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Balkan Nephropathy
Balkan endemic nephropathy (BEN) is a form of interstitial nephritis causing kidney failure. It was first identified in the 1920s among several small, discrete communities along the Danube River and its major tributaries, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Kosovo, Romania, and Bulgaria. It is caused by small long-term doses of aristolochic acid in the diet. The disease primarily affects people 30 to 60 years of age. Doses of the toxin are usually low and people moving to endemic areas typically develop the condition only when they have lived there for 10–20 years. People taking higher doses of aristolochic acid (as Chinese herbal supplements) have developed kidney failure after shorter durations of exposure.Stiborová, M., Arlt, V.M. & Schmeiser, H.H. Balkan endemic nephropathy: an update on its aetiology. Arch Toxicol 90, 2595–2615 (2016). https://doi.org/10.1007/s00204-016-1819-3 Signs and symptoms The patients are distinguished from those su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interstitial Nephritis
Interstitial nephritis, also known as tubulointerstitial nephritis, is inflammation of the area of the kidney known as the renal interstitium, which consists of a collection of cells, extracellular matrix, and fluid surrounding the renal tubules. In addition to providing a scaffolding support for the tubular architecture, the interstitium has been shown to participate in the fluid and electrolyte exchange as well as endocrine functions of the kidney. There are a variety of known factors that can provoke the inflammatory process within the renal interstitium, including pharmacologic, environmental, infectious and systemic disease contributors. The spectrum of disease presentation can range from an acute process to a chronic condition with progressive tubular cell damage and renal dysfunction. Signs and symptoms Interstitial nephritis may present with a variety of signs and symptoms, many of these nonspecific. Fever is the most common, occurring in 30-50% of patients, particularly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renal Pelvis
The renal pelvis or pelvis of the kidney is the funnel-like dilated part of the ureter in the kidney. It is formed by the covnvergence of the major calyces, acting as a funnel for urine flowing from the major calyces to the ureter. It has a mucous membrane and is covered with transitional epithelium and an underlying lamina propria of loose-to-dense connective tissue. The renal pelvis is situated within the renal sinus alongside the other structures of the renal sinus. The renal pelvis is the location of several kinds of kidney cancer and is affected by infection in pyelonephritis. Clinical significance The renal pelvis is the location of several kinds of kidney cancer and is affected by infection in pyelonephritis. A large "staghorn" kidney stone may block all or part of the renal pelvis. The size of the renal pelvis plays a major role in the grading of hydronephrosis. Normally, the anteroposterior diameter of the renal pelvis is less than 4 mm in fetuses up to 32 weeks ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yugoslavia
Yugoslavia (; sh-Latn-Cyrl, separator=" / ", Jugoslavija, Југославија ; sl, Jugoslavija ; mk, Југославија ;; rup, Iugoslavia; hu, Jugoszlávia; rue, label=Pannonian Rusyn, Югославия, translit=Juhoslavija; sk, Juhoslávia; ro, Iugoslavia; cs, Jugoslávie; it, Iugoslavia; tr, Yugoslavya; bg, Югославия, Yugoslaviya ) was a country in Southeast Europe and Central Europe for most of the 20th century. It came into existence after World War I in 1918 under the name of the ''Kingdom of Serbs, Croats and Slovenes'' by the merger of the provisional State of Slovenes, Croats and Serbs (which was formed from territories of the former Austria-Hungary) with the Kingdom of Serbia, and constituted the first union of the South Slavic people as a sovereign state, following centuries in which the region had been part of the Ottoman Empire and Austria-Hungary. Peter I of Serbia was its first sovereign. The kingdom gained international recog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karst
Karst is a topography formed from the dissolution of soluble rocks such as limestone, dolomite, and gypsum. It is characterized by underground drainage systems with sinkholes and caves. It has also been documented for more weathering-resistant rocks, such as quartzite, given the right conditions. Subterranean drainage may limit surface water, with few to no rivers or lakes. However, in regions where the dissolved bedrock is covered (perhaps by debris) or confined by one or more superimposed non-soluble rock strata, distinctive karst features may occur only at subsurface levels and can be totally missing above ground. The study of ''paleokarst'' (buried karst in the stratigraphic column) is important in petroleum geology because as much as 50% of the world's hydrocarbon reserves are hosted in carbonate rock, and much of this is found in porous karst systems. Etymology The English word ''karst'' was borrowed from German in the late 19th century, which entered German much earlier ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heavy Metal (chemistry)
upright=1.2, Crystals of osmium, a heavy metal nearly twice as dense as lead">lead.html" ;"title="osmium, a heavy metal nearly twice as dense as lead">osmium, a heavy metal nearly twice as dense as lead Heavy metals are generally defined as metals with relatively high density, densities, atomic weights, or atomic numbers. The criteria used, and whether metalloids are included, vary depending on the author and context. In metallurgy, for example, a heavy metal may be defined on the basis of density, whereas in physics the distinguishing criterion might be atomic number, while a chemist would likely be more concerned with chemical property, chemical behaviour. More specific definitions have been published, but none of these have been widely accepted. The definitions surveyed in this article encompass up to 96 out of the 118 known chemical elements; only mercury, lead and bismuth meet all of them. Despite this lack of agreement, the term (plural or singular) is widely used in s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sui Generis
''Sui generis'' ( , ) is a Latin phrase that means "of its/their own kind", "in a class by itself", therefore "unique". A number of disciplines use the term to refer to unique entities. These include: * Biology, for species that do not fit into a genus that includes other species * Creative arts, for artistic works that go beyond conventional genre boundaries * Law, when a special and unique interpretation of a case or authority is necessary ** Intellectual property rights, for types of works not falling under general copyright law but protected through separate statutes * Philosophy, to indicate an idea, an entity, or a reality that cannot be reduced to a lower concept or included in a higher concept Biology In the taxonomical structure "genus → species", a species is described as ''sui generis'' if its genus was created to classify it (i.e. its uniqueness at the time of classification merited the creation of a new genus, the sole member of which was initially the ''sui ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vratsa
Vratsa ( bg, Враца ) is the largest city in northwestern Bulgaria and the administrative and economic centre of the municipality of Vratsa and Vratsa district. It is located about 112 km north of Sofia, 40 km southeast of Montana. Situated at the foot of the Vrachanski Balkan, the town is near numerous caves, waterfalls and rock formations. The most famous of them are the Ledenika Cave, Skaklya Waterfall and the Vratsata Pass. The Vratsa History Museum holds the Rogozen treasure, which is the largest Thracian treasure. Botev Days are held annually in the city, culminating in the rally-dawn on June 1, held at Hristo Botev Square, as well as the national worship on June 2 at Mount Okolchitsa. Vratsa's motto is "A city like the Balkan - ancient and young". Name The name comes from the Vratsata Pass nearby, and derives from the Slavic word ''vrata'' ("gate") + the Slavic diminutive placename suffix ''-itsa'', "little gate", used to translate the Latin name ''Valv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumorigenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer disrupt these orderly processes by interfering with the programming regulating the processes, upsetting the normal balance between proliferation and cell death. This results in uncontrolled cell division and the evolution of those cells by natural selection in the body. Only certain mutations lead to cancer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uroepithelial
Transitional epithelium also known as urothelium is a type of stratified epithelium. Transitional epithelium is a type of tissue that changes shape in response to stretching (stretchable epithelium). The transitional epithelium usually appears cuboidal when relaxed and squamous when stretched. This tissue consists of multiple layers of epithelial cells which can contract and expand in order to adapt to the degree of distension needed. Transitional epithelium lines the organs of the urinary system and is known here as urothelium. The bladder for example has a need for great distension. Structure The appearance of transitional epithelium differs according to its cell layer. Cells of the basal layer are cuboidal (cube-shaped), or columnar (column-shaped), while the cells of the superficial layer vary in appearance depending on the degree of distension. These cells appear to be cuboidal with a domed apex when the organ or the tube in which they reside is not stretched. When the orga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Traditional Chinese Medicine
Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action. Medicine in traditional China encompassed a range of sometimes competing health and healing practices, folk beliefs, literati theory and Confucian philosophy, herbal remedies, food, diet, exercise, medical specializations, and schools of thought. In the early twentieth century, Chinese cultural and political modernizers worked to eliminate traditional practices as backward and unscientific. Traditional practitioners then selected elements of philosophy and practice and organized them into what they called "Chinese medicine" (''Zhongyi''). In the 1950s, the Chinese government sponsored the integration of Chinese and Western medicine, and in the Great Proletarian Cultural Revolution of the 1960s, promoted Chinese medicine as inexpensive a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herbal Remedies
Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. With worldwide research into pharmacology, some herbal medicines have been translated into modern remedies, such as the anti-malarial group of drugs called artemisinin isolated from ''Artemisia annua'', a herb that was known in Chinese medicine to treat fever. There is limited scientific evidence for the safety and efficacy of plants used in 21st century herbalism, which generally does not provide standards for purity or dosage. The scope of herbal medicine commonly includes fungal and bee products, as well as minerals, shells and certain animal parts. Herbal medicine is also called phytomedicine or phytotherapy. Paraherbalism describes alternative and pseudoscientific practices of using unrefined plant or animal extracts as unproven medicines or health-promoting agents. Paraherbalism relies on the belief that preserving various substances ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aristolochia Clematitis
''Aristolochia clematitis'', the (European) birthwort, is a twining herbaceous plant in the family Aristolochiaceae, which is native to Europe. The leaves are heart shaped and the flowers are pale yellow and tubular in form. The plant seeks light by ascending the stems of surrounding plants. Toxicity It was formerly used as a medicinal plant, though it is poisonous, and is now occasionally found established outside of its native range as a relic of cultivation. It is now thought to be the cause of thousands of kidney failures in Romania, Bulgaria, Serbia, Bosnia and Herzegovina and Croatia. The initial hypothesis that seeds from the plant were unintentionally consumed through contaminated flour has come to be questioned. Urinary tract malignancies among those who have consumed the plant are also reported. The link between kidney failure and aristolochic acid, which the plant contains, was discovered after a clinic for obesity in Belgium used herbal products based on another pl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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