Borrelia Miyamotoi
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Borrelia Miyamotoi
''Borrelia miyamotoi'' is a bacterium of the spirochete phylum in the genus ''Borrelia''. A zoonotic organism, ''B. miyamotoi'' can infect humans through the bite of several species of hard-shell ''Ixodes'' ticks, the same kind of ticks that spread ''B. burgdorferi'', the causative bacterium of Lyme disease. Ixodes ticks are also the primary vector in the spread of babesiosis and anaplasmosis. ''B. miyamotoi'' causes ''Borrelia miyamotoi'' disease (BMD) in humans. BMD is a relapsing fever illness that has been reported across the world, often in the same geographic areas where Lyme disease is endemic. Treatment currently follows that of Lyme disease. Microbiology History and morphology ''B. miyamotoi'' was discovered in 1995 when it was isolated from a population of '' Ixodes persulcates'' ticks on the Japanese island of Hokkaido. The organism was named for Kenji Miyamoto, who initially discovered ''Borrellia'' spirochetes in Japan. It was first detected in the United State ...
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Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationsh ...
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Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ...
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Bank Vole
The bank vole (''Myodes glareolus'') is a small vole with red-brown fur and some grey patches, with a tail about half as long as its body. A rodent, it lives in woodland areas and is around in length. The bank vole is found in much of Europe and in northwestern Asia. It is native to Great Britain but not to Ireland, where it has been accidentally introduced, and has now colonised much of the south and southwest. The bank vole lives in woodland, hedgerows and other dense vegetation such as bracken and bramble. Its underground chamber is lined with moss, feathers and vegetable fibre and contains a store of food. It can live for eighteen months to two years in the wild and over 42 months in captivity and is mostly herbivorous, eating buds, bark, seeds, nuts, leaves and fruits and occasionally insects and other small invertebrates. It readily climbs into scrub and low branches of trees although it is not as versatile as a mouse. It breeds in shallow burrows, the female rearing about ...
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Apodemus
''Apodemus'' is a genus of Muridae (true mice and rats). The name is unrelated to that of the '' Mus'' genus, instead being derived from the Greek ἀπό-δημος (literally ''away from home''). Taxonomy Related to the Ryūkyū spiny rats (''Tokudaia'') and the prehistoric ''Rhagamys'' – and far more distantly to '' Mus'' and '' Malacomys'' – it includes these species: ''Apodemus sensu stricto'' * Striped field mouse, ''A. agrarius'' * Chevrier's field mouse, ''A. chevrieri'' * Small Japanese field mouse, ''A. argenteus'' ''Alsomys'' * South China field mouse, ''A. draco'' * Himalayan field mouse, ''A. gurkha'' * Sichuan field mouse, ''A. latronum'' * Korean field mouse, ''A. peninsulae'' * Taiwan field mouse, ''A. semotus'' * Large Japanese field mouse, ''A. speciosus'' ''Sylvaemus'' * Alpine field mouse, ''A. alpicola'' * Yellow-necked mouse, ''A. flavicollis'' – includes ''A. arianus'' * Caucasus field mouse, ''A. hyrcanicus'' * Ward's field mouse ...
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Vole
Voles are small rodents that are relatives of lemmings and hamsters, but with a stouter body; a longer, hairy tail; a slightly rounder head; smaller eyes and ears; and differently formed molars (high-crowned with angular cusps instead of low-crowned with rounded cusps). They are sometimes known as meadow mice or field mice in North America. Vole species form the subfamily Arvicolinae with the lemmings and the muskrats. There are approximately 155 different vole species. Description Voles are small rodents that grow to , depending on the species. Females can have five to ten litters per year, though with an average lifespan of three months and requiring one month to adulthood, two litters is the norm. Gestation lasts for three weeks and the young voles reach sexual maturity in a month. As a result of this biological exponential growth, vole populations can grow very large within a short time. A mating pair can produce a hundred more voles in a year. Voles outwardly resemble s ...
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Mouse
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus''). Mice are also popular as pets. In some places, certain kinds of field mice are locally common. They are known to invade homes for food and shelter. Mice are typically distinguished from rats by their size. Generally, when a muroid rodent is discovered, its common name includes the term ''mouse'' if it is smaller, or ''rat'' if it is larger. The common terms ''rat'' and ''mouse'' are not taxonomically specific. Typical mice are classified in the genus '' Mus'', but the term ''mouse'' is not confined to members of ''Mus'' and can also apply to species from other genera such as the deer mouse, ''Peromyscus''. Domestic mice sold as pets often differ substantially in size from the common house mouse. This is attributable to breeding a ...
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Innate Immune System
The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).. The major functions of the innate immune system are to: * recruit immune cells to infection sites by producing chemical factors, including chemical mediators called cytokines * activate the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells * identify and remove foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells * activate the adaptive immune system through antigen presentation * act as a physical and chemical barrier to infectious agents; via physical measures such as skin and chemical measures such a ...
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Complement System
The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system. The complement system consists of a number of small proteins that are synthesized by the liver, and circulate in the blood as inactive precursors. When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end result of this ''complement activation'' or ''complement fixation'' cascade is stimulation of phagocytes to clear foreign and damaged material ...
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Antigenic Variation
Antigenic variation or antigenic alteration refers to the mechanism by which an infectious agent such as a protozoan, bacterium or virus alters the proteins or carbohydrates on its surface and thus avoids a host immune response, making it one of the mechanisms of antigenic escape. It is related to phase variation. Antigenic variation not only enables the pathogen to avoid the immune response in its current host, but also allows re-infection of previously infected hosts. Immunity to re-infection is based on recognition of the antigens carried by the pathogen, which are "remembered" by the acquired immune response. If the pathogen's dominant antigen can be altered, the pathogen can then evade the host's acquired immune system. Antigenic variation can occur by altering a variety of surface molecules including proteins and carbohydrates. Antigenic variation can result from gene conversion, site-specific DNA inversions, hypermutation, or recombination of sequence cassettes. The result ...
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Transovarial Transmission
Transovarial or transovarian transmission (transmission from parent to offspring via the ovaries) occurs in certain arthropod vectors as they transmit pathogens from parent to offspring. This process, used by a wide variety of parasites, is also known as vertical transmission. For example, ''Rickettsia rickettsii'', carried within ticks, is passed on from parent to offspring tick by transovarial transmission. This is in contrast to parasites such as ''Rickettsia prowazekii,'' which are not passed on by transovarian transmission due to killing the vector that carries it (in this case, the human louse). Other examples of parasites that use this mechanism of transmission include the aedes mosquito vector of the yellow fever virus and in phlebotomine sandflies that transmit pappataci fever. Richard Dawkins in "The Extended Phenotype" notes that "bacterial endosymbionts of insects which are transmitted transovarially" share an interest in the "success of their host's gametes.....as we ...
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Clade
A clade (), also known as a monophyletic group or natural group, is a group of organisms that are monophyletic – that is, composed of a common ancestor and all its lineal descendants – on a phylogenetic tree. Rather than the English term, the equivalent Latin term ''cladus'' (plural ''cladi'') is often used in taxonomical literature. The common ancestor may be an individual, a population, or a species (extinct or extant). Clades are nested, one in another, as each branch in turn splits into smaller branches. These splits reflect evolutionary history as populations diverged and evolved independently. Clades are termed monophyletic (Greek: "one clan") groups. Over the last few decades, the cladistic approach has revolutionized biological classification and revealed surprising evolutionary relationships among organisms. Increasingly, taxonomists try to avoid naming taxa that are not clades; that is, taxa that are not monophyletic. Some of the relationships between organisms ...
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Genotype
The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a specific gene depends on the number of copies of each chromosome found in that species, also referred to as ploidy. In diploid species like humans, two full sets of chromosomes are present, meaning each individual has two alleles for any given gene. If both alleles are the same, the genotype is referred to as homozygous. If the alleles are different, the genotype is referred to as heterozygous. Genotype contributes to phenotype, the observable traits and characteristics in an individual or organism. The degree to which genotype affects phenotype depends on the trait. For example, the petal color in a pea plant is exclusively determined by genotype. The petals can be purple or white depending on the alleles present in the pea plant. Howev ...
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