Ball And Chain Inactivation
In neuroscience, ball and chain inactivation is a model to explain the fast inactivation mechanism of voltage-gated ion channels. The process is also called hinged-lid inactivation or N-type inactivation. A voltage-gated ion channel can be in three states: open, closed, or inactivated. The inactivated state is mainly achieved through fast inactivation, by which a channel transitions rapidly from an open to an inactivated state. The model proposes that the inactivated state, which is stable and non-conducting, is caused by the physical blockage of the pore. The blockage is caused by a "ball" of amino acids connected to the main protein by a string of residues on the cytoplasmic side of the membrane. The ball enters the open channel and binds to the hydrophobic inner vestibule within the channel. This blockage causes inactivation of the channel by stopping the flow of ions. This phenomenon has mainly been studied in potassium channels and sodium channels. Discovery Electrophysiolo ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  

Inactivation Diagram
Inactivation may refer to: *Inactivated vaccine, a vaccine that consists of viruses which are grown in culture and then killed *RNA interference, also called RNA inactivation, a system that regulates the activity of genes *X-inactivation, also called lyonization, a process by which one of the two copies of the x chromosome present in female mammals is inactivated {{disambig ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]