Benzofury (other)
Benzofury may refer to: * 5-APB * 5-MAPB * 6-APB * 6-MAPB 6-MAPB (1-(benzofuran-6-yl)-''N''-methylpropan-2-amine) is a psychedelic and entactogenic drug which is structurally related to 6-APB and MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in tablet form (ecstasy) and crysta ...

5-APB
5-APB (abbreviation of "5-(2-aminopropyl)benzofuran"; see infobox for the correct IUPAC name) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes. 5-APB and other compounds are sometimes informally called "Benzofury". 5-APB is commonly found as the succinate and hydrochloride salt. The hydrochloride salt is 10% more potent by mass and doses should be adjusted accordingly. 5-APB has been sold as a designer drug since 2010. Pharmacology 5-APB is a serotonin–norepinephrine–dopamine reuptake inhibitor with ''K''i(NET)=180 nmol/L, ''K''i( DAT)=265 nmol/L and ''K''i( SERT)=811 nmol/L. It is also a serotonin–norepinephrine–dopamine releasing agent. 5-APB is a potent agonist for the 5-HT2A and 5-HT2B receptors (Ki of 14 nmol/L at 5-HT2B with an efficacy of 0.924). This agonism for 5-HT2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5 ...
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5-MAPB
5-MAPB (1-(benzofuran-5-yl)-''N''-methylpropan-2-amine) is an entactogenic designer drug similar to MDMA in its structure and effects. Legal Status Canada 5-MAPB is not listed itself in the CDSA but since it is structurally related to MDMA it may be considered illegal in Canada, although this has not been tested in court. China As of October 2015 5-MAPB is a controlled substance in China. Luxembourg As of July 2021, 5-MAPB is not cited in the list of prohibited substances. Therefore, it is still a legal substance. United Kingdom 5-MAPB was originally banned in the UK in June 2013 under a Temporary class drug order. On March 5, 2014, the UK Home Office announced that 5-MAPB would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs. Pharmacokinetics Metabolism and toxicity Little formal knowledge exists on 5-MAPB. It does not form the alpha-methyldopamine metabolite that contributes to the neurotoxicity of MDM ...
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6-APB
6-APB (6-(2-aminopropyl)benzofuran) is an empathogenic psychoactive compound of the substituted benzofuran and substituted phenethylamine classes. 6-APB and other compounds are sometimes informally called "Benzofury" in newspaper reports. It is similar in structure to MDA, but differs in that the 3,4- methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. It may appear as a tan grainy powder. While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in the UK before its sale and import were banned. It falls under the category of research chemicals, sometimes called "legal highs." Because 6-APB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity. Pharmacology Pharmacodynamics 6-APB is a serotonin–norepinephrine–dopamine reuptake inhibit ...
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