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Brockham Park
Brockham is a village and civil parish in the Mole Valley district of Surrey, England. It is approximately east of Dorking and west of Reigate. The village lies south of Box Hill, with the River Mole flowing west through the village. At the 2011 census, it had a population of 2,868.Key Statistics; Quick Statistics: Population Density '''' Retrieved 21 November 2013 Name Brockham, originally 'Brook-ham' (bend in a brook) is ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mole Valley
Mole Valley is a local government district in Surrey, England. Its council is based in Dorking. The other town in the district is Leatherhead. The largest villages are Ashtead, Fetcham and Great Bookham, in the northern third of the district. Most of the district is on the escarpments of or adjoins the Surrey Hills AONB (the North Downs and Greensand Ridge including locally Leith Hill, Polesden Lacey, Box Hill and Denbies Wine Estate, the largest vineyard in the country and several golf courses) The North Downs are followed or parallelled by the Pilgrims' Way. There are stations on the London–Worthing and Reading–Gatwick Airport railways, and in the northern third, a commuter stopping-service pattern line, London–Guildford (via Epsom) line. The A24 road and the M25 motorway are the main thoroughfares and relative to London the incidence of car ownership is high. The area hosts hill-focussed sub-laps of the London–Surrey Classic cycling tour each year. Towns * Dor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chancellor Of The Exchequer
The chancellor of the Exchequer, often abbreviated to chancellor, is a senior minister of the Crown within the Government of the United Kingdom, and head of His Majesty's Treasury. As one of the four Great Offices of State, the Chancellor is a high-ranking member of the British Cabinet. Responsible for all economic and financial matters, the role is equivalent to that of a finance minister in other countries. The chancellor is now always Second Lord of the Treasury as one of at least six lords commissioners of the Treasury, responsible for executing the office of the Treasurer of the Exchequer the others are the prime minister and Commons government whips. In the 18th and early 19th centuries, it was common for the prime minister also to serve as Chancellor of the Exchequer if he sat in the Commons; the last Chancellor who was simultaneously prime minister and Chancellor of the Exchequer was Stanley Baldwin in 1923. Formerly, in cases when the chancellorship was vacant, the L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surrey County Council
Surrey County Council is the county council administering certain services in the non-metropolitan county of Surrey in England. The council is composed of 81 elected councillors, and in all but one election since 1965 the Conservative Party has held the majority. The leader of the council is Tim Oliver. History Formation Surrey County Council was created in 1889 by the Local Government Act 1888, which established the county council local government system in England and Wales. It replaced the Surrey Quarter Sessions for local government functions in the administrative county of Surrey. The council was originally headquartered in Newington where the quarter sessions court had been located. However it moved to County Hall, Kingston upon Thames in 1893 as Newington and the part of Surrey that had been in the Metropolitan Board of Works district had become part of the County of London in 1889. Kingston upon Thames became part of Greater London in 1965, but the headquarters remai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRSA
Methicillin-resistant ''Staphylococcus aureus'' (MRSA) is a group of Gram-positive bacteria that are genetically distinct from other strains of ''Staphylococcus aureus''. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths attributable to antimicrobial resistance in 2019. MRSA is any strain of ''S. aureus'' that has developed (through natural selection) or acquired (through horizontal gene transfer) a multiple drug resistance to beta-lactam antibiotics. Beta-lactam (β-lactam) antibiotics are a broad-spectrum group that include some penams (penicillin derivatives such as methicillin and oxacillin) and cephems such as the cephalosporins. Strains unable to resist these antibiotics are classified as methicillin-susceptible ''S. aureus'', or MSSA. MRSA is common in hospitals, prisons, and nursing homes, where people with open wounds, invasive devices such as catheters, and weakened immune systems are at greater risk of hea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methicillin
Methicillin (USAN), also known as meticillin (INN), is a narrow-spectrum β-lactam antibiotic of the penicillin class. Methicillin was discovered in 1960. Medical uses Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a higher frequency of interstitial nephritis, an otherwise-rare adverse effect of penicillins. However, selection of methicillin depended on the outcome of susceptibility testing of the sampled infection, and since it is no longer produced, it is also not routinely tested for any more. It also served a purpose in the laboratory to determine the antibiotic sensitivity of ''Staphylococcus aureus'' to other penicillins facing β-lactam resistance; this role has now been passed on to other penicillins, namely ''cloxacillin'', as well as genetic testing for the presence of ''mecA'' gene by '' PCR''. Spectrum of activity At one time, methicillin was used to tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
6-APA
6-APA ((+)-6-aminopenicillanic acid) is a chemical compound used as an intermediate in the synthesis of β-lactam antibiotics. The major commercial source of 6-APA is still natural penicillin G: the semi-synthetic penicillins derived from 6-APA are also referred to as penicillins and are considered part of the penicillin family of antibiotics. In 1958, Beecham scientists from Brockham Park, Surrey, found a way to obtain 6-APA from penicillin. Other β-lactam antibiotics could then be synthesized by attaching various side-chains to the nucleus.F.P. Doyle, J.H.C. Nayler, G.N. Rolinson ''US Patent 2,941,995'', filed July 22, 1958, granted June 21, 1960. Recovery of solid 6-aminopenicillanic acid. The reason why this was achieved so many years after the commercial development of penicillin by Howard Florey and Ernst Chain lies in the fact that penicillin itself is very susceptible to hydrolysis Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brockham Park
Brockham is a village and civil parish in the Mole Valley district of Surrey, England. It is approximately east of Dorking and west of Reigate. The village lies south of Box Hill, with the River Mole flowing west through the village. At the 2011 census, it had a population of 2,868.Key Statistics; Quick Statistics: Population Density '''' Retrieved 21 November 2013 Name Brockham, originally 'Brook-ham' (bend in a brook) is ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GlaxoSmithKline
GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tenth largest pharmaceutical company and #294 on the 2022 ''Fortune'' Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck. The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. , it had a market capitalisation of £70 billion, the eighth largest on the London Stock Exchange. It has a secondary listing on the New York Stock Exchange. The company developed the first malaria vaccine, RTS,S, which it said in 2014 it would make available for five percent above cost. Legacy products developed at GSK include several listed in the World Health Organization's List of Essential Medicines, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beecham Group
The Beecham Group plc was a British pharmaceutical company. It was once a constituent of the FTSE 100 Index. Beecham, after having merged with American pharmaceutical company SmithKline Beckman to become SmithKline Beecham, merged with Glaxo Wellcome to become GlaxoSmithKline (GSK). GSK still uses the Beechams brand name in the UK for its over-the-counter cold and flu relief products. Early history Beecham began as the family business of Thomas Beecham (1820–1907), a chemist. (Beecham would become the grandfather of music conductor Thomas Beecham, 1879–1961). As a boy, Beecham worked as a shepherd, selling herbal remedies as a sideline. He later became a travelling salesman or peddler full time. His first product was Beecham's Pills, a laxative, in 1842. Subsequent success enabled him to open a shop in Wigan in 1847. Beecham opened its first factory in 1849 in St Helens, Lancashire, for the rapid production of medicines. Under his son, Sir Joseph Beecham, 1st Baronet (184 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chalk
Chalk is a soft, white, porous, sedimentary carbonate rock. It is a form of limestone composed of the mineral calcite and originally formed deep under the sea by the compression of microscopic plankton that had settled to the sea floor. Chalk is common throughout Western Europe, where deposits underlie parts of France, and steep cliffs are often seen where they meet the sea in places such as the Dover cliffs on the Kent coast of the English Channel. Chalk is mined for use in industry, such as for quicklime, bricks and builder's putty, and in agriculture, for raising pH in soils with high acidity. It is also used for " blackboard chalk" for writing and drawing on various types of surfaces, although these can also be manufactured from other carbonate-based minerals, or gypsum. Description Chalk is a fine-textured, earthy type of limestone distinguished by its light color, softness, and high porosity. It is composed mostly of tiny fragments of the calcite shells or skeletons ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guy Fawkes Night
Guy Fawkes Night, also known as Guy Fawkes Day, Bonfire Night and Fireworks Night, is an annual commemoration observed on 5 November, primarily in Great Britain, involving bonfires and fireworks displays. Its history begins with the events of 5 November 1605 O.S., when Guy Fawkes, a member of the Gunpowder Plot, was arrested while guarding explosives the plotters had placed beneath the House of Lords. The Catholic plotters had intended to assassinate Protestant king James I and his parliament. Celebrating that the king had survived, people lit bonfires around London; and months later, the Observance of 5th November Act mandated an annual public day of thanksgiving for the plot's failure. Within a few decades Gunpowder Treason Day, as it was known, became the predominant English state commemoration. As it carried strong Protestant religious overtones it also became a focus for anti-Catholic sentiment. Puritans delivered sermons regarding the perceived dangers of p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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