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Bad Pharma
''Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients'' is a book by the British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products.Luisa Dillner"Bad Pharma by Ben Goldacre – review" ''The Guardian'', 17 October 2012. It was published in the UK in September 2012 by the Fourth Estate imprint of HarperCollins, and in the United States in February 2013 by Faber and Faber. Goldacre argues in the book that "the whole edifice of medicine is broken", because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ben Goldacre
Ben Michael Goldacre (born 20 May 1974) is a British physician, academic and science writer. He is the first Bennett Professor of Evidence-Based Medicine and director of the Bennett Institute for Applied Data Science at the University of Oxford. He is a founder of the AllTrials campaign and OpenTrials to require open science practices in clinical trials. Goldacre is known in particular for his ''Bad Science'' column in ''The Guardian'', which he wrote between 2003 and 2011, and is the author of four books: '' Bad Science'' (2008), a critique of irrationality and certain forms of alternative medicine; '' Bad Pharma'' (2012), an examination of the pharmaceutical industry, its publishing and marketing practices, and its relationship with the medical profession; ''I Think You'll Find It's a Bit More Complicated Than That'', a collection of his journalism; and ''Statins'', about evidence-based medicine. Goldacre frequently delivers free talks about bad science; he describes himself ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ben Goldacre TAM London 2009 (2)
Ben is frequently used as a shortened version of the given names Benjamin, Benedict, Bennett or Benson, and is also a given name in its own right. Ben (in he, בֶּן, ''son of'') forms part of Hebrew surnames, e.g. Abraham ben Abraham ( he, אברהם בן אברהם). Bar-, "son of" in Aramaic, is also seen, e.g. Simon bar Kokhba ( he, שמעון בר כוכבא). Ben meaning "son of" is also found in Arabic as ''Ben'' (dialectal Arabic) or ''bin'' (بن), ''Ibn''/''ebn'' (ابن). People with the given name * Ben Adams (born 1981), member of the British boy band A1 * Ben Affleck (born 1972), American Academy Award-winning actor and screenwriter * Ben Ashkenazy (born 1968/69), American billionaire real estate developer * Ben Askren (born 1984), American sport wrestler and mixed martial artist * Ben Banogu (born 1996), American football player * Ben Barba (born 1989), Australian rugby player * Ben Barnes (other), multiple people * Ben Bartch (born 1998), A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Publication Bias
In published academic research, publication bias occurs when the outcome of an experiment or research study biases the decision to publish or otherwise distribute it. Publishing only results that show a significant finding disturbs the balance of findings in favor of positive results. The study of publication bias is an important topic in metascience. Despite similar quality of execution and design, papers with statistically significant results are three times more likely to be published than those with null results. This unduly motivates researchers to manipulate their practices to ensure statistically significant results, such as by data dredging. Many factors contribute to publication bias. For instance, once a scientific finding is well established, it may become newsworthy to publish reliable papers that fail to reject the null hypothesis. Most commonly, investigators simply decline to submit results, leading to non-response bias. Investigators may also assume they made a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholesterol
Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membranes. When chemically isolated, it is a yellowish crystalline solid. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as '' Mycoplasma'', which require cholesterol for growth. François Poulletier de la Salle first identified cholesterol in solid form in gallstones in 1769. However, it was not until 1815 that chemist Michel Eugène Chevreul named the compound "cholesterine". Etymology The word "cholesterol" comes from the Ancient Greek ''chole-'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statin
Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease. They are the most common cholesterol-lowering drugs. Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and coronary heart disease via the mechanisms described by the lipid hypothesis. Statins are effective in lowering LDL cholesterol and so are widely used for primary prevention in people at high risk of cardiovascular disease, as well as in secondary prevention for those who have developed cardiovascular disease. Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormal blood levels of liver enzymes. Additionally, they have rare but severe adverse effects, particularly muscle damage. They inhibit the enzyme HMG-CoA reductase which plays a central role in the production of cholesterol. High cholester ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLOS Medicine
''PLOS Medicine'' (formerly styled ''PLoS Medicine'') is a peer-reviewed weekly medical journal covering the full spectrum of the medical sciences. It began operation on October 19, 2004, as the second journal of the Public Library of Science (PLOS), a non-profit open access publisher. All content in ''PLOS Medicine'' is published under the Creative Commons "by-attribution" license. To fund the journal, the publication's business model requires in most cases that authors pay publication fees. The journal was published online and in a printed format until 2005 and is now only published online. The journal's acting chief editor is Clare Stone, who replaced the previous chief editor, Larry Peiperl, in 2018. Aims and scope The journal's initial aim was to provide an open-access alternative to existing top tier journals such as ''The New England Journal of Medicine'' and ''The Lancet'' and has concentrated on publishing papers on diseases that take the greatest toll on health globa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Service Journal
''Health Service Journal'' (''HSJ'') is a news service that covers policy and management in the National Health Service (NHS) in England. History The '' Poor Law Officers' Journal'' was established in 1892. In 1930, it changed its name after the passing of the Local Government Act 1929 to the ''Public Assistance Journal and Health and Hospital Review'', then in 1948, it became the ''Hospital and Social Service Journal''. In 1963, it became the ''Hospital and Social Service Review'', in 1973, the ''Health and Social Service Journal'', and the ''Health Service Journal'' in 1986. It was part of a group of business-to-business titles published by the Emap group, which was purchased by the Guardian Media Group in 2008. /sup> In 2008, it had an average circulation of almost 18,000 copies, most of which were by subscription. It was part of a group of business-to-business titles published by the Emap group, which was purchased by the Guardian Media Group in 2008. In October 2015, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo Effect
A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like Saline (medicine), saline), sham surgery, and other procedures. In general, placebos can affect how patients perceive their condition and encourage the body's chemical processes for relieving pain and a few other symptoms, but have no impact on the disease itself. Improvements that patients experience after being treated with a placebo can also be due to unrelated factors, such as regression to the mean (a statistical effect where an unusually high or low measurement is likely to be followed by a less extreme one). The use of placebos in clinical medicine raises ethical concerns, especially if they are disguised as an active treatment, as this introduces dishonesty into the doctor–patient relationship and bypasses informed consent. While it was once assumed that this deception was necessary for placebos to have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AIDS Denialism
HIV/AIDS denialism is the belief, despite conclusive evidence to the contrary, that the human immunodeficiency virus (HIV) does not cause acquired immune deficiency syndrome (AIDS). Some of its proponents reject the existence of HIV, while others accept that HIV exists but argue that it is a harmless passenger virus and not the cause of AIDS. Insofar as they acknowledge AIDS as a real disease, they attribute it to some combination of sexual behavior, recreational drugs, malnutrition, poor sanitation, haemophilia, or the effects of the medications used to treat HIV infection (antiretrovirals). The scientific consensus is that the evidence showing HIV to be the cause of AIDS is conclusive and that HIV/AIDS denialist claims are pseudoscience based on conspiracy theories, faulty reasoning, cherry picking, and misrepresentation of mainly outdated scientific data. With the rejection of these arguments by the scientific community, HIV/AIDS denialist material is now targeted at less ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MMR Vaccine Controversy
Claims of a link between the MMR vaccine and autism have been extensively investigated and found to be false. The link was first suggested in the early 1990s and came to public notice largely as a result of the 1998 ''Lancet'' MMR autism fraud, characterised as "perhaps the most damaging medical hoax of the last 100 years". The fraudulent research paper authored by Andrew Wakefield and published in ''The Lancet'' claimed to link the vaccine to colitis and autism spectrum disorders. The paper was retracted in 2010 but is still cited by anti-vaccinationists. The claims in the paper were widely reported, leading to a sharp drop in vaccination rates in the UK and Ireland. Promotion of the claimed link, which continues in anti-vaccination propaganda despite being refuted, has led to an increase in the incidence of measles and mumps, resulting in deaths and serious permanent injuries. Following the initial claims in 1998, multiple large epidemiological studies were undertaken. Rev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Critical Thinking
Critical thinking is the analysis of available facts, evidence, observations, and arguments to form a judgement. The subject is complex; several different definitions exist, which generally include the rational, skeptical, and unbiased analysis or evaluation of factual evidence. Critical thinking is self-directed, self-disciplined, self- monitored, and self- corrective thinking. It presupposes assent to rigorous standards of excellence and mindful command of their use. It entails effective communication and problem-solving abilities as well as a commitment to overcome native egocentrism and sociocentrism. History The earliest records of critical thinking are the teachings of Socrates recorded by Plato. These included a part in Plato's early dialogues, where Socrates engages with one or more interlocutors on the issue of ethics such as question whether it was right for Socrates to escape from prison. The philosopher considered and reflected on this question and came to the conc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London School Of Hygiene And Tropical Medicine
The London School of Hygiene and Tropical Medicine (LSHTM) is a public research university in Bloomsbury, central London, and a member institution of the University of London that specialises in public health and tropical medicine. The institution was founded in 1899 by Sir Patrick Manson, after a donation from the Indian Parsi philanthropist B. D. Petit. Since its foundation it has become one of the most highly placed institutions in global rankings in the fields of public health and infectious diseases. The annual income of the institution for 2020–21 was £244.2 million, of which £167.6 million was from research grants and contracts, with expenditures totalling £235.2 million during the same period. History Origins (1899–1913) The school was founded on October 2, 1899, by Sir Patrick Manson as the London School of Tropical Medicine after the Parsi philanthropist Bomanjee Dinshaw Petit made a donation of £6,666. It was initially located at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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