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BerEp4
BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC). It is an antibody to EpCAM (epithelial cell adhesion molecule Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, prol ...). Clinical use BerEp4 has a high sensitivity and specificity in being positive only in BCC cells. BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body. It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4).{{cite journal, last1=Ordóñez, first1=Nelson G., title=Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basal Cell Carcinoma
Basal-cell carcinoma (BCC), also known as basal-cell cancer, is the most common type of skin cancer. It often appears as a painless raised area of skin, which may be shiny with small blood vessels running over it. It may also present as a raised area with ulceration. Basal-cell cancer grows slowly and can damage the tissue around it, but it is unlikely to spread to distant areas or result in death. Risk factors include exposure to ultraviolet light, having lighter skin, radiation therapy, long-term exposure to arsenic and poor immune-system function. Exposure to UV light during childhood is particularly harmful. Tanning beds have become another common source of ultraviolet radiation. Diagnosis often depends on skin examination, confirmed by tissue biopsy. It remains unclear whether sunscreen affects the risk of basal-cell cancer. Treatment is typically by surgical removal. This can be by simple excision if the cancer is small; otherwise, Mohs surgery is generally recomme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epithelial Cell Adhesion Molecule
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies. Expression pattern First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different times. EpCAM therefore has many aliases the most notable ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Histologic Stains That Aid In Diagnosis Of Cutaneous Conditions
A number of histologic stains are used in the field of dermatology that aid in the diagnosis of conditions of or affecting the human integumentary system. Footnotes See also * List of conditions associated with café au lait macules * List of contact allergens *List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer *List of cutaneous conditions associated with internal malignancy *List of cutaneous conditions caused by mutations in keratins *List of cutaneous neoplasms associated with systemic syndromes *List of cutaneous conditions caused by problems with junctional proteins *List of dental abnormalities associated with cutaneous conditions *List of genes mutated in cutaneous conditions *List of genes mutated in pigmented cutaneous lesions *List of human leukocyte antigen alleles associated with cutaneous conditions *List of immunofluorescence findings for autoimmune bullous conditions * List of inclusion bodies that aid in diagnosis of c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BCC With Squamous Cell Metaplasia With HE And BerEP4 Staining
BCC may refer to: Economics * Central Bank of the Comoros (Banque Centrale des Comores) * Central Bank of Cuba (Banco Central de Cuba) * Central Bank of the Congo (Banque Centrale du Congo) * Bamburi Cement, in Africa * British Chambers of Commerce, a national network of accredited Chambers of Commerce across the UK * Bitconnect, a kind of cryptocurrency * Bitcoin Cash, a kind of cryptocurrency (more common symbol is BCH) Education ; Australia * Ballarat and Clarendon College, a K–12 school in Ballarat, Victoria * Brindabella Christian College, a Christian primary through senior college in Australian Capital Territory ; Bangladesh * Barisal Cadet College, one of the Cadet Colleges of Bangladesh ; Barbados * Barbados Community College ; Canada * Barrie Central Collegiate Institute, a high school in Barrie, Ontario ; Philippines * Bacolod Christian Center, a preschool in Bacolod, Negros Occidental ; Thailand * Bangkok Christian College, a private school in Bangkok ; Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Superficial BCC With HE And BerEP4
{{disambiguation ...
Superficial may refer to: *Superficial anatomy, is the study of the external features of the body *Superficiality, the discourses in philosophy regarding social relation * Superficial charm, the tendency to be smooth, engaging, charming, slick and verbally facile *Superficial sympathy, false or insincere display of emotion such as a hypocrite crying fake tears of grief In entertainment * ''Superficial'' (album), an album by Heidi Montag, or its title track * The Superficial, a website devoted to celebrity gossip * "Superficial", a song by Natalia Kills from the album '' Perfectionist'' See also *Artificial (other) *Synthetic (other) *Man-made (other) Man-made refers to something that is artificial. Man-made may also refer to: * Man-made hazard *''Man-Made'', an album by British alternative rock band Teenage Fanclub *"Man Made", a song by A Flock of Seagulls on their album '' A Flock of Seagul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mayo Clinic
The Mayo Clinic () is a nonprofit American academic medical center focused on integrated health care, education, and research. It employs over 4,500 physicians and scientists, along with another 58,400 administrative and allied health staff, across three major campuses: Rochester, Minnesota; Jacksonville, Florida; and Phoenix/Scottsdale, Arizona. The practice specializes in treating difficult cases through tertiary care and destination medicine. It is home to the top-15 ranked Mayo Clinic Alix School of Medicine in addition to many of the highest regarded residency education programs in the United States. It spends over $660 million a year on research and has more than 3,000 full-time research personnel. William Worrall Mayo settled his family in Rochester in 1864 and opened a sole proprietorship medical practice that evolved under his sons, Will and Charlie Mayo, along with practice partners Stinchfield, Graham, Plummer, Millet, Judd, and Balfour, into Mayo Clini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesothelioma
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium). The most common area affected is the lining of the lungs and chest wall. Less commonly the lining of the abdomen and rarely the sac surrounding the heart, or the sac surrounding the testis may be affected. Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lung, a swollen abdomen, chest wall pain, cough, feeling tired, and weight loss. These symptoms typically come on slowly. More than 80% of mesothelioma cases are caused by exposure to asbestos. The greater the exposure the greater the risk. As of 2013, about 125 million people worldwide have been exposed to asbestos at work. High rates of disease occur in people who mine asbestos, produce products from asbestos, work with asbestos products, live with asbestos workers, or work in buildings containing asbestos. Asbestos exposure and the ons ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histology
Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures visible without a microscope. Although one may divide microscopic anatomy into ''organology'', the study of organs, ''histology'', the study of tissues, and ''cytology'', the study of cells, modern usage places all of these topics under the field of histology. In medicine, histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. In the field of paleontology, the term paleohistology refers to the histology of fossil organisms. Biological tissues Animal tissue classification There are four basic types of animal tissues: muscle tissue, nervous tissue, connective tissue, and epithelial tissue. All animal tissues are considered to be subtypes of these four principal tissue type ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncology
Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ónkos''), meaning "tumor", "volume" or "mass". Oncology is concerned with: * The diagnosis of any cancer in a person (pathology) * Therapy (e.g. surgery, chemotherapy, radiotherapy and other modalities) * Follow-up of cancer patients after successful treatment * Palliative care of patients with terminal malignancies * Ethical questions surrounding cancer care * Screening efforts: ** of populations, or ** of the relatives of patients (in types of cancer that are thought to have a hereditary basis, such as breast cancer) Diagnosis Medical histories remain an important screening tool: the character of the complaints and nonspecific symptoms (such as fatigue, weight loss, unexplained anemia, fever of unknown origin, paraneoplasti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
