Bioinformatics Resource Centers
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Bioinformatics Resource Centers
The Bioinformatics Resource Centers (BRCs) are a group of five Internet-based research centers established in 2004 and funded by NIAID (the National Institute of Allergy and Infectious Diseases.)Overview, Bioinformatics Resource Centers
, National Institute of Allergy and Infectious Diseases (NIAID), January 10, 2008.
The BRCs were formed in response to the threats posed by emerging and re-emerging s, particularly (CDC) C ...
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Internet
The Internet (or internet) is the global system of interconnected computer networks that uses the Internet protocol suite (TCP/IP) to communicate between networks and devices. It is a '' network of networks'' that consists of private, public, academic, business, and government networks of local to global scope, linked by a broad array of electronic, wireless, and optical networking technologies. The Internet carries a vast range of information resources and services, such as the inter-linked hypertext documents and applications of the World Wide Web (WWW), electronic mail, telephony, and file sharing. The origins of the Internet date back to the development of packet switching and research commissioned by the United States Department of Defense in the 1960s to enable time-sharing of computers. The primary precursor network, the ARPANET, initially served as a backbone for interconnection of regional academic and military networks in the 1970s to enable resource shari ...
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Canada
Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by total area. Its southern and western border with the United States, stretching , is the world's longest binational land border. Canada's capital is Ottawa, and its three largest metropolitan areas are Toronto, Montreal, and Vancouver. Indigenous peoples have continuously inhabited what is now Canada for thousands of years. Beginning in the 16th century, British and French expeditions explored and later settled along the Atlantic coast. As a consequence of various armed conflicts, France ceded nearly all of its colonies in North America in 1763. In 1867, with the union of three British North American colonies through Confederation, Canada was formed as a federal dominion of four provinces. This began an accretion of provinces an ...
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Plasmodium
''Plasmodium'' is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of ''Plasmodium'' species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue (often the liver) before entering the bloodstream to infect red blood cells. The ensuing destruction of host red blood cells can result in malaria. During this infection, some parasites are picked up by a blood-feeding insect (mosquitoes in majority cases), continuing the life cycle. ''Plasmodium'' is a member of the phylum Apicomplexa, a large group of parasitic eukaryotes. Within Apicomplexa, ''Plasmodium'' is in the order Haemosporida and family Plasmodiidae. Over 200 species of ''Plasmodium'' have been described, many of which have been subdivided into 14 subgenera based on parasite morphology and host range. Evolutionary relationships among different ''Pl ...
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Neospora
''Neospora'' is a single celled parasite of livestock and companion animals. It was not discovered until 1984 in Norway, where it was found in dogs. Neosporosis, the disease that affects cattle and companion animals, has a worldwide distribution. ''Neosporosis'' causes abortions in cattle and paralysis in companion animals. It is highly transmissible and some herds can have up to a 90% prevalence. Up to 33% of pregnancies can result in aborted fetuses on one dairy farm. In many countries this organism is the main cause of abortion in cattle. Neosporosis is now considered as a major cause of abortion in cattle worldwide. Many reliable diagnostic tests are commercially available. ''Neospora caninum'' does not appear to be infectious to humans. In dogs, ''Neospora caninum'' can cause neurological signs, especially in congenitally infected puppies, where it can form cysts in the central nervous system. Genome The genome of ''Neospora caninum'' has been sequenced.Khan A, Fujita AW ...
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Leishmania
''Leishmania'' is a parasitic protozoan, a single-celled organism of the genus '' Leishmania'' that are responsible for the disease leishmaniasis. They are spread by sandflies of the genus ''Phlebotomus'' in the Old World, and of the genus ''Lutzomyia'' in the New World. At least 93 sandfly species are proven or probable vectors worldwide.WHO (2010) Annual report. Geneva Their primary hosts are vertebrates; ''Leishmania'' commonly infects hyraxes, canids, rodents, and humans. History Members of an ancient genus of the ''Leishmania'' parasite, ''Paleoleishmania'', have been detected in fossilized sand flies dating back to the early Cretaceous period. The first written reference to the conspicuous symptoms of cutaneous leishmaniasis surfaced in the Paleotropics within oriental texts dating back to the 7th century BC (allegedly transcribed from sources several hundred years older, between 1500 and 2000 BC). Due to its broad and persistent prevalence throughout antiquity as a mys ...
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Giardia
''Giardia'' ( or ) is a genus of anaerobic flagellated protozoan parasites of the phylum Metamonada that colonise and reproduce in the small intestines of several vertebrates, causing the disease giardiasis. Their life cycle alternates between a swimming trophozoite and an infective, resistant cyst. ''Giardia'' were first described by the Dutch microscopist Antonie van Leeuwenhoek in 1681. The genus is named after French zoologist Alfred Mathieu Giard. Characteristics Like other diplomonads, ''Giardia'' have two nuclei, each with four associated flagella, and were thought to lack both mitochondria and Golgi apparatuses. However, they are now known to possess a complex endomembrane system as well as mitochondrial remnants, called mitosomes, through mitochondrial reduction. The mitosomes are not used in ATP synthesis the way mitochondria are, but are involved in the maturation of iron-sulfur proteins. The synapomorphies of genus ''Giardia'' include cells with duplicate org ...
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Entamoeba
''Entamoeba'' is a genus of Amoebozoa found as internal parasites or commensals of animals. In 1875, Fedor Lösch described the first proven case of amoebic dysentery in St. Petersburg, Russia. He referred to the amoeba he observed microscopically as ''Amoeba coli''; however, it is not clear whether he was using this as a descriptive term or intended it as a formal taxonomic name. The genus ''Entamoeba'' was defined by Casagrandi and Barbagallo for the species ''Entamoeba coli'', which is known to be a commensal organism. Lösch's organism was renamed ''Entamoeba histolytica'' by Fritz Schaudinn in 1903; he later died, in 1906, from a self-inflicted infection when studying this amoeba. For a time during the first half of the 20th century the entire genus ''Entamoeba'' was transferred to ''Endamoeba'', a genus of amoebas infecting invertebrates about which little is known. This move was reversed by the International Commission on Zoological Nomenclature in the late 1950s, and ''E ...
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Cryptosporidium
''Cryptosporidium'', sometimes informally called crypto, is a genus of apicomplexan parasitic alveolates that can cause a respiratory and gastrointestinal illness (cryptosporidiosis) that primarily involves watery diarrhea (intestinal cryptosporidiosis), sometimes with a persistent cough (respiratory cryptosporidiosis). Treatment of gastrointestinal infection in humans involves fluid rehydration, electrolyte replacement, and management of any pain. , nitazoxanide is the only drug approved for the treatment of cryptosporidiosis in immunocompetent hosts. Supplemental zinc may improve symptoms, particularly in recurrent or persistent infections or in others at risk for zinc deficiency. ''Cryptosporidium'' oocysts are 4–6  μm in diameter and exhibit partial acid-fast staining. They must be differentiated from other partially acid-fast organisms including ''Cyclospora cayetanensis''. General characteristics ''Cryptosporidium'' causes cryptosporidiosis, an infection tha ...
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Crithidia
''Crithidia'' is a genus of trypanosomatid Euglenozoa. They are parasites that exclusively parasitise arthropods, mainly insects. They pass from host to host as cysts in infective faeces and typically, the parasites develop in the digestive tracts of insects and interact with the intestinal epithelium using their flagellum. They display very low host-specificity and a single parasite can infect a large range of invertebrate hosts. At different points in its life-cycle, it passes through amastigote, promastigote, and epimastigote phases; the last is particularly characteristic, and similar stages in other trypanosomes are often called crithidial. The etymology of the genus name ''Crithidia'' derives from the Ancient Greek word (), meaning "small grain of barley". Species * '' Crithidia bombi'' is perhaps the most well documented species and is the most prevalent parasite of bumblebees, including common species like ''Bombus terrestris'', '' Bombus muscorum'', and ''Bombus ho ...
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University Of Georgia
, mottoeng = "To teach, to serve, and to inquire into the nature of things.""To serve" was later added to the motto without changing the seal; the Latin motto directly translates as "To teach and to inquire into the nature of things." , established = , endowment = $1.8 billion (2021)As of June 30, 2021. , type = Public flagship land-grant research university , parent = University System of Georgia , accreditation = SACS , academic_affiliation = , president = Jere W. Morehead , provost = S. Jack Hu , city = Athens , state=Georgia , country = United States , coordinates = , faculty = 3,119 , students = 40,118 (fall 2021) , undergrad = 30,166 (fall 2021) , postgrad = 9,952 (fall 2021) , free_label2 = Newspaper , free2 = '' The Red & Black'' , campus = Midsize city / College town , campus_size = (main campus) (total) , colors = , sports_nickname = Bulldogs , sporting_affiliations = NCAA Division I FBS – SEC , mascot = Uga X (live English Bulldo ...
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