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Arias-Stella Phenomenon
Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. Arias-Stella reaction is due to progesterone primarily. Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer. Significance It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy. Diagnosis It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions. Five subtypes are recognized: #Minimal atypia. #Early secretory pattern. #Secretory or hypersecretory pattern. #Regenerative, proliferative or nonsecretory pattern. #Monstrous cell pattern. History It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954. See also * Choriocarcinoma * Chorioangioma * Herpes * Nuclear atypia Nuc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromatin
Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin. The primary protein components of chromatin are histones. An octamer of two sets of four histone cores (Histone H2A, Histone H2B, Histone H3, and Histone H4) bind to DNA and function as "anchors" around which the strands are wound.Maeshima, K., Ide, S., & Babokhov, M. (2019). Dynamic chromatin organization without the 30-nm fiber. ''Current opinion in cell biology, 58,'' 95–104. https://doi.o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Atypia
Nuclear atypia refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic. Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy. See also * Arias-Stella reaction *NC ratio The nuclear-cytoplasmic ratio (also variously known as the nucleus:cytoplasm ratio, nucleus-cytoplasm ratio, N:C ratio, or N/C) is a measurement used in cell biology. It is a ratio of the size (i.e., volume) of the cell nucleus, nucleus of a cell ... * Nuclear pleomorphism {{pathology-stub Pathology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herpes
Herpes simplex is a viral infection caused by the herpes simplex virus. Infections are categorized based on the part of the body infected. Oral herpes involves the face or mouth. It may result in small blisters in groups often called cold sores or fever blisters or may just cause a sore throat. Genital herpes, often simply known as herpes, involves the genitalia. It may have minimal symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling or shooting pains may occur before the blisters appear. Herpes cycles between periods of active disease followed by periods without symptoms. The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches. Over time, episodes of active disease decrease in frequency and severity. Herpetic whitlow typically involves the fingers or thumb. Herpes simplex keratitis involves the eye. Herpesviral encephalitis involves the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chorioangioma
Chorioangioma, or chorangioma, is a benign tumor of placenta. It is a hamartoma-like growth in the placenta consisting of blood vessels, and is seen in approximately 0.5 to 1% pregnancies. It is mostly diagnosed ultrasonically in the second trimester of pregnancy. Large chorioangiomas are known to cause complications in pregnancy, while the smaller ones are asymptomatic. Presentation Most chorangiomas are not clinically significant, i.e. they do not have an adverse effect on placental function. Complications Large (greater than 4 or 5 cm.) or multiple chorioangiomas may lead to complication. The complications are polyhydramnios, preterm labour, hemolytic anemia, fetal cardiomegaly, fetal thrombocytopenia, intrauterine growth retardation, preeclampsia, abruption of placenta and congenital anomalies. Pathogenesis The origin of chorioangioma is from primitive chorionic mesenchyme. It develops when the blood vessels and stroma undergo rapid proliferation independent of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Choriocarcinoma
Choriocarcinoma is a malignant, trophoblastic cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs. It belongs to the malignant end of the spectrum in gestational trophoblastic disease (GTD). It is also classified as a germ cell tumor and may arise in the testis or ovary. Signs and symptoms * increased quantitative chorionic gonadotropin (the "pregnancy hormone") levels * vaginal bleeding * shortness of breath * hemoptysis (coughing up blood) * chest pain * chest X-ray shows multiple infiltrates of various shapes in both lungs * presents in males as a testicular cancer, sometimes with skin hyperpigmentation (from excess chorionic gonadotropin cross reacting with the alpha MSH receptor), gynecomastia, and weight loss (from excess chorionic gonadotropin cross reacting with the LH, FSH, and TSH receptor) in males * can present with decreased thyroid-stimulating hormone (TSH) due to hyperthyroidism. Cause Choriocarcinoma of the placenta dur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathologist
Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue (biology), tissue, human cell, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be "Pathophysiology, pathophysiologies"), and the affix ''pathy'' is sometimes used to indicate a state of disease ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peruvian
Peruvians ( es, peruanos) are the citizens of Peru. There were Andean and coastal ancient civilizations like Caral, which inhabited what is now Peruvian territory for several millennia before the Spanish conquest in the 16th century; Peruvian population decreased from an estimated 5–9 million in the 1520s to around 600,000 in 1620 mainly because of infectious diseases carried by the Spanish Empire, Spanish. Spaniards and Afro-Peruvians, Africans arrived in large numbers in 1532 under colonial rule, mixing widely with each other and with Native Peruvians. During the Republic, there has been a gradual immigration of European people (especially from Spain and Italy, and in a less extent from Germany, France, Croatia, and the British Isles). Chinese people, Chinese and Japanese people, Japanese arrived in large numbers at the end of the 19th century. With 31.2 million inhabitants according to the 2017 Peru Census, 2017 Census, Peru is the List of South American countries by popula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Javier Arias Stella
Javier Arias Stella (August 2, 1924 – February 25, 2020) was a Peruvian pathologist, politician, diplomat, academic, and lecturer who variously served as Minister of Public Health of Peru (1963-1965, 1967-1968), Minister of Foreign Relations of Peru (1980-1983), and President of the United Nations Security Council (March 1984, April 1985), the former two positions having been served under Peruvian president Fernando Belaúnde Terry. He was best known in medical circles for having discovered the eponymously-named Arias-Stella reaction. Education Arias Stella's undergraduate studies were done first at the San Marcos National University's School of Science in Peru from 1942 to 1944 and then at the Faculty of Medicine from 1945 to 1951, from which he earned his bachelor's in 1951. His doctorate was also earned from that faculty in 1959. Research Arias-Stella reaction Arias Stella found that a reaction previously thought of as a cancer in the endometrium was rather a normal rea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Membrane
The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material. The nuclear envelope consists of two lipid bilayer membranes: an inner nuclear membrane and an outer nuclear membrane. The space between the membranes is called the perinuclear space. It is usually about 10–50 nm wide. The outer nuclear membrane is continuous with the endoplasmic reticulum membrane. The nuclear envelope has many nuclear pores that allow materials to move between the cytosol and the nucleus. Intermediate filament proteins called lamins form a structure called the nuclear lamina on the inner aspect of the inner nuclear membrane and give structural support to the nucleus. Structure The nuclear envelope is made up of two lipid bilayer membranes, an inner nuclear membrane and an outer nuclear membrane. These membranes are connected to each other by nuclear pores. Two sets of in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benign
Malignancy () is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous benign tumor, ''benign'' tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties. Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes. Cancers usually show tumour heterogeneity, containing multiple subclones. They also frequently have reduced expression of DNA repair enzymes due to Epigenetics#DNA repair epigenetics in cancer, epigenetic methylation of DNA repair genes or altered MicroRNA#DNA repair and cancer, micr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Nucleus
The cell nucleus (pl. nuclei; from Latin or , meaning ''kernel'' or ''seed'') is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support. The cell nucleus contains nearly all of the cell's genome. Nuclear DNA is often organized into multiple chromosomes – long stands of DNA dotted with various proteins, such as histones, that protect and organize the DNA. The genes within these chromosomes are structured in such a way to promote cell function. The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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