|
Beckman Center For Molecular And Genetic Medicine
The Beckman Center for Molecular and Genetic Medicine is an interdisciplinary center, part of Stanford School of Medicine at Stanford University, Stanford, California. Considered a "unique facility", it was one of the first research centers to take a translational medicine approach to molecular and medical genetics. History An interdisciplinary center for molecular and genetic medicine at the Stanford School of Medicine was proposed in the 1980s by Paul Berg, Arthur Kornberg, Donald Kennedy and others. Berg has said, "At the time, our goal was to focus on the molecular and genetic basis of disease as the starting point for new forms of medicine... We wanted to improve the process by which studies at the most fundamental level could be translated into medical practice." This type of "bench-to-bedside" approach has since been termed translational medicine. The center was privately funded. Paul Berg obtained the support of philanthropists Arnold O. Beckman (1900-2004) and his wif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lucy Shapiro
Lucy Shapiro (born July 16, 1940, New York City) is an American developmental biologist. She is a professor of Developmental Biology at the Stanford University School of Medicine. She is the Virginia and D.K. Ludwig Professor of Cancer Research and the director of the Beckman Center for Molecular and Genetic Medicine. Shapiro founded a new field in developmental biology, using microorganisms to examine fundamental questions in developmental biology. Her work has furthered understanding of the basis of stem cell function and the generation of biological diversity. Her ideas have revolutionized understanding of bacterial genetic networks and helped researchers to develop novel drugs to fight antibiotic resistance and emerging infectious diseases. In 2013, Shapiro was presented with the 2011 National Medal of Science. for "her pioneering discovery that the bacterial cell is controlled by an integrated genetic circuit functioning in time and space that serves as a systems eng ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patrick O
Patrick may refer to: * Patrick (given name), list of people and fictional characters with this name *Patrick (surname), list of people with this name People * Saint Patrick (c. 385–c. 461), Christian saint *Gilla Pátraic (died 1084), Patrick or Patricius, Bishop of Dublin * Patrick, 1st Earl of Salisbury (c. 1122–1168), Anglo-Norman nobleman * Patrick (footballer, born 1983), Brazilian right-back *Patrick (footballer, born 1985), Brazilian striker *Patrick (footballer, born 1992), Brazilian midfielder * Patrick (footballer, born 1994), Brazilian right-back *Patrick (footballer, born May 1998), Brazilian forward *Patrick (footballer, born November 1998), Brazilian attacking midfielder * Patrick (footballer, born 1999), Brazilian defender * Patrick (footballer, born 2000), Brazilian defender *John Byrne (Scottish playwright) (born 1940), also a painter under the pseudonym Patrick *Don Harris (wrestler) (born 1960), American professional wrestler who uses the ring name Patrick ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly" or "pomace fly". Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. As of 2017, five Nobel Prizes have been awarded to drosophilists for their work using the insect. ''D. melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. It was originally an African species, with all non-African lineages having a common origin. Its geographic range includes all continents, including islands. ''D. melanogaster'' is a common pest in homes, restaurants, and othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mice
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus''). Mice are also popular as pets. In some places, certain kinds of field mice are locally common. They are known to invade homes for food and shelter. Mice are typically distinguished from rats by their size. Generally, when a muroid rodent is discovered, its common name includes the term ''mouse'' if it is smaller, or ''rat'' if it is larger. The common terms ''rat'' and ''mouse'' are not taxonomically specific. Typical mice are classified in the genus '' Mus'', but the term ''mouse'' is not confined to members of ''Mus'' and can also apply to species from other genera such as the deer mouse, ''Peromyscus''. Domestic mice sold as pets often differ substantially in size from the common house mouse. This is attributable to breeding a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wnt Signaling Pathway
The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part by the SPATS1 gene. The noncanonical plana ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roel Nusse
Roeland "Roel" Nusse (born 9 June 1950, Amsterdam) is a professor at Stanford University and an investigator at the Howard Hughes Medical Institute. His research was seminal in the discovery of Wnt signaling, a family of pleiotropic regulators involved in development and disease. Research Nusse received his BSc in biology and his PhD from the University of Amsterdam. Nusse did a postdoctoral fellowship under the guidance of Harold Varmus at the University of California, San Francisco. In 1982, Nusse and Varmus discovered the Wnt1 gene. After his postdoctoral fellowship, Nusse joined the Netherlands Cancer Institute expanding on the earlier work on the Wnt pathway and identifying the pathway in fruit flies. In 1990, he joined the department of Developmental Biology at Stanford University. His lab is currently focused on the role of Wnt in stem cell development and tissue repair. Awards Nusse received the Peter Debye Prize from the University of Maastricht in 2000. He is a membe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zebrafish
The zebrafish (''Danio rerio'') is a freshwater fish belonging to the minnow family ( Cyprinidae) of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a "tropical fish" although both tropical and subtropical). It is also found in private ponds. The zebrafish is an important and widely used vertebrate model organism in scientific research, for example in drug development, in particular pre-clinical development. It is also notable for its regenerative abilities, and has been modified by researchers to produce many transgenic strains. Taxonomy The zebrafish is a derived member of the genus '' Brachydanio'', of the family Cyprinidae. It has a sister-group relationship with ''Danio aesculapii''. Zebrafish are also closely related to the genus ''Devario'', as demonstrated by a phylogenetic tree of close species. Distribution Range The zebrafish is native to fresh water h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Three-spined Stickleback
The three-spined stickleback (''Gasterosteus aculeatus'') is a fish native to most inland and coastal waters north of 30°N. It has long been a subject of scientific study for many reasons. It shows great morphological variation throughout its range, ideal for questions about evolution and population genetics. Many populations are anadromous (they live in seawater but breed in fresh or brackish water) and very tolerant of changes in salinity, a subject of interest to physiologists. It displays elaborate breeding behavior (defending a territory, building a nest, taking care of the eggs and fry) and it can be social (living in shoals outside the breeding season) making it a popular subject of inquiry in fish ethology and behavioral ecology. Its antipredator adaptations, host-parasite interactions, sensory physiology, reproductive physiology, and endocrinology have also been much studied. Facilitating these studies is the fact that the three-spined stickleback is easy to find in natur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caulobacter Crescentus
''Caulobacter crescentus'' is a Gram-negative, oligotrophic bacterium widely distributed in fresh water lakes and streams. The taxon is more properly known as ''Caulobacter vibrioides'' (Henrici and Johnson 1935). ''C. crescentus'' is an important model organism for studying the regulation of the cell cycle, asymmetric cell division, and cellular differentiation. ''Caulobacter'' daughter cells have two very different forms. One daughter is a mobile "swarmer" cell that has a single flagellum at one cell pole that provides swimming motility for chemotaxis. The other daughter, called the "stalked" cell, has a tubular stalk structure protruding from one pole that has an adhesive holdfast material on its end, with which the stalked cell can adhere to surfaces. Swarmer cells differentiate into stalked cells after a short period of motility. Chromosome replication and cell division only occurs in the stalked cell stage. ''C. crescentus'' derives its name from its crescent sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stanford University Bio-X Initiative
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considered among the most prestigious universities in the world. Stanford was founded in 1885 by Leland and Jane Stanford in memory of their only child, Leland Stanford Jr., who had died of typhoid fever at age 15 the previous year. Leland Stanford was a U.S. senator and former governor of California who made his fortune as a railroad tycoon. The school admitted its first students on October 1, 1891, as a coeducational and non-denominational institution. Stanford University struggled financially after the death of Leland Stanford in 1893 and again after much of the campus was damaged by the 1906 San Francisco earthquake. Following World War II, provost of Stanford Frederick Terman inspired and supported faculty and graduates' entrepreneurialism t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steven Chu
Steven Chu''Chu, Steven'' was elected a fellow of the American Physical Society in 1986 for his contributions in atomic physics and laser spectroscopy, including the first observation of parity non-conservation in atoms, excitation and precision spectroscopy of positronium, and the optical confinement and cooling of atoms. (born February 28, 1948) is an American Experimental physics, physicist and former government official. He is a Nobel laureate and was the 12th United States Secretary of Energy. He is currently the William R. Kenan Jr. Professor of Physics and Professor of Molecular and Cellular Physiology at Stanford University. He is known for his research at the University of California, Berkel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
