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Body Surface Area
In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body. For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index, such as chemotherapy. Typically there is a 4–10 fold variation in drug clearance between individuals due to differing the activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and underdosing (and increased risk of disease recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Uses Examples of uses of the BSA: * Renal clearan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms ( palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). The development of therapies with specific molecular or genetic targets, wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Organisation For Research And Treatment Of Cancer
The European Organisation for Research and Treatment of Cancer (EORTC) is a unique pan-European non-profit clinical cancer research organisation established in 1962 operating as an international association under Belgium law. It develops, conducts, coordinates and stimulates high-quality translational and clinical trial research to improve the survival and quality of life of cancer patients. This is achieved through the development of new drugs and other innovative approaches, and the testing of more effective therapeutic strategies, using currently approved drugs, surgery and/or radiotherapy in clinical trials conducted under the auspices of a vast network of clinical cancer researchers supported by 220 staff members based in Brussels. The EORTC has the expertise to conduct large and complex trials especially specific populations such as the older patient and rare tumours. Mission, achievements, and network The EORTC's mission is to increase people's survival and quality of li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hanan Costeff
Hanan Costeff (1926–2005) was a pediatric neurologist, researcher, and teacher. Costeff was born in Sep. 14, 1926 to Dr. Harry and Stella Costeff in Peoria, Illinois. His father, Harry Gedalya came to the USA from a Jewish village named Kabaschei in the Russian Empire, served in World War I and later studied to be a pharmacist, and then a medical doctor. He pioneered the use of insulin shock therapy for Schizophrenia, and founded a private hospital in Peoria. Hanan grew up in Peoria, served in the navy during the latter part of World War II, and trained as a radio technician. Upon being released, he used GI bill funds to study medicine at the University of Illinois at Urbana–Champaign, graduating in 1951. He met and married Ramona Doctor in Chicago in 1951. In 1950, while still a student he visited the newly founded State of Israel, traveled, met some family and managed a children's ward at the then new immigrant camp of Rosh Ha'Ayin. Upon completion of his residency, and th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicina Internacia Revuo
''Medicina Internacia Revuo'' (originally ''Internacia Medicina Revuo'' or, in English, the ''International Medical Review'') is the official organ of Universala Medicina Esperanto Asocio, an organization that gathers physicians, pharmacists, and other medical professionals who have a working knowledge of Esperanto. The twice-yearly journal publishes articles that have undergone peer review and that are written in various languages, including English and Polish; abstracts are provided in English and Esperanto. The journal publishes broadly within the medical sciences, has an internationally renowned board of editors, and is included in the Index Copernicus database. The journal is available gold open access, but no author fees are charged. History As early as the Third Congress on Esperanto, held in London in 1907, there was a call from members of the medical professions to establish a medical journal in Esperanto. Indeed, a letter to the British medical journal The Lancet praised ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N Engl J Med
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. History In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' purchased the weekly ''Intelligencer'' for $600 in 18 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Body Mass Index
Body mass index (BMI) is a value derived from the mass (weight) and height of a person. The BMI is defined as the body mass divided by the square of the body height, and is expressed in units of kg/m2, resulting from mass in kilograms and height in metres. The BMI may be determined using a table or chart which displays BMI as a function of mass and height using contour lines or colours for different BMI categories, and which may use other units of measurement (converted to metric units for the calculation). The BMI is a convenient rule of thumb used to broadly categorize a person as ''underweight'', ''normal weight'', ''overweight'', or ''obese'' based on tissue mass (muscle, fat, and bone) and height. Major adult BMI classifications are underweight (under 18.5 kg/m2), normal weight (18.5 to 24.9), overweight (25 to 29.9), and obese (30 or more). When used to predict an individual's health, rather than as a statistical measurement for groups, the BMI has limitations ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Centimeter
330px, Different lengths as in respect to the Electromagnetic spectrum, measured by the Metre and its deriveds scales. The Microwave are in-between 1 meter to 1 millimeter. A centimetre (international spelling) or centimeter (American spelling) (SI symbol cm) is a Units of measurement, unit of length in the International System of Units (SI), equal to one hundredth of a metre, ''centi'' being the SI prefix for a factor of . The centimetre was the base unit of length in the now deprecated centimetre–gram–second (CGS) system of units. Though for many physical quantities, SI prefixes for factors of 103—like ''milli-'' and ''kilo-''—are often preferred by technicians, the centimetre remains a practical unit of length for many everyday measurements. A centimetre is approximately the width of the fingernail of an average adult person. Equivalence to other units of length : One millilitre is defined as one cubic centimetre, under the SI system of units. Other uses In ad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kilogram
The kilogram (also kilogramme) is the unit of mass in the International System of Units (SI), having the unit symbol kg. It is a widely used measure in science, engineering and commerce worldwide, and is often simply called a kilo colloquially. It means 'one thousand grams'. The kilogram is defined in terms of the second and the metre, both of which are based on fundamental physical constants. This allows a properly equipped metrology laboratory to calibrate a mass measurement instrument such as a Kibble balance as the primary standard to determine an exact kilogram mass. The kilogram was originally defined in 1795 as the mass of one litre of water. The current definition of a kilogram agrees with this original definition to within 30 parts per million. In 1799, the platinum ''Kilogramme des Archives'' replaced it as the standard of mass. In 1889, a cylinder of platinum-iridium, the International Prototype of the Kilogram (IPK), became the standard of the unit of mass for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meter
The metre (British spelling) or meter (American spelling; see spelling differences) (from the French unit , from the Greek noun , "measure"), symbol m, is the primary unit of length in the International System of Units (SI), though its prefixed forms are also used relatively frequently. The metre was originally defined in 1793 as one ten-millionth of the distance from the equator to the North Pole along a great circle, so the Earth's circumference is approximately km. In 1799, the metre was redefined in terms of a prototype metre bar (the actual bar used was changed in 1889). In 1960, the metre was redefined in terms of a certain number of wavelengths of a certain emission line of krypton-86. The current definition was adopted in 1983 and modified slightly in 2002 to clarify that the metre is a measure of proper length. From 1983 until 2019, the metre was formally defined as the length of the path travelled by light in a vacuum in of a second. After the 2019 redefiniti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
