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Bernard Brodie (biochemist)
Bernard Beryl Brodie (7 August 1907 – 28 February 1989) was an English scientist. A leading researcher on drug therapy, he is considered by many to be the founder of modern pharmacology and brought the field to prominence in the 1940s and 1950s. He was a major figure in the field of drug metabolism, the study of how drugs interact in the body and how they are absorbed. A member of the United States National Academy of Sciences, Brodie was a founder and former chief of the Laboratory of Chemical Pharmacology at the National Heart Institute of the National Institutes of Health in Bethesda, Maryland. Early life and education Born in Liverpool in 1907, to a Jewish family Brodie did his undergraduate work at McGill University and received a Ph.D. in chemistry at New York University in 1935. After his graduation from N.Y.U., he was an associate professor there until 1950, when he joined the National Institutes of Health. He headed the pharmacology laboratory there until his r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liverpool
Liverpool is a city and metropolitan borough in Merseyside, England. With a population of in 2019, it is the 10th largest English district by population and its metropolitan area is the fifth largest in the United Kingdom, with a population of 2.24 million. On the eastern side of the Mersey Estuary, Liverpool historically lay within the ancient hundred of West Derby in the county of Lancashire. It became a borough in 1207, a city in 1880, and a county borough independent of the newly-created Lancashire County Council in 1889. Its growth as a major port was paralleled by the expansion of the city throughout the Industrial Revolution. Along with general cargo, freight, and raw materials such as coal and cotton, merchants were involved in the slave trade. In the 19th century, Liverpool was a major port of departure for English and Irish emigrants to North America. It was also home to both the Cunard and White Star Lines, and was the port of registry of the ocean li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten by an infected mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. Malaria is caused by single-celled microorganisms of the ''Plasmodium'' group. It is spread exclusively through bites of infected ''Anopheles'' mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of ''Plasmodium'' can infect and be spread by h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1989 Deaths
File:1989 Events Collage.png, From left, clockwise: The Cypress Street Viaduct, Cypress structure collapses as a result of the 1989 Loma Prieta earthquake, killing motorists below; The proposal document for the World Wide Web is submitted; The Exxon Valdez oil tanker runs aground in Prince William Sound, Alaska, causing a large Exxon Valdez oil spill, oil spill; The Fall of the Berlin Wall begins the downfall of Communism in Eastern Europe, and heralds German reunification; The United States United States invasion of Panama, invades Panama to depose Manuel Noriega; The Singing Revolution led to the independence of the Baltic states of Estonia, Latvia, and Lithuania from the Soviet Union; The stands of Hillsborough Stadium in Sheffield, Yorkshire, where the Hillsborough disaster occurred; 1989 Tiananmen Square protests and massacre, Students demonstrate in Tiananmen Square, Beijing; many are killed by forces of the Chinese Communist Party., 300x300px, thumb rect 0 0 200 200 1989 Loma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maurice Brodie
Maurice Brodie (1903–1939) was a British-born American virologist who developed a polio vaccine in 1935. Early years and education Brodie was born in Liverpool, England, the son of Samuel Broude and Esther Ginsburg. The family immigrated to Ottawa, Canada, in 1910. Maurice graduated from Lisgar Collegiate Institute and McGill University Faculty of Medicine The Faculty of Medicine and Health Sciences is one of the constituent faculties of McGill University. It was established in 1829 after the Montreal Medical Institution was incorporated into McGill College as the college's first faculty; it was t ..., Alpha Omega Alpha, in 1928; he was named a Wood Gold Medalist. He served as a medical intern, and in 1931 he received a Master of Science degree in physiology from McGill. Brodie belonged to the McGill chapter of Sigma Alpha Mu, and had been a staff reporter of the Ottawa Citizen, 1927–1928. At McGill 1932 he received a grant from the Banting Research Foundation for his studie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gian Luigi Gessa
Gian Luigi Gessa is a professor of Neuropsychopharmacology at the University of Cagliari, where he has led for a long time the Department of Neurosciences. He is the leader of the Italian group that studies drug addiction. He also directed the research groups of the National Research Council. He worked as a researcher at the National Institutes of Health by Bethesda (Maryland) led by Professor Bernard Brodie and Scripps Research Institute of La Jolla (California), before returning to Italy and becoming one of the most authoritative experts in neuropharmacological research. Under his leadership, the Department of Neuroscience of University of Cagliari was ranked twenty-third place in the world among research institutes in the field of Pharmacology (Xenobiotics, Current Contents, Life Sciences, 1993). The Neuropharmacology department of Cagliari was also recognized by the Ministry of University and Scientific Research as a "Center of Excellence" for research on the Neurobiolog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cagliari
The University of Cagliari ( it, Università degli Studi di Cagliari) is a university in Cagliari, Sardinia, Italy. It was founded in 1606 and is organized in 11 faculties. History The ''Studium Generalis Kalaritanum'' was founded in 1606 along the lines of the old Spanish Universities of Salamanca, Valladolid and Lleida, but it begins to operate only after the privilege of King Philip III in 1620. as ''Universidad y Estudio General de Caller en el Reyno de Cerdeña'' (University and Gener Study of Cagliari in the Kingdom of Sardinia). It originally offered Law, Latin, Greek and Hebrew Literature, the Liberal Arts, Medicine, Surgery, Philosophy and Science. When Sardinia passed under the House of Savoy government in the 18th century, the statute of the University was significantly modified, with the expansion of the science faculties and institutes. Designed by the Piedmontese engineer Saverio Belgrano di Famolasco, the new university building was completed at the end of the 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, decreased emotional expression, and apathy. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a history that includes the person's reported experiences, and reports of others familiar with the person. To be diagnosed with schizophrenia, symptoms and functional impairment need to be present for six months (DSM-5) or one month (ICD-11). Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder. About 0.3% to 0.7% of people are diagnosed with schizophrenia during their lifetime. In 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad'', "near", and '' ren'', "kidney") is more commonly used in the United Kingdom, whereas "norepinephrine" (from Ancient Greek ἐπῐ́ (''epí''), "upon", and νεφρός (''nephrós''), "kidney") is usually preferred in the United States. "Norepinephrine" is also the international nonproprietary name given to the drug. Regardless of which name is used for the substance itself, parts of the body that produce or are affected by it are referred to as noradrenergic. The general function of norepinephrine is to mobilize the brain and body for action. Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin
Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction. Approximately 90% of the serotonin that the body produces is in the intestinal tract. Biochemically, the indoleamine molecule derives from the amino acid tryptophan, via the (rate-limiting) hydroxylation of the 5 position on the ring (forming the intermediate 5-hydroxytryptophan), and then decarboxylation to produce serotonin. Serotonin is primarily found in the enteric nervous system located in the gastrointestinal tract (GI tract). However, it is also produced in the central nervous system (CNS), specifically in the raphe nuclei located in the brainstem, Merkel cells located in the skin, pulmonary neuroendocrine cells and taste receptor cells in the tongue. Additionally, serotonin is stored in blood platelets and is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Procainamide
Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is classified by the Vaughan Williams classification system as class Ia; thus it is a sodium channel blocker of cardiomyocytes. In addition to blocking the ''I''Na current, it inhibits the ''I''Kr rectifier K+ current. Procainamide is also known to induce a voltage-dependent open channel block on the batrachotoxin (BTX)-activated sodium channels in cardiomyocytes. Uses Medical Procainamide is used for treating ventricular arrhythmias: ventricular ectopy and tachycardia and supraventricular arrhythmias: atrial fibrillation, and re-entrant and automatic supraventricular tachycardia. For example, it can be used to convert new-onset atrial fibrillation, and although was initially thought to be suboptimal for this purpose, a growing body of literature is amounting in support for this exact cause. It is administered by mouth, by intramuscular injection, or intravenously. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methemoglobinemia
Methemoglobinemia, or methaemoglobinaemia, is a condition of elevated methemoglobin in the blood. Symptoms may include headache, dizziness, shortness of breath, nausea, poor muscle coordination, and blue-colored skin (cyanosis). Complications may include seizures and heart arrhythmias. Methemoglobinemia can be due to certain medications, chemicals, or food or it can be inherited from a person's parents. Substances involved may include benzocaine, nitrates, or dapsone. The underlying mechanism involves some of the iron in hemoglobin being converted from the ferrous e2+to the ferric e3+form. The diagnosis is often suspected based on symptoms and a low blood oxygen that does not improve with oxygen therapy. Diagnosis is confirmed by a blood gas. Treatment is generally with oxygen therapy and methylene blue. Other treatments may include vitamin C, exchange transfusion, and hyperbaric oxygen therapy. Outcomes are generally good with treatment. Methemoglobinemia is relatively u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paracetamol
Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior to ibuprofen in that respect, and the benefits of its use for fever are unclear. Paracetamol may relieve pain in acute mild migraine but only slightly in episodic tension headache. However, the aspirin/paracetamol/caffeine combination helps with both conditions where the pain is mild and is recommended as a first-line treatment for them. Paracetamol is effective for post-surgical pain, but it is inferior to ibuprofen. The paracetamol/ibuprofen combination provides further increase in potency and is superior to either drug alone. The pain relief paracetamol provides in osteoarthritis is small and clinically insignificant. The evidence in its favor for the use in low back pain, cancer pain, and neuropathic pain is insufficient. In the sho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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