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Amino Acid Permease
Amino acid permeases are membrane permeases involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related. These proteins contain 12 transmembrane segments. See also *Amino acid transporter Human proteins containing this domain CIP1; SLC12A1; SLC12A2; SLC12A3; SLC12A4; SLC12A5; SLC12A6; SLC12A7; SLC12A8; SLC12A9; SLC7A1; SLC7A10; SLC7A11; SLC7A13; SLC7A14; SLC7A2; SLC7A3; SLC7A4; SLC7A5; SLC7A6; SLC7A7; SLC7A8; SLC7A9 b(0,+)-type amino acid transporter 1, also known as b(0,+)AT1, is a protein which in humans is encoded by the ''SLC7A9'' gene. Function This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This pro ...; References Protein domains Protein families Membrane proteins {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Permease
The permeases are membrane transport proteins, a class of multipass transmembrane proteins that allow the diffusion of a specific molecule in or out of the cell in the direction of a concentration gradient, a form of facilitated diffusion. The permease binding is first step of translocation. LacY protein from Escherichia coli is an example of a permease. See also * Lactose permease * Beta-galactoside permease It was originally discovered in the 1930s by Joy Adames. It is a transporter protein that helps in various aspects of cellular life including DNA replication, translation of RNA, and diffusion. * Amino acid permease Amino acid permeases are membrane permeases involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related. These proteins contain 12 transmembrane segments. See also *Amino acid tra ... A permease (porter) is a protein or protein complex that catalyzes a vectorial reaction, irrespective of whether ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A11
Cystine/glutamate transporter is an antiporter that in humans is encoded by the ''SLC7A11'' gene. The SLC7A11 gene codes for a sodium-independent cystine-glutamate antiporter that is chloride dependent, known as system Xc- or xCT. It regulates synaptic activity by stimulating extrasynaptic receptors and performs nonvesicular glutamate release. This gene is highly expressed by astrocytes and couples the uptake of one molecule of cystine with the release of one molecule of glutamate. The dimer cystine gets taken up by glial cells and the monomer of cystine, cysteine, is taken up by neurons. The expression of Xc- was detected throughout the brain with higher expression found in the basolateral amygdala, the Retina and the prefrontal cortex. The inhibition of system Xc- has been found to alter a number of behaviors, which suggests that it plays a key role in excitatory signaling. Structure SLC7A11 is a member of a heterodimeric Na+-independent anionic amino acid transport sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Domains
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. In general, domains vary in length from between about 50 amino acids up to 250 amino acids in length. The shortest domains, such as zinc fingers, are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be "swapped" by genetic engineering between one protein and another to make chimeric proteins. Background The concept of the domain was first proposed in 1973 by Wetlaufer after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A9
b(0,+)-type amino acid transporter 1, also known as b(0,+)AT1, is a protein which in humans is encoded by the ''SLC7A9'' gene. Function This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. The protein associates with the protein coded for by SLC3A1. Clinical significance Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. See also * Heterodimeric amino acid transporter Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membrane The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and his ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A8
Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the ''SLC7A8'' gene. See also * Heterodimeric amino acid transporter Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membrane The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historical ... * Solute carrier family References Further reading * * * * * * * * * * * Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A7
Y+L amino acid transporter 1 is a protein that in humans is encoded by the ''SLC7A7'' gene. Interactions SLC7A7 has been shown to interact with SLC3A2. See also * Heterodimeric amino acid transporter * Solute carrier family * Lysinuric protein intolerance Lysinuric protein intolerance (LPI) is an autosomal recessive metabolic disorder affecting amino acid transport. About 140 patients have been reported, almost half of them of Finnish origin. Individuals from Japan, Italy, Morocco and North Afri ... References Further reading * * * * * * * * * * * * * * External links GeneReviews/NCBI/NIH/UW entry on Lysinuric Protein Intolerance Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A6
Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the ''SLC7A6'' gene. See also * Heterodimeric amino acid transporter Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membrane The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historical ... References Further reading * * * * * Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A5
Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the ''SLC7A5'' gene. See also * Heterodimeric amino acid transporter Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membrane The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historical ... References Further reading * * * * * * * * * * * * * * * * * * * * Solute carrier family {{gene-16-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A4
Cationic amino acid transporter 4 is a protein that in humans is encoded by the ''SLC7A4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... See also * References Further reading * * * * * * * Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A3
Cationic amino acid transporter 3 is a protein that in humans is encoded by the ''SLC7A3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids. upplied by OMIMref name="entrez"/> See also * Solute carrier family References Further reading * * * * * * * * * Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A2
Cationic amino acid transporter 2 is a protein that in humans is encoded by the ''SLC7A2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... See also * References Further reading * * * * * * * Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC7A14
Solute carrier family 7, member 14 is a protein that in humans is encoded by the SLC7A14 gene. This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissuee, photoreceptor cells, hair cells and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. The gene is also highly expressed in all vertebrate hair cells. In the mammalian inner ear, this gene is expressed in neonatal inner and outer hair cells during development and becomes specifically expressed in inner hair cells in adult animals , Reference 4.Mutations in this gene are associated with autosomal recessive retinitis pigmentosa and hearing loss in the form of auditor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
