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Bendectin
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride ( vitamin B6) and doxylamine succinate. It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals. Medical uses The combination of pyridoxine, commonly referred to as vitamin B6 and doxylamine may be an effective for the management of nausea and vomiting of pregnancy, but it is only recommended for use in a small number of cases after lifestyle, diet and vitamin B6. A 2018 review found the benefit was small. Doxylamine and pyridoxine are pregnancy compatible drugs,Briggs GG, Freeman RK. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition. 2015. Published by: Wolters Kluwer Health. consistent with FDA's safety assessment of the combination product. They have been categoriz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William McBride (doctor)
William Griffith McBride CBE AO (25 May 1927 – 27 June 2018) was an Australian obstetrician. He published a letter on the teratogenicity of thalidomide following the findings of a midwife named Pat Sparrow, which resulted in the reduction of the number of drugs prescribed during pregnancy. Later in his life, McBride was found guilty of separate counts of medical malpractice and scientific fraud for falsifying data in a paper that claimed that the drug Debendox was also responsible for birth defects. Biography McBride was born in Sydney, Australia. Thalidomide case McBride published a letter in ''The Lancet'', in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide, after a midwife named Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. McBride was awarded a medal and prize money by , a prestigious French institute, in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dicyclomine
Dicycloverine, also known as dicyclomine, sold under the brand name Bentyl in the US, is a medication that is used to treat spasms of the intestines such as occur in irritable bowel syndrome. It is taken by mouth or by injection into a muscle. While it has been used in baby colic and enterocolitis, evidence does not support these uses. Common side effects include dry mouth, blurry vision, weakness, sleepiness, and lightheadedness. Serious side effects may include psychosis and breathing problems in babies. Use in pregnancy appears to be safe while use during breastfeeding is not recommended. How it works is not entirely clear. Dicycloverine was approved for medical use in the United States in 1950. It is available as a generic medication. In 2020, it was the 147th most commonly prescribed medication in the United States, with more than 4million prescriptions. Medical uses Dicyclomine is used to treat the symptoms of irritable bowel syndrome, specifically hypermotility, in a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doxylamine Succinate
Doxylamine, sold under the brand name Unisom among others, is an antihistamine medication which is used in the treatment of insomnia and allergies. In combination with pyridoxine ( vitamin B6), it is also used to treat morning sickness in pregnant women. Doxylamine is available over-the-counter, and is used in nighttime cold medicines, such as NyQuil, as well as in pain medications containing acetaminophen and codeine, to help with sleep. The medication is taken by mouth. Side effects of doxylamine include dizziness, drowsiness, grogginess, and dry mouth, among others. Doxylamine is an antihistamine—specifically an inverse agonist of the histamine H1 receptor—and to a lesser extent an anticholinergic—specifically an antagonist of the muscarinic acetylcholine receptors M1 through M5. It is a first-generation antihistamine and crosses the blood–brain barrier into the brain, thereby producing centrally mediated sedative and hypnotic effects. Doxylamine was first desc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doxylamine
Doxylamine, sold under the brand name Unisom among others, is an antihistamine medication which is used in the treatment of insomnia and allergies. In combination with pyridoxine ( vitamin B6), it is also used to treat morning sickness in pregnant women. Doxylamine is available over-the-counter, and is used in nighttime cold medicines, such as NyQuil, as well as in pain medications containing acetaminophen and codeine, to help with sleep. The medication is taken by mouth. Side effects of doxylamine include dizziness, drowsiness, grogginess, and dry mouth, among others. Doxylamine is an antihistamine—specifically an inverse agonist of the histamine H1 receptor—and to a lesser extent an anticholinergic—specifically an antagonist of the muscarinic acetylcholine receptors M1 through M5. It is a first-generation antihistamine and crosses the blood–brain barrier into the brain, thereby producing centrally mediated sedative and hypnotic effects. Doxylamine was first descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doxylamine
Doxylamine, sold under the brand name Unisom among others, is an antihistamine medication which is used in the treatment of insomnia and allergies. In combination with pyridoxine ( vitamin B6), it is also used to treat morning sickness in pregnant women. Doxylamine is available over-the-counter, and is used in nighttime cold medicines, such as NyQuil, as well as in pain medications containing acetaminophen and codeine, to help with sleep. The medication is taken by mouth. Side effects of doxylamine include dizziness, drowsiness, grogginess, and dry mouth, among others. Doxylamine is an antihistamine—specifically an inverse agonist of the histamine H1 receptor—and to a lesser extent an anticholinergic—specifically an antagonist of the muscarinic acetylcholine receptors M1 through M5. It is a first-generation antihistamine and crosses the blood–brain barrier into the brain, thereby producing centrally mediated sedative and hypnotic effects. Doxylamine was first descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticholinergic
Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movement of smooth muscles present in the gastrointestinal tract, urinary tract, lungs, sweat glands, and many other parts of the body. In broad terms, anticholinergics are divided into two categories in accordance with their specific targets in the central and peripheral nervous system and at the neuromuscular junction: antimuscarinic agents, and antinicotinic agents ( ganglionic blockers, neuromuscular blockers). The term "anticholinergic" is typically used to refer to antimuscarinics which competitively inhibit the binding of ACh to muscarinic acetylcholine receptors; such agen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frye Standard
The ''Frye'' standard, ''Frye'' test, or general acceptance test is a test used in United States courts to determine the admissibility of scientific evidence. It provides that expert opinion based on a scientific technique is admissible only when the technique is generally accepted as reliable in the relevant scientific community. In ''Daubert v. Merrell Dow Pharmaceuticals'', 509 U.S. 579 (1993), the United States Supreme Court held that the Federal Rules of Evidence superseded ''Frye'' as the standard for admissibility of expert evidence in federal courts. Some states, however, still adhere to the ''Frye'' standard. History This standard comes from ''Frye v. United States'', 293 F. 1013 (D.C. Cir. 1923), a case discussing the admissibility of systolic blood pressure deception test as evidence. The Court in Frye held that expert testimony must be based on scientific methods that are sufficiently established and accepted. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Instagram
Instagram is a photo and video sharing social networking service owned by American company Meta Platforms. The app allows users to upload media that can be edited with filters and organized by hashtags and geographical tagging. Posts can be shared publicly or with preapproved followers. Users can browse other users' content by tag and location, view trending content, like photos, and follow other users to add their content to a personal feed. Instagram was originally distinguished by allowing content to be framed only in a square (1:1) aspect ratio of 640 pixels to match the display width of the iPhone at the time. In 2015, this restriction was eased with an increase to 1080 pixels. It also added messaging features, the ability to include multiple images or videos in a single post, and a Stories feature—similar to its main competitor Snapchat—which allowed users to post their content to a sequential feed, with each post accessible to others for 24 hours. As of Janu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Facebook
Facebook is an online social media and social networking service owned by American company Meta Platforms. Founded in 2004 by Mark Zuckerberg with fellow Harvard College students and roommates Eduardo Saverin, Andrew McCollum, Dustin Moskovitz, and Chris Hughes, its name comes from the face book directories often given to American university students. Membership was initially limited to Harvard students, gradually expanding to other North American universities and, since 2006, anyone over 13 years old. As of July 2022, Facebook claimed 2.93 billion monthly active users, and ranked third worldwide among the most visited websites as of July 2022. It was the most downloaded mobile app of the 2010s. Facebook can be accessed from devices with Internet connectivity, such as personal computers, tablets and smartphones. After registering, users can create a profile revealing information about themselves. They can post text, photos and multimedia which are shared with any ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kim Kardashian
Kimberly Noel Kardashian (formerly West; born October 21, 1980) is an American socialite, media personality, and businesswoman. She first gained media attention as a friend and stylist of Paris Hilton, but received wider notice after the sex tape ''Kim Kardashian, Superstar'', shot in 2003 with her then-boyfriend Ray J, was released in 2007. Later that year, she and her family began to appear in the E! reality television series ''Keeping Up with the Kardashians'' (2007–2021). Its success led to the formation of the spin-off series ''Kourtney and Kim Take New York'' (2011–2012), ''Kourtney and Kim Take Miami'' (2009–2013), and Hulu's ''The Kardashians'' (2022). Kardashian has developed a significant presence online and across numerous social media platforms, including hundreds of millions of followers on Twitter and Instagram. With sisters Kourtney and Khloé, she launched the fashion boutique chain Dash, which operated from 2006 to 2018. Kardashian founded KKW Be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melvin Belli
Melvin Mouron Belli (July 29, 1907 – July 9, 1996) was a prominent United States lawyer, writer, and actor known as "The King of Torts" and by insurance companies as "Melvin Bellicose". He had many celebrity clients, including Zsa Zsa Gabor, Errol Flynn, Chuck Berry, Muhammad Ali, The Rolling Stones, Jim Bakker and Tammy Faye Bakker, Martha Mitchell, Maureen Connolly, Lana Turner, Tony Curtis, and Mae West. During his legal career, he won over $600 million in damages for his clients. He was also the attorney for Jack Ruby, who shot Lee Harvey Oswald days after the assassination of President John F. Kennedy. Early life Belli was born in the California Gold Rush town of Sonora, California in the Sierra Nevada foothills. His parents were of Italian ancestry from Switzerland. His grandmother, Anna Mouron, was the first female pharmacist in California. By the 1920s, the family had moved to the Central Valley city of Stockton, California, where Belli attended the now-defun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daubert V
In United States federal law, the ''Daubert'' standard is a rule of evidence regarding the admissibility of expert witness testimony. A party may raise a ''Daubert'' motion, a special motion ''in limine'' raised before or during trial, to exclude the presentation of unqualified evidence to the jury. The ''Daubert'' trilogy are the three United States Supreme Court cases that articulated the ''Daubert'' standard: *'' Daubert v. Merrell Dow Pharmaceuticals, Inc.'' (1993), which held that Rule 702 of the Federal Rules of Evidence did not incorporate the ''Frye'' standard as a basis for assessing the admissibility of scientific expert testimony, but that the rule incorporated a flexible reliability standard instead; *''General Electric Co. v. Joiner'' (1997), which held that a district court judge may exclude expert testimony when there are gaps between the evidence relied on by an expert and that person's conclusion, and that an abuse-of-discretion standard of review is the proper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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