Bisthiosemicarbazone
In organic chemistry, a bisthiosemicarbazone is a derivative from an elimination reaction between a thiosemicarbazide and a diketone. Their structure is . A 'thiosemicarbazone' contains a sulfur atom in lieu of the ketonic oxygen in semicarbazone. Bisthiosemicarbazones are known to have antiviral, antimalarial and anticancer activity, usually mediated through binding to copper or iron in cells. They have also been identified as potential ligands for radioisotope delivery, with selectivity towards hypoxic tissues, particularly in the heart and brain. When chelated to zinc atoms some bisthiosemicarbazones may have uses as fluorescing agents in optical microscopy. See also *Salen ligand *Ambazone References

Functional groups Thiocarbonyl compounds Thiosemicarbazones {{Organic-chemistry-stub ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  

Salen Ligand
Salen refers to a tetradentate C2-symmetric ligand synthesized from salicylaldehyde (sal) and ethylenediamine (en). It may also refer to a class of compounds, which are structurally related to the classical salen ligand, primarily bis-Schiff bases. Salen ligands are notable for coordinating a wide range of different metals, which they can often stabilise in various oxidation states. For this reason salen-type compounds are used as metal deactivators. Metal salen complexes also find use as catalysts. Synthesis and properties H2salen may be synthesized by the condensation of ethylenediamine and salicylaldehyde. : Complexes of salen with metal cations may be made without isolating it from the reaction mixture. This is possible because the stability constant for the formation of the metal complexes are very high, due to the chelate effect. :H2L + Mn+ → ML(n−2)+ + 2 H+ where L stands for the ligand. The pyridine adduct of the cobalt(II) complex Co(salen)(py) ( salcomine) ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]