Roeland "Roel" Nusse (born 9 June 1950,
Amsterdam
Amsterdam ( , , , lit. ''The Dam on the River Amstel'') is the Capital of the Netherlands, capital and Municipalities of the Netherlands, most populous city of the Netherlands, with The Hague being the seat of government. It has a population ...
) is a professor at
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
and an investigator at the
Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...
.
His research was seminal in the discovery of
Wnt signaling
The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling p ...
, a family of pleiotropic regulators involved in development and disease.
Research
Nusse received his BSc in biology and his
PhD PHD or PhD may refer to:
* Doctor of Philosophy (PhD), an academic qualification
Entertainment
* '' PhD: Phantasy Degree'', a Korean comic series
* ''Piled Higher and Deeper'', a web comic
* Ph.D. (band), a 1980s British group
** Ph.D. (Ph.D. albu ...
from the
University of Amsterdam
The University of Amsterdam (abbreviated as UvA, nl, Universiteit van Amsterdam) is a public research university located in Amsterdam, Netherlands. The UvA is one of two large, publicly funded research universities in the city, the other being ...
. Nusse did a postdoctoral fellowship under the guidance of
Harold Varmus
Harold Eliot Varmus (born December 18, 1939) is an American Nobel Prize-winning scientist. He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center.
He was a ...
at the
University of California, San Francisco
The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...
. In 1982, Nusse and Varmus discovered the
Wnt1
Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the () gene.
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated ...
gene.
After his postdoctoral fellowship, Nusse joined the Netherlands Cancer Institute expanding on the earlier work on the Wnt pathway and identifying the pathway in fruit flies. In 1990, he joined the department of
Developmental Biology
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...
at
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
. His lab is currently focused on the role of Wnt in stem cell development and tissue repair.
Awards
Nusse received the
Peter Debye
Peter Joseph William Debye (; ; March 24, 1884 – November 2, 1966) was a Dutch-American physicist and physical chemist, and Nobel laureate in Chemistry.
Biography
Early life
Born Petrus Josephus Wilhelmus Debije in Maastricht, Netherlands, D ...
Prize from the
University of Maastricht
Maastricht University (abbreviated as UM; nl, Universiteit Maastricht) is a public research university in Maastricht, Netherlands. Founded in 1976, it is the second youngest of the thirteen Dutch universities.
In 2021, 22,383 students studied at ...
in 2000. He is a member of the
U.S. National Academy of Sciences,
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
, and the
Royal Netherlands Academy of Arts and Sciences
The Royal Netherlands Academy of Arts and Sciences ( nl, Koninklijke Nederlandse Akademie van Wetenschappen, abbreviated: KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed ...
(since 1997). He is a fellow of the
American Academy of Arts and Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
.
He won a
Breakthrough Prize
The Breakthrough Prizes are a set of international awards bestowed in three categories by the Breakthrough Prize Board in recognition of scientific advances. The awards are part of several "Breakthrough" initiatives founded and funded by Yuri Mi ...
in 2017. In 2020 he received the
Canada Gairdner International Award
The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...
.
References
External links
Roeland Nusse Lab at Stanford University
{{DEFAULTSORT:Nusse, Roel
1950 births
Living people
Developmental biologists
Dutch biologists
Howard Hughes Medical Investigators
Members of the Royal Netherlands Academy of Arts and Sciences
Members of the United States National Academy of Sciences
Dutch molecular biologists
Scientists from Amsterdam
Stanford University School of Medicine faculty
University of Amsterdam alumni
Academic staff of the University of Amsterdam
University of California, San Francisco alumni