''Aristolochia clematitis'', the (European) birthwort, is a twining

herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of t ...

plant in the family

Aristolochiaceae The Aristolochiaceae () are a family, the birthwort family, of flowering plants with seven genera and about 400 known species belonging to the order Piperales. The type genus is ''Aristolochia'' L. Description They are mostly perennial, he ...

, which is native to Europe. The leaves are heart shaped and the flowers are pale yellow and tubular in form. The plant seeks light by ascending the stems of surrounding plants.

Toxicity

It was formerly used as a medicinal plant, though it is

poisonous Poison is a chemical substance that has a detrimental effect to life. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broa ...

, and is now occasionally found established outside of its native range as a relic of cultivation. It is now thought to be the cause of thousands of kidney failures in

Romania Romania ( ; ro, România ) is a country located at the crossroads of Central Europe, Central, Eastern Europe, Eastern, and Southeast Europe, Southeastern Europe. It borders Bulgaria to the south, Ukraine to the north, Hungary to the west, S ...

Bulgaria Bulgaria (; bg, България, Bǎlgariya), officially the Republic of Bulgaria,, ) is a country in Southeast Europe. It is situated on the eastern flank of the Balkans, and is bordered by Romania to the north, Serbia and North Macedon ...

Serbia Serbia (, ; Serbian language, Serbian: , , ), officially the Republic of Serbia (Serbian language, Serbian: , , ), is a landlocked country in Southeast Europe, Southeastern and Central Europe, situated at the crossroads of the Pannonian Bas ...

Bosnia and Herzegovina Bosnia and Herzegovina ( sh, / , ), abbreviated BiH () or B&H, sometimes called Bosnia–Herzegovina and often known informally as Bosnia, is a country at the crossroads of south and southeast Europe, located in the Balkans. Bosnia and H ...

and

Croatia , image_flag = Flag of Croatia.svg , image_coat = Coat of arms of Croatia.svg , anthem = "Lijepa naša domovino"("Our Beautiful Homeland") , image_map = , map_caption = , capit ...

. The initial hypothesis that seeds from the plant were unintentionally consumed through contaminated flour has come to be questioned. Urinary tract malignancies among those who have consumed the plant are also reported. The link between

kidney failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...

and aristolochic acid, which the plant contains, was discovered after a clinic for obesity in

Belgium Belgium, ; french: Belgique ; german: Belgien officially the Kingdom of Belgium, is a country in Northwestern Europe. The country is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeast, France to th ...

used herbal products based on another plant of the same genus as a diuretic. After a few months, some of the patients experienced kidney failure.

References

clematitis Medicinal plants of Europe Plants described in 1753 Taxa named by Carl Linnaeus {{Piperales-stub

Toxicity

See also

References