|
Biolex
Biolex Therapeutics was a biotechnology firm in the Research Triangle of North Carolina which was founded in 1997 and raised $190 million from investors. It filed for Chapter 7 bankruptcy on July 5, 2012. The company focused on expression of difficult-to-synthesize recombinant proteins in its LEX platform, which used ''Lemna'', a duckweed. The duckweeds are a family of small aquatic plants that can be grown in sterile culture. Biolex developed recombinant DNA technology for efficiently producing pharmaceutical proteins in Lemna. Therapeutic glycosylated proteins, including monoclonal antibodies and interferon (IFN-alpha2b) have been produced using the LEX platform. Biolex acquired Epicyte Pharmaceutical Inc. on May 6, 2004, and acquired the LemnaGene SA of Lyon, France in 2005. Biolex was a privately held company, originally backed by Quaker BioVentures, The Trelys Funds, and Polaris Venture Partners. The term "plantibody" is trademarked by Biolex. In May 2012 Biolex ann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biolex Logo
Biolex Therapeutics was a biotechnology firm in the Research Triangle of North Carolina which was founded in 1997 and raised $190 million from investors. It filed for Chapter 7 bankruptcy on July 5, 2012. The company focused on expression of difficult-to-synthesize recombinant proteins in its LEX platform, which used ''Lemna'', a duckweed. The duckweeds are a family of small aquatic plants that can be grown in sterile culture. Biolex developed recombinant DNA technology for efficiently producing pharmaceutical proteins in Lemna. Therapeutic glycosylated proteins, including monoclonal antibodies and interferon (IFN-alpha2b) have been produced using the LEX platform. Biolex acquired Epicyte Pharmaceutical Inc. on May 6, 2004, and acquired the LemnaGene SA of Lyon, France in 2005. Biolex was a privately held company, originally backed by Quaker BioVentures, The Trelys Funds, and Polaris Venture Partners. The term "plantibody" is trademarked by Biolex. In May 2012 Biolex a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthon (company)
Synthon is a Dutch multinational that produces generic human drugs. The company was founded in 1991 by Jacques Lemmens and Huub Sanders, two organic chemists of the Radboud University Nijmegen. Synthon is active in the Netherlands, the Czech Republic, Spain, the United States, Argentina, Chile, Russia, Mexico and South Korea with about 1,500 employees. The company is headquartered in Nijmegen. Medications made by Synthon include: * Simvastatin (A statin) * Tamsulosin (An alpha blocker for the symptomatic treatment of benign prostatic hyperplasia) * Paroxetine (An antidepressant) * Fluvoxamine (An antidepressant) The products are marketed by partners of the company. The name Synthon is not mentioned on the packaging. History In 2007 the company started developing biopharmaceuticals. In May 2012 Synthon announced that it bought the Biolex LEX System for manufacturing biopharmaceuticals in Lemna. The sale also included two preclinical biologics made with the LEX Syst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lemna
''Lemna'' is a genus of free-floating aquatic plants referred to by the common name "Lemnoideae, duckweed". They are morphologically divergent members of the arum family Araceae. These rapidly growing plants have found uses as a Model organism, model system for studies in community (ecology), community ecology, basic plant biology, ecotoxicology, and production of biopharmaceuticals, and as a source of animal feeds for agriculture and aquaculture. Currently, 14 species of ''Lemna'' are recognised. Taxonomy These duckweeds were previously placed in a separate flowering plant family, the Lemnaceae, but they are now considered to be members of the Araceae. Description ''Lemna'' species grow as simple free-floating Thallus (tissue), thalli on or just beneath the water surface. Most are small, not exceeding 5 mm in length, except ''Lemna trisulca'', which is elongated and has a branched structure. ''Lemna'' thalli have a single root, which distinguishes this genus from the rela ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plantibody
Passive immunization is a medical strategy long employed to provide temporary protection against pathogens. Early implementations involved recovering ostensibly cell-free plasma from the blood of human survivors or from non-human animals deliberately exposed to a specific pathogen or toxin. These approaches resulted in crude purifications of plasma-soluble proteins including antibodies. Antibodies (also known as an immunoglobulins) are complex proteins produced by vertebrates that recognize antigens (or molecular patterns) on pathogens and some dangerous compounds in order to alert the Adaptive immune system that there are pathogens within the body. A plantibody is an antibody that is produced by plants that have been genetically engineered with animal DNA encoding a specific human antibody known to neutralize a particular pathogen or toxin. The transgenic plants produce antibodies that are similar to their human counterparts, and following purification, plantibodies can be adminis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Triangle Park
Research Triangle Park (RTP) is the largest research park in the United States, occupying in North Carolina and hosting more than 300 companies and 65,000 workers. The facility is named for its location relative to the three surrounding cities of Raleigh, Durham, and Chapel Hill, or more properly, for the three major research universities in them: North Carolina State University, Duke University and University of North Carolina at Chapel Hill respectively. The Research Triangle region of North Carolina received its name as an extension of the name of the park. Aside from the three anchor cities, the park is also bounded by the communities of Morrisville and Cary. Approximately one fourth of the Park's territory lies in Wake County, but the majority of its land is in Durham County. Overview Research Triangle Park is one of the most prominent high-tech research and development parks in the United States. It was created in 1959 by state and local governments, nearby universities ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CD20
B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. In humans CD20 is encoded by the ''MS4A1'' gene. This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants that encode the same protein. Function The protein has no known natural Ligand (biochemistry), ligand and its function is to enable optimal B-cell immune response, specifically against T-i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Companies Disestablished In 2012
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are classified in multiple ways. One of the key divisions is by level of control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the order of a physician, physician assistant, or qualified nurse) from over-the-counter drugs (those that consumers can order for themselves). Another key distinction is between traditional small molecule drugs, usually derived from chemical synthesis, and biopharmaceuticals, which include recombinant proteins, vaccines, blood products used therapeutically (such as IVIG), gene therapy, monoclonal antibodies and cell therapy (for instance, stem cell therapi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology Companies Disestablished In 2012
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology Companies Established In 1997
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Sciences Industry
Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energy transformation, and reproduction. Various forms of life exist, such as plants, animals, fungi, protists, archaea, and bacteria. Biology is the science that studies life. The gene is the unit of heredity, whereas the cell is the structural and functional unit of life. There are two kinds of cells, prokaryotic and eukaryotic, both of which consist of cytoplasm enclosed within a membrane and contain many biomolecules such as proteins and nucleic acids. Cells reproduce through a process of cell division, in which the parent cell divides into two or more daughter cells and passes its genes onto a new generation, sometimes producing genetic variation. Organisms, or the individual entities of life, are generally thought to be open systems that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Defunct Pharmaceutical Companies Of The United States
{{Disambiguation ...
Defunct (no longer in use or active) may refer to: * ''Defunct'' (video game), 2014 * Zombie process or defunct process, in Unix-like operating systems See also * * :Former entities * End-of-life product * Obsolescence Obsolescence is the state of being which occurs when an object, service, or practice is no longer maintained or required even though it may still be in good working order. It usually happens when something that is more efficient or less risky r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology Companies Of The United States
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
