' by selective reduction and deletions from the ''B. pseudomallei'' genome. Unlike ''B. pseudomallei'' and other genus members, ''B. mallei'' is nonmotile; its shape is coccobacillary measuring some 1.5–3.0 μm in length and 0.5–1.0 μm in diameter with rounded ends. Discovery and early history Wilhelm Schütz and Friedrich Löffler first isolated ''B. mallei'' in 1882. It was isolated from an infected liver and spleen of a horse. This bacterium is also one of the first to be identified containing a type VI secretion system which is important for it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudomonas
''Pseudomonas'' is a genus of Gram-negative, Gammaproteobacteria, belonging to the family Pseudomonadaceae and containing 191 described species. The members of the genus demonstrate a great deal of metabolic diversity and consequently are able to colonize a wide range of niches. Their ease of culture ''in vitro'' and availability of an increasing number of ''Pseudomonas'' strain genome sequences has made the genus an excellent focus for scientific research; the best studied species include ''P. aeruginosa'' in its role as an opportunistic human pathogen, the plant pathogen '' P. syringae'', the soil bacterium '' P. putida'', and the plant growth-promoting ''P. fluorescens, P. lini, P. migulae'', and ''P. graminis''. Because of their widespread occurrence in water and plant seeds such as dicots, the pseudomonads were observed early in the history of microbiology. The generic name ''Pseudomonas'' created for these organisms was defined in rather vague terms by Walter Migula i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cystic Fibrosis
Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. Other signs and symptoms may include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in most males. Different people may have different degrees of symptoms. Cystic fibrosis is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Those with a single working copy are carriers and otherwise mostly healthy. CFTR is involved in the production of sweat, digestive fluids, and mucus. When the CFTR is not functional, secretions which are usually thin instead become thick. The condition is diagnosed by a sweat test and genetic testing. Screening of infants at bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paraburkholderia
''Paraburkholderia'' is a genus of Pseudomonadota that are gram negative, slightly curved rods that are motile by means of flagella. They have been reported to colonize endophytic tissues of hybrid spruce (Picea glauca x engelmannii) and lodgepole pine with a strong potential to perform biological nitrogen fixation and plant growth promotion. Unlike ''Burkholderia'' species, ''Paraburkholderia'' members are not commonly associated with human infection. ''Paraburkholderia'' members form a monophyletic clade within the Burkholderiaceae family, which is what prompted their distinction as a genus independent from ''Burkholderia'' species, in combination with the finding of robust conserved signature indels which are unique to ''Paraburkholderia'' species, and are lacking in members of the genus ''Burkholderia''. These CSIs distinguish the genus from all other bacteria. Additionally, the CSIs that were found to be shared by ''Burkholderia'' species are absent in ''Paraburkholderia'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glanders
Glanders is a contagious zoonotic infectious disease that occurs primarily in horses, mules, and donkeys. It can be contracted by other animals, such as dogs, cats, pigs, goats, and humans. It is caused by infection with the bacterium ''Burkholderia mallei''. Glanders is endemic in Africa, Asia, the Middle East, and Central and South America. It has been eradicated from North America, Australia, and most of Europe through surveillance and destruction of affected animals, and import restrictions. Glanders has not been reported in the United States since 1945, except in 2000, when an American lab researcher had an accidental exposure in the lab. It is a notifiable disease in the UK, although it has not been reported there since 1928. The term is from Middle English ' or Old French ', both meaning glands. Other terms include la, malleus, es, muermo, german: Rotz and no, snive. Presentation Signs of glanders include the formation of nodular lesions in the lungs and ulceration ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Warfare
Biological warfare, also known as germ warfare, is the use of biological toxins or infectious agents such as bacteria, viruses, insects, and fungi with the intent to kill, harm or incapacitate humans, animals or plants as an act of war. Biological weapons (often termed "bio-weapons", "biological threat agents", or "bio-agents") are living organisms or replicating entities ( ''i.e.'' viruses, which are not universally considered "alive"). Entomological (insect) warfare is a subtype of biological warfare. Offensive biological warfare is prohibited under customary international humanitarian law and several international treaties. In particular, the 1972 Biological Weapons Convention (BWC) bans the development, production, acquisition, transfer, stockpiling and use of biological weapons. Therefore, the use of biological agents in armed conflict is a war crime. In contrast, defensive biological research for prophylactic, protective or other peaceful purposes is not proh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-hemB RNA Motif
The anti-hemB RNA motif is a conserved RNA structure that was found in all known bacteria in the genus ''Burkholderia'', and in a variety of other betaproteobacteria. The anti-hemB RNA motif consists primarily of two stem-loops, followed by a predicted rho-independent transcription termination stem-loop. As anti-hemB RNAs are generally not located in a 5' UTR, the RNAs are presumed to be non-coding RNAs. The terminator stem-loop implies that anti-hemB RNAs are transcribed as independent molecules. The name "anti-hemB" is to distinguish the motif from its reverse complement, which was called the "hemB" motif, a motif that is often in the apparent 5' UTRs of ''hemB'' genes. It was considered ambiguous as to which of these orientations is correct, as both directions exhibit covariation (see secondary structure prediction), and both fold into plausible RNA structures. However, the anti-hemB was judged the more likely orientation, because it had fewer A-C base pair A base pair ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Granulomatous Disease
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. This leads to the formation of granulomas in many organs. CGD affects about 1 in 200,000 people in the United States, with about 20 new cases diagnosed each year. This condition was first discovered in 1950 in a series of 4 boys from Minnesota, and in 1957 it was named "a fatal granulomatosus of childhood" in a publication describing their disease. The underlying cellular mechanism that causes chronic granulomatous disease was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the disease. Bernard Babior made key contributions in linking the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
