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Bryan Molloy
Bryan Barnet Molloy (30 March 1939 – 20 May 2004) was a Scottish chemist, known notably for helping to invent the antidepressant ''Prozac'', a name for fluoxetine. ''Prozac'' was introduced in 1988, and has been the world's leading antidepressant. Early life He was born in Broughty Ferry, in the east of Dundee. He received a BSc degree in Chemistry in 1960 from the University of St Andrews, gaining a PhD in 1963. Career He moved to the US in 1963, working on research at three universities for three years, including Imperial College London. He researched the neurotransmitter acetylcholine, and its effect on the heart. Prozac He worked with David T. Wong and Klaus Schmiegel. Tricyclic antidepressants had been introduced in the 1950s, and further antidepressants included monoamine oxidase inhibitors (MAOIs); these had side-effects. In 1971, Wong and Molloy went to a lecture in Indianapolis given by Solomon H. Snyder, a neuroscientist at Johns Hopkins University. This gave them a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, headaches, sexual dysfunction, and emotional blunting. There is a slight increased risk of suicidal thinking and behavior when taken by children, adolescents, and young adults. Discontinuation syndrome may occur after stopping any antidepressant which resembles recurrent depression. Some research regarding the effectiveness of antidepressants for depression in adults has found benefits, whilst other research has not. Evidence of benefit in children and adolescents is unclear. The twenty-one most commonly prescribed antidepressant medications are more effective than placebo for the short-term (acute) treatments of adults with major depressive disorder. There is debate in the medical community about how much of the observed effects of antidep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Selective Serotonin Reuptake Inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the presynaptic cell. They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having strong affinity for the serotonin transporter and only weak affinity for the norepinephrine and dopamine transporters. SSRIs are the most widely prescribed antidepressants in many countries. The efficacy of SSRIs in mild or moderate cases of depression has been disputed and may or may not be outweighed by side effects, especially in adolescent populations. Medical uses The main indication for SSRIs is major depressive disorder; however, they are frequently prescribed for anxiety disorders, such as social anxiety disorder, ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Akron, Ohio
Akron () is the fifth-largest city in the U.S. state of Ohio and is the county seat of Summit County, Ohio, Summit County. It is located on the western edge of the Glaciated Allegheny Plateau, about south of downtown Cleveland. As of the 2020 Census, the city proper had a total population of 190,469, making it the 125th largest city in the United States. The Akron Metropolitan Statistical Area, Akron metropolitan area, covering Summit and Portage County, Ohio, Portage counties, had an estimated population of 703,505. The city was founded in 1825 by Simon Perkins and Paul Williams, along the Cuyahoga River, Little Cuyahoga River at the summit of the developing Ohio and Erie Canal. The name is derived from the Ancient Greek word ''ἄκρον : ákron'' signifying a summit or high point. It was briefly renamed South Akron after Eliakim Crosby founded nearby North Akron in 1833, until both merged into an incorporated village in 1836. In the 1910s, Akron doubled in population, makin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Inventors Hall Of Fame
The National Inventors Hall of Fame (NIHF) is an American not-for-profit organization, founded in 1973, which recognizes individual engineers and inventors who hold a U.S. patent of significant technology. Besides the Hall of Fame, it also operates a museum in Alexandria, Virginia, sponsors educational programs, and a collegiate competition. As of 2020, 603 inventors have been inducted, mostly constituting historic persons from the past three centuries, but including about 100 living inductees. Nominees must hold a U.S. patent of significant contribution to the U.S. welfare, and which advances science and useful arts. The 2020 class included 22 inventors. History The National Inventors Hall of Fame was founded in 1973 on the initiative of H. Hume Mathews, then the chairman of the National Council of Patent Law Associations (now the National Council of Intellectual Property Law Associations). It was launched by Ed Sobey, who was also the first director. In 1974, it gained a ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marion County, Indiana
Marion County is located in the U.S. state of Indiana. The 2020 United States census, 2020 United States census reported a population of 977,203, making it the largest county in the state and 51st List of the most populous counties in the United States, most populated county in the country. Indianapolis is the county seat, the List of capitals in the United States, state capital, and List of United States cities by population, largest city. Marion County is Consolidated city–county, consolidated with Indianapolis through an arrangement known as Unigov. Marion County is the central county of the Indianapolis metropolitan area, Indianapolis–Carmel–Anderson Metropolitan Statistical Area, MSA in Central Indiana. Geography The low rolling hills of Marion County have been cleared of trees, and the area is completely devoted to municipal development or to agriculture, except for wooded drainages. The highest point (920 feet/279 meters ASL) is a small ridge at the county's northwe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pilot Licensing And Certification
Pilot licensing or certification refers to permits for operating aircraft. Flight crew licences are regulated by ICAO Annex 1 and issued by the civil aviation authority of each country. CAA’s have to establish that the holder has met a specific set of knowledge and experience before issuing the licence. The licence, with added ratings, allows a pilot to fly aircraft registered in the licence issuing state. The ICAO ''Annex 1 - Personnel Licensing'' acts as the international minimum standards for licensing, however states can deviate from these standards by notifying ICAO about the changes. This, for instance, is why there are certain differences regarding licensing between EASA in Europe and the FAA in the USA. Regulation by country In the United States, pilot certification is regulated by the Federal Aviation Administration (FAA), a branch of the U.S. Department of Transportation (DOT). A pilot is certified under the authority of Parts 61 and 141 of Title 14 of the Code of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indiana
Indiana () is a U.S. state in the Midwestern United States. It is the 38th-largest by area and the 17th-most populous of the 50 States. Its capital and largest city is Indianapolis. Indiana was admitted to the United States as the 19th state on December 11, 1816. It is bordered by Lake Michigan to the northwest, Michigan to the north, Ohio to the east, the Ohio River and Kentucky to the south and southeast, and the Wabash River and Illinois to the west. Various indigenous peoples inhabited what would become Indiana for thousands of years, some of whom the U.S. government expelled between 1800 and 1836. Indiana received its name because the state was largely possessed by native tribes even after it was granted statehood. Since then, settlement patterns in Indiana have reflected regional cultural segmentation present in the Eastern United States; the state's northernmost tier was settled primarily by people from New England and New York, Central Indiana by migrants fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenethylamine
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1) and inhibiting vesicular monoamine transporter 2 (VMAT2) in monoamine neurons. To a lesser extent, it also acts as a neurotransmitter in the human central nervous system. In mammals, phenethylamine is produced from the amino acid L-phenylalanine by the enzyme aromatic L-amino acid decarboxylase via enzymatic decarboxylation. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation. Phenethylamine is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, in orally ingested phenethylamine, a significant amount is metabolized in the small intestine by monoami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Arrhythmia
Arrhythmias, also known as cardiac arrhythmias, heart arrhythmias, or dysrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. A resting heart rate that is too fast – above 100 beats per minute in adults – is called tachycardia, and a resting heart rate that is too slow – below 60 beats per minute – is called bradycardia. Some types of arrhythmias have no symptoms. Symptoms, when present, may include palpitations or feeling a pause between heartbeats. In more serious cases, there may be lightheadedness, passing out, shortness of breath or chest pain. While most cases of arrhythmia are not serious, some predispose a person to complications such as stroke or heart failure. Others may result in sudden death. Arrhythmias are often categorized into four groups: extra beats, supraventricular tachycardias, ventricular arrhythmias and bradyarrhythmias. Extra beats include premature atrial contractions, premature ventricular contra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiovascular Disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, abnormal heart rhythms, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account for approximat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WHO Model List Of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. The list is frequently used by countries to help develop their own local lists of essential medicines. , more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list. This includes both developed and developing countries. The list is divided into core items and complementary items. The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources. The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost–benefit ratio. About 25% of items are in the complementary list. Some medicatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paroxetine
Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of premature ejaculation and hot flashes due to menopause. It is taken by mouth. Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction. Serious side effects may include suicidal thoughts in those under the age of 25, serotonin syndrome, and mania. While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often. Use in pregnancy is not recommended, while use during breastfeeding is relatively safe. It is believed to work by blocking th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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