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BigBrain
BigBrain is a freely accessible high-resolution 3D digital atlas of the human brain, released in June 2013 by a team of researchers at the Montreal Neurological Institute and the German Forschungszentrum Jülich and is part of the European Human Brain Project. The isotropic 3D spatial resolution of the BigBrain atlas is 20 μm, much finer than the typical 1 mm resolution of other existing 3D models of the human brain such as the Allen Brain Atlas. In 2014, BigBrain was cited in the top 10 MIT Technology Review. Acquisition The atlas was created from the brain of an unidentified 65-year-old man (it was "65-year-old female", according to "BigBrain: An Ultrahigh-Resolution3D Human Brain Model", page 1472, Amunts K et al, SCIENCE, 21 JUNE 2013 VOL 340) who died with no known brain pathology. His brain, after being removed from the skull, was first scanned using an MRI machine, then embedded in paraffin and sliced into 7,404 20 μm thick sections using a large-scale mic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain Atlas
A brain atlas is composed of serial sections along different anatomical planes of the healthy or diseased developing or adult animal or human brain where each relevant brain structure is assigned a number of coordinates to define its outline or volume. Brain atlases are contiguous, comprehensive results of visual brain mapping and may include anatomical, genetic or functional features. A functional brain atlas is made up of N regions of interest, where these regions are typically defined as spatially contiguous and functionally coherent patches of gray matter. In most atlases, the three dimensions are: latero-lateral (x), dorso-ventral (y) and rostro- caudal (z). The possible sections are * coronal * sagittal * transverse Surface maps are sometimes used in addition to the 3D serial section maps Besides the human brain, brain atlases exist for the brains of the mouse, rhesus macaques, ''Drosophila'', pig and others. Notable examples include the Allen Brain Atlas, BrainMaps, Bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Outline Of Brain Mapping
The following outline is provided as an overview of and topical guide to brain mapping: Brain mapping – set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps. Brain mapping is further defined as the study of the anatomy and function of the brain and spinal cord through the use of imaging (including intra-operative, microscopic, endoscopic and multi-modality imaging), immunohistochemistry, molecular and optogenetics, stem cell and cellular biology, engineering (material, electrical and biomedical), neurophysiology and nanotechnology. Broad scope * History of neuroscience * History of neurology * Brain mapping * Human brain * Neuroscience * Nervous system. The neuron doctrine * Neuron doctrine – A set of carefully constructed elementary set of observations regarding neurons. ''For more granularity, more current, and more advanced topics, see the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grey Matter
Grey matter is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries. Grey matter is distinguished from white matter in that it contains numerous cell bodies and relatively few myelinated axons, while white matter contains relatively few cell bodies and is composed chiefly of long-range myelinated axons. The colour difference arises mainly from the whiteness of myelin. In living tissue, grey matter actually has a very light grey colour with yellowish or pinkish hues, which come from capillary blood vessels and neuronal cell bodies. Structure Grey matter refers to unmyelinated neurons and other cells of the central nervous system. It is present in the brain, brainstem and cerebellum, and present throughout the spinal cord. Grey matter is distributed at the surface of the cerebral hemispheres (cerebral cortex) and of the cerebellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Neuroscience
Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to understand the principles that govern the development, structure, physiology and cognitive abilities of the nervous system. Computational neuroscience employs computational simulations to validate and solve mathematical models, and so can be seen as a sub-field of theoretical neuroscience; however, the two fields are often synonymous. The term mathematical neuroscience is also used sometimes, to stress the quantitative nature of the field. Computational neuroscience focuses on the description of biologically plausible neurons (and neural systems) and their physiology and dynamics, and it is therefore not directly concerned with biologically unrealistic models used in connectionism, control theory, cybernetics, quantitative psychology, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Outline Of The Human Brain
The following outline is provided as an overview of and topical guide to the human brain: Human brain – central organ of the nervous system located in the head of a human being, protected by the skull. It has the same general structure as the brains of other mammals, but with a more developed cerebral cortex than any other, leading to the evolutionary success of widespread dominance of the human species across the planet. While the emphasis below is on physical brain structure, functional aspects are also included. Mind concepts (as in mind vs. body), and cognitive and behavioral aspects, are introduced where they have at least a fairly direct connection to physical aspects of the brain, neurons, spinal cord, nerve networks, neurotransmitters, etc. Structure of the human brain This major section covers the physical structure of the brain. Visible anatomy Basic structure * Human brain * List of regions in the human brain * Lobes of the brain * Brain ** Basal ganglia ** Br ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histology
Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures visible without a microscope. Although one may divide microscopic anatomy into ''organology'', the study of organs, ''histology'', the study of tissues, and ''cytology'', the study of cells, modern usage places all of these topics under the field of histology. In medicine, histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. In the field of paleontology, the term paleohistology refers to the histology of fossil organisms. Biological tissues Animal tissue classification There are four basic types of animal tissues: muscle tissue, nervous tissue, connective tissue, and epithelial tissue. All animal tissues are considered to be subtypes of these four principal tissue types ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artifact (error)
In natural science and signal processing, an artifact or artefact is any error An error (from the Latin ''error'', meaning "wandering") is an action which is inaccurate or incorrect. In some usages, an error is synonymous with a mistake. The etymology derives from the Latin term 'errare', meaning 'to stray'. In statistics ... in the perception or representation of any information introduced by the involved equipment or technique(s). Computer science In ''computer science'', digital artifacts are anomalies introduced into digital signals as a result of digital signal processing. Microscopy In ''microscopy'', visual artifacts are sometimes introduced during the processing of samples into microscopic slide, slide form. Econometrics In ''econometrics'', which trades on computing relationships between related Variable (mathematics), variables, an artifact is a spurious finding, such as one based on either a faulty choice of variables or an over-extension of the computed relati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flatbed Scanner
An image scanner—often abbreviated to just scanner—is a device that optically scans images, printed text, handwriting or an object and converts it to a digital image. Commonly used in offices are variations of the desktop ''flatbed scanner'' where the document is placed on a glass window for scanning. ''Hand-held scanners'', where the device is moved by hand, have evolved from text scanning "wands" to 3D scanners used for industrial design, reverse engineering, test and measurement, orthotics, gaming and other applications. Mechanically driven scanners that move the document are typically used for large-format documents, where a flatbed design would be impractical. Modern scanners typically use a charge-coupled device (CCD) or a contact image sensor (CIS) as the image sensor, whereas ''drum scanners'', developed earlier and still used for the highest possible image quality, use a photomultiplier tube (PMT) as the image sensor. A ''rotary scanner,'' used for high-speed document ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White Matter
White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, also called tracts. Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distribution of action potentials, acting as a relay and coordinating communication between different brain regions. White matter is named for its relatively light appearance resulting from the lipid content of myelin. However, the tissue of the freshly cut brain appears pinkish-white to the naked eye because myelin is composed largely of lipid tissue veined with capillaries. Its white color in prepared specimens is due to its usual preservation in formaldehyde. Structure White matter White matter is composed of bundles, which connect various grey matter areas (the locations of nerve cell bodies) of the brain to each other, and carry nerve impulses between neurons. Myelin acts as an insulator, which allows electrical signals to jump, rather than c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Staining
Staining is a technique used to enhance contrast in samples, generally at the microscopic level. Stains and dyes are frequently used in histology (microscopic study of biological tissues), in cytology (microscopic study of cells), and in the medical fields of histopathology, hematology, and cytopathology that focus on the study and diagnoses of diseases at the microscopic level. Stains may be used to define biological tissues (highlighting, for example, muscle fibers or connective tissue), cell populations (classifying different blood cells), or organelles within individual cells. In biochemistry, it involves adding a class-specific ( DNA, proteins, lipids, carbohydrates) dye to a substrate to qualify or quantify the presence of a specific compound. Staining and fluorescent tagging can serve similar purposes. Biological staining is also used to mark cells in flow cytometry, and to flag proteins or nucleic acids in gel electrophoresis. Light microscopes are used for viewin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Brain
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and occipital lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microtome
A microtome (from the Greek ''mikros'', meaning "small", and ''temnein'', meaning "to cut") is a cutting tool used to produce extremely thin slices of material known as ''sections''. Important in science, microtomes are used in microscopy, allowing for the preparation of samples for observation under transmitted light or electron radiation. Microtomes use steel, glass or diamond blades depending upon the specimen being sliced and the desired thickness of the sections being cut. Steel blades are used to prepare histological sections of animal or plant tissues for light microscopy. Glass knives are used to slice sections for light microscopy and to slice very thin sections for electron microscopy. Industrial grade diamond knives are used to slice hard materials such as bone, teeth and tough plant matter for both light microscopy and for electron microscopy. Gem-quality diamond knives are also used for slicing thin sections for electron microscopy. Microtomy is a method for the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
