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Barlow's Disease (other)
Barlow's disease may refer to * Infantile scurvy Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, feeling tired and sore arms and legs. Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding ... (named after Sir Thomas Barlow (1845–1945)), who showed that the infantile scurvy is the same disease as adult scurvy. * Mitral valve prolapse (named after Dr. John Brereton Barlow (1924-2008)), who first described it in 1966. {{dab ...
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Scurvy
Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, feeling tired and sore arms and legs. Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding from the skin may occur. As scurvy worsens there can be poor wound healing, personality changes, and finally death from infection or bleeding. It takes at least a month of little to no vitamin C in the diet before symptoms occur. In modern times, scurvy occurs most commonly in people with mental disorders, unusual eating habits, alcoholism, and older people who live alone. Other risk factors include intestinal malabsorption and dialysis. While many animals produce their own vitamin C, humans and a few others do not. Vitamin C is required to make the building blocks for collagen. Diagnosis is typically based on physical signs, X-rays, and improvement after treatment. Treatment is with vitamin C supplements taken by mouth. Improvemen ...
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Sir Thomas Barlow, 1st Baronet
Sir Thomas Barlow, 1st Baronet, (4 November 1845 – 12 January 1945) was a British royal physician, known for his research on infantile scurvy. Life Barlow was the son of a Lancashire cotton manufacturer and Mayor of Bolton, James Barlow (1821–1887). The family were well known as philanthropists in their home village of Edgworth, Lancashire where they funded charities connected with the Methodist church including the Children's Home. He studied as an undergraduate at Manchester and London. University College London (UCL) Bachelor of Medicine (BM) in 1873 and Doctor of Medicine (MD) 1874. He became a registrar at Great Ormond Street Hospital, and later a physician and in 1899 a consultant. He was professor at the UCL from 1895 to 1907, initially of paediatrics and later of clinical medicine. In 1883, he showed that infantile scurvy was identical with adult scurvy. ''Barlow's disease'' – infantile scurvy – is named after him. He was Royal Physician to Queen ...
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Mitral Valve Prolapse
Mitral valve prolapse (MVP) is a valvular heart disease characterized by the displacement of an abnormally thickened mitral valve leaflet into the left atrium during systole. It is the primary form of myxomatous degeneration of the valve. There are various types of MVP, broadly classified as classic and nonclassic. In severe cases of classic MVP, complications include mitral regurgitation, infective endocarditis, congestive heart failure, and, in rare circumstances, cardiac arrest. The diagnosis of MVP depends upon echocardiography, which uses ultrasound to visualize the mitral valve. MVP is the most common valvular abnormality and is estimated to affect 2–3% of the population and 1 in 40 people might have it. The condition was first described by John Brereton Barlow in 1966. It was subsequently termed ''mitral valve prolapse'' by J. Michael Criley. Although mid-systolic click (sound of prolapsing mitral leaflet) and systolic murmur have been noticed earlier with stethoscope ...
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