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Biogerontologist
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journaBIOGERONTOLOGYin 2000. It involves interdisciplinary research on the causes, effects, and mechanisms of biological aging. Biogerontologist Leonard Hayflick has said that the natural average lifespan for a human is around 92 years and, if humans do not invent new approaches to treat aging, they will be stuck with this lifespan. James Vaupel has predicted that life expectancy in industrialized countries will reach 100 for children born after the year 2000. Many surveyed biogerontologists have predicted life expectancies of more than three centuries for people born after the year 2100. Other scientists, more controversially, suggest the possibility of unlimited lifespans for those currently living. For example, Aubrey ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strategies For Engineered Negligible Senescence
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease.de Grey, Aubrey; Rae, Michael (September 2007). ''Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime''. New York, NY: St. Martin's Press, 416 pp. . SENS was first defined by British biogerontologist Aubrey de Grey. While some biogerontologists support the SENS program, others contend that the ultimate goals of de Grey's programme are too speculative given the current state of technology. The 31-member Research Advisory Board of de Grey's SENS Research Foundation have signed an endorsement of the plausibility of the SENS approach. Framework The term "negligible senescence" was first used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedical Gerontology
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years. Several researchers in the area, along with "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists. The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suresh Rattan
Suresh Rattan (full name: ''Suresh Inder Singh Rattan''; born in 1955 in Amritsar, India) is a biogerontologist – a researcher in the field of biology of ageing, biogerontology. In addition to his professional research work on the biology of ageing, he is also very much interested and involved in the public communication of science and he likes to undertake explorations in the Indian classical music and semi-classical music by playing Tabla – the North Indian drums, as evident from music CDs "State of the Art: Small Town People" by Harry Jokumsen and other artists (2008), and "The Fall and the Rise of a Woman" by Pearl (2014) in which he plays Tabla under his artistic name Shashi Maharaj. Academic background Suresh Rattan has been heading, since its inception in 1984, the Laboratory of Cellular Ageing at the Department of Molecular Biology and Genetics at the Aarhus University in Denmark, where he has become Emeritus since 2020. He was introduced to the field of ageing by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denham Harman
Denham Harman (February 14, 1916 – November 25, 2014) was an American medical academic who latterly served as professor emeritus at the University of Nebraska Medical Center. Harman is known as the "father of the free radical theory of aging". Background Born in San Francisco, he earned his BS and Ph.D. in 1943 from the College of Chemistry at the University of California, Berkeley and his M.D. from Stanford University, finishing his internship in 1954. Immediately after earning his Ph.D., in 1943, Harman joined the reaction kinetics department of Shell Oil in Emeryville, California. He worked for six years as a Shell research chemist, in part studying free radical reactions in petroleum products. During that period he was granted 35 patents, one for a compound used in plastic strips to kill flies ("Shell No Pest Strip"). Harman became fascinated with the phenomenon of aging, its cause and possible cure. To assist him in understanding this problem, he went to medical s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aging-associated Diseases
An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age ( with rare exceptions) but not all adult animals experience all age-associated diseases. The term does not refer to age-specific diseases, such as the childhood diseases chicken pox and measles, only diseases of the elderly. They are also not accelerated aging diseases, all of which are genetic disorders. Examples of aging-associated diseases are atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease. The incidence of all of these diseases increases exponentially with age. Of the roughly 150,000 people who die each day across the globe, about two thirds—100,000 per day—die of age-related causes. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aubrey De Grey
Aubrey David Nicholas Jasper de Grey (; born 20 April 1963) is an English author and biomedical gerontologist. He is the author of ''The Mitochondrial Free Radical Theory of Aging'' (1999) and co-author of ''Ending Aging'' (2007). He is known for his view that medical technology may enable human beings alive today not to die from age-related causes.Hang in There: The 25-Year Wait for Immortality www.livescience.com. As an amateur mathematician, he has contributed to the study of the Hadwiger–Nelson problem in [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ending Aging
''Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime'' is a 2007 book written by biogerontologist Aubrey de Grey, with his research assistant Michael Rae. ''Ending Aging'' describes de Grey's proposal for eliminating aging as a cause of debilitation and death in humans, and restoring the body to an indefinitely youthful state, a project that he calls the "strategies for engineered negligible senescence" ("SENS"). De Grey argues that defeating aging is feasible, possibly within a few decades, and he outlines steps that can be taken to hasten the development of regenerative medicine treatments for each side of aging. Editions * St. Martin's Press, 1st edition ''(hardcover, 389 pages)'', released September 4, 2007: * St. Martin's Griffin, 1st reprint edition with new afterword ''(paperback, 448 pages)'', released October 14, 2008: Translations * German: Niemals alt!: So lässt sich das Altern umkehren. Fortschritte der Verjüngungs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Longevity Escape Velocity
In the life extension movement, longevity escape velocity (LEV) or actuarial escape velocity is a hypothetical situation in which one's remaining life expectancy (not ''life expectancy at birth'') is extended longer than the time that is passing. For example, in a given year in which longevity escape velocity would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. The term is meant as an analogy to the concept of escape velocity in physics, which is the minimum speed required for an object to indefinitely move away from a gravitational body despite the gravitational force pulling the object towards the body. For many years in the past, life expectancy at each age has increased slightly every year as treatment strategies and technologies have improved. At present, more than one year of research is required for each additional year of expected life. Longevity escape velocity occurs when this ratio reverse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as '' catabolic'' – the ''breaking down'' of compounds (for example, of glucose to pyruv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peter Medawar
Sir Peter Brian Medawar (; 28 February 1915 – 2 October 1987) was a Brazilian-British biologist and writer, whose works on graft rejection and the discovery of acquired immune tolerance have been fundamental to the medical practice of tissue and organ transplants. For his scientific works, he is regarded as the "father of transplantation". He is remembered for his wit both in person and in popular writings. Famous zoologists such as Richard Dawkins referred to him as "the wittiest of all scientific writers", and Stephen Jay Gould as "the cleverest man I have ever known". Medawar was the youngest child of a Lebanese father and a British mother, and was both a Brazilian and British citizen by birth. He studied at Marlborough College and Magdalen College, Oxford, and was professor of zoology at the University of Birmingham and University College London. Until he was partially disabled by a cerebral infarction, he was Director of the National Institute for Medical Research at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication ( translesion synthesis). Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements. Mutations may or may not produce detectable changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. Mutation is the ultimate s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Selection
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Charles Darwin popularised the term "natural selection", contrasting it with artificial selection, which in his view is intentional, whereas natural selection is not. Variation exists within all populations of organisms. This occurs partly because random mutations arise in the genome of an individual organism, and their offspring can inherit such mutations. Throughout the lives of the individuals, their genomes interact with their environments to cause variations in traits. The environment of a genome includes the molecular biology in the cell, other cells, other individuals, populations, species, as well as the abiotic environment. Because individuals with certain variants of the trait tend to survive and reproduce more than individual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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