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BRI1202-07
Brassinosteroid insensitive 1 (BRI1) is the major receptor of the plant hormone brassinosteroid. It plays very important roles in plant development, especially in the control of cell elongation and for the tolerance of environmental stresses. BRI1 enhances cell elongation, promotes pollen development, controls vasculature development and promotes chilling and freezing tolerance. BRI1 is one of the most well studied hormone receptors and it acts a model for the study of membrane-bound receptors in plants. Structure BRI1 is an integral membrane protein. On the extracellular side of the membrane lies a series of 25 leucine-rich repeats (LRRs). The LRR domain forms a horseshoe shape. An atypical LRR within this domain acts as the brassinosteroid binding site. Next to the LRR domain there is a single-pass transmembrane section. The intracellular domain of BRI1 functions as a kinase and it is this domain triggers the phosphorylation cascade that results in changes of gene expre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinase
In biochemistry, a kinase () is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule donates a phosphate group to the substrate molecule. This transesterification produces a phosphorylated substrate and ADP. Conversely, it is referred to as dephosphorylation when the phosphorylated substrate donates a phosphate group and ADP gains a phosphate group (producing a dephosphorylated substrate and the high energy molecule of ATP). These two processes, phosphorylation and dephosphorylation, occur four times during glycolysis. Kinases are part of the larger family of phosphotransferases. Kinases should not be confused with phosphorylases, which catalyze the addition of inorganic phosphate groups to an acceptor, nor with phosphatases, which remove phosphate groups (dephosphorylation). The phosphorylation state of a molecule, whet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flagellin
Flagellin is a globular protein that arranges itself in a hollow cylinder to form the filament in a bacterial flagellum. It has a mass of about 30,000 to 60,000 daltons. Flagellin is the principal component of bacterial flagella, and is present in large amounts on nearly all flagellated bacteria. Structure The structure of flagellin is responsible for the helical shape of the flagellar filament, which is important for its proper function. It is transported through the center of the filament to the tip where it polymerases spontaneously into a part of the filament. It is unfolded by the FliS () flagellar secretion chaperone during transport. The filament is made up of eleven smaller "protofilaments", nine of which contains flagellin in the L-type shape and the other two in the R-type shape. The helical N- and C-termini of flagellin form the inner core of the flagellin protein, and is responsible for flagellin's ability to polymerize into a filament. The middle residues make ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FLS2
''FLS'' genes have been discovered to be involved in flagellin reception of bacteria. FLS1 was the original gene discovered shown to correspond with a specific ecotype within ''Arabidopsis thaliana''. Even so, further studies have shown a second FLS gene known as ''FLS2'' that is also associated with flagellin reception. ''FLS2'' and FLS1 are different genes with different responsibilities, but are related genetically. ''FLS2'' has a specific focus in plant defense and is involved in promoting the MAP kinase cascade. Mutations in the ''FLS2'' gene can cause bacterial infection by lack of response to flg22. Therefore,''FLS2''’s primary focus is association with flg22 while its secondary focus is the involvement of promoting the MAP kinase cascade in plant defense. ''FLS2'' and its similarities to receptor-like kinases HOLAKHEASEN ''FLS2'' is considered a receptor like kinase (RLK). RLKs are very similar to tyrosine kinases but different in the fact that tyrosine kinases are prese ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homology (biology)
In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of primates, the front flippers of whales and the forelegs of four-legged vertebrates like dogs and crocodiles are all derived from the same ancestral tetrapod structure. Evolutionary biology explains homologous structures adapted to different purposes as the result of descent with modification from a common ancestor. The term was first applied to biology in a non-evolutionary context by the anatomist Richard Owen in 1843. Homology was later explained by Charles Darwin's theory of evolution in 1859, but had been observed before this, from Aristotle onwards, and it was explicitly analysed by Pierre Belon in 1555. In developmental biology, organs that developed in the embryo in the same manner and from similar origins, such as from matching p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arabidopsis Thaliana
''Arabidopsis thaliana'', the thale cress, mouse-ear cress or arabidopsis, is a small flowering plant native to Eurasia and Africa. ''A. thaliana'' is considered a weed; it is found along the shoulders of roads and in disturbed land. A winter annual with a relatively short lifecycle, ''A. thaliana'' is a popular model organism in plant biology and genetics. For a complex multicellular eukaryote, ''A. thaliana'' has a relatively small genome around 135 mega base pairs. It was the first plant to have its genome sequenced, and is a popular tool for understanding the molecular biology of many plant traits, including flower development and light sensing. Description ''Arabidopsis thaliana'' is an annual (rarely biennial) plant, usually growing to 20–25 cm tall. The leaves form a rosette at the base of the plant, with a few leaves also on the flowering stem. The basal leaves are green to slightly purplish in color, 1.5–5 cm long, and 2–10 mm broad, with an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brassinosteroid Signalling Kinase
Brassinosteroids (BRs or less commonly BS) are a class of polyhydroxysteroids that have been recognized as a sixth class of plant hormones and may have utility as an anticancer drug for endocrine-responsive cancers to induce apoptosis and inhibit growth. These brassinosteroids were first explored during the 70s, when Mitchell et al. reported promotion in stem elongation and cell division by the treatment of organic extracts of rapeseed (''Brassica napus'') pollen. Brassinolide was the first isolated brassinosteroid in 1979, when pollen from ''Brassica napus'' was shown to promote stem elongation and cell divisions, and the biologically active molecule was isolated. The yield of brassinosteroids from 230 kg of ''Brassica napus'' pollen was only 10 mg. Since their discovery, over 70 BR compounds have been isolated from plants. Biosynthesis The BR is biosynthesised from campesterol. The biosynthetic pathway was elucidated by Japanese researchers and later shown to be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License. Protein phosphorylation often activates (or deactivates) many enzymes. Glucose Phosphorylation of sugars is often the first stage in their catabolism. Phosphorylation allows cells to accumulate sugars because the phosphate group prevents the molecules from diffusing back across their transporter. Phosphorylation of glucose is a key reaction in sugar metabolism. The chemical equation for the conversion of D-glucose to D-glucose-6-phosphate in the first step of glycolysis is given by :D-glucose + ATP → D-glucose-6-phosphate + ADP : ΔG° = −16.7 kJ/mol (° indicates measurement at standard condition) Hepatic cells are freely permeable to glucose, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BRI1-associated Receptor Kinase 1
BRI1-associated receptor kinase 1 (BAK1- also known as somatic embryogenesis receptor kinase 3 or SERK3) is an important plant protein that has diverse functions in plant development. Structure BAK1 belongs to a large group of plant proteins known as the Leucine-rich repeat receptor kinases (LRR-RKs). In the model plant species ''Arabidopsis thaliana'', BAK1 and 4 other closely related proteins form a sub-group within the LRR-RK family, known as the somatic embryogenesis receptor kinases (SERKs). All 5 SERKs are transmembrane proteins. They consist of an extracellular domain, a single transmembrane pass and an intracellular domain. The extracellular domain is composed of several leucine rich repeats, and the intracellular domain functions as a protein kinase. BAK1 is thought to interact with many other LRR-RKs and the signalling output of BAK1 is dependent on its binding partner Roles in plant development Brassinosteroid signalling BAK1 was initially identified for it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
