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Alvin J. Siteman Cancer Center
The Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is a cancer treatment, research and education institution with six locations in the St. Louis area. Siteman is the only cancer center in Missouri and within 240 miles of St. Louis to be designated a Comprehensive Cancer Center by the National Cancer Institute (NCI). Siteman is also the only area member of the National Comprehensive Cancer Network, a nonprofit alliance of 32 cancer centers dedicated to improving the quality and effectiveness of cancer care. In 2020 and 2015, Siteman received the highest rating possible - exceptional - by the NCI for cancer research. At Siteman's reviews leading to the ratings, researchers presented their findings in genomics, cancer imaging, cancer prevention and disparities, and the use of the body's immune system to fight cancer. In 2022, Siteman was named the No. 10 U.S. cancer center by U.S. News & World Report. The recognition is part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elaine Mardis
Elaine R. Mardis (born September 28, 1962) is the co-executive director of the Institute for Genomic Medicine at Nationwide Children's Hospital, where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine. She also is professor of pediatrics at the Ohio State University College of Medicine. Mardis’s research focuses on the genomic characterization of cancer and its implications for cancer medicine. She was part of the team that reported the first next-generation-based sequencing of a whole cancer genome, and participated extensively in The Cancer Genome Atlas (TCGA) and the Pediatric Cancer Genome Project (PCGP). Biography Mardis was born in North Platte, Nebraska. She gained a passion for science at an early age, and credits her father, a chemistry professor for more than 30 years, for nurturing this passion. She received her undergraduate degree in Zoology from the University of Oklahoma in 1984. During her senior year she took a course in biochemistr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Graham Colditz
Graham Andrew Colditz MD, DrPH (born 1 November 1954) is an Australian chronic disease epidemiologist. He is the inaugural Niess-Gain Professor at Washington University School of Medicine, where he is associate director for Prevention and Control at the Alvin J. Siteman Cancer Center. He directs the Master of Population Health Science at Washington University School of Medicine. During medical training he was excited by the potential for prevention of chronic diseases. With encouragement from mentors he pursued training in the US as it was routine for academics in Australia to obtain overseas training at that time. He is internationally recognized for leadership in cancer prevention, and is often interviewed by media for input on this topic. With members of Cancer Prevention and Control at Siteman, he blogs on issues relating to cancer prevention and screening. According to Google Scholar statistics, Colditz has a h-index of more than 300. Birth and education Colditz was born in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growing Up Today Study
The Growing Up Today Study (GUTS) is an ongoing collaborative research project between researchers at the Harvard T.H. Chan School of Public Health and Brigham and Women's Hospital in Boston, Massachusetts. Established in 1996 in the United States, the study collects data annually from over 26,000 participants in order to evaluate the factors that influence weight change and health throughout the life cycle. The participants are children (females and males) of the women who enrolled as participants in the second cohort of the Nurses' Health Study. Established in 1976, the Nurses' Health Study has collected data from 238,000 nurse participants, making it one of the largest and longest running investigations of factors that influence women’s health and risk for disease. Combined, the Growing Up Today Study and the Nurses’ Health Study can be considered a cross-generational super-study, leading to new insights and landmark findings in the field of public health research. Early Beg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nurses Health Study
The Nurses Health Study is a series of Prospective cohort study, prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development. The studies have been among the largest investigations into risk factors for major chronic diseases ever conducted. The Nurses' Health Studies have led to many insights on health and well-being, including cancer prevention, cardiovascular disease, and Diabetes mellitus type 2, type 2 diabetes. They have included clinicians, epidemiologists, and statisticians at the Channing Laboratory (of Brigham and Women's Hospital), Harvard Medical School, Harvard School of Public Health, and several Harvard-affiliated hospitals, including Brigham and Women's Hospital, Dana–Farber Cancer Institute, Children's Hospital Boston, and Beth Israel Deaconess Medical Center. Cohorts The Nurses' Health Study original cohort was established in 1976 by Frank E. Speizer. Initi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Whole Genome Sequencing
Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondrial DNA, mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of DNA sequencing, gene sequencing at Single-nucleotide polymorphism, SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Timothy Ley
Timothy J. Ley is an American hematologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the Department of Medicine, and is chief of the Section of Stem Cell Biology in the Division of Oncology at Washington University in St. Louis. He is a member of the Alvin J. Siteman Cancer Center. Ley's research group focuses on the genetics and genomics of acute myeloid leukemia (AML). His lab studies the development of normal and leukemic blood cells. His work is focused on identifying the mutations and epigenetic events that are responsible for the initiation and progression of AML. Ley led the team that sequenced the first cancer genome (of an AML patient). He has gone on to develop projects that will use whole genome sequencing to help diagnose and treat patients with AML. To better understand the role of many of the mutations discovered through whole genome sequencing of leukemias, he and his colleagues have constructed several mouse models o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Cancer Genome Atlas
''The'' () is a grammatical article in English, denoting persons or things already mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with pronouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when followed by a consonant sound, and as (homophone of pronoun ''thee'') when followed by a v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. Symptoms may include feeling tired, shortness of breath, easy bruising and bleeding, and increased risk of infection. Occasionally, spread may occur to the brain, skin, or gums. As an acute leukemia, AML progresses rapidly, and is typically fatal within weeks or months if left untreated. Risk factors include smoking, previous chemotherapy or radiation therapy, myelodysplastic syndrome, and exposure to the chemical benzene. The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. Diagnosis is generally based on bone marrow aspiration and specific blood tests. AML has several subtypes for which treatments and outcomes may vary. The fir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endometrial Cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb). It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. The first sign is most often vaginal bleeding not associated with a menstrual period. Other symptoms include pain with urination, pain during sexual intercourse, or pelvic pain. Endometrial cancer occurs most commonly after menopause. Approximately 40% of cases are related to obesity. Endometrial cancer is also associated with excessive estrogen exposure, high blood pressure and diabetes. Whereas taking estrogen alone increases the risk of endometrial cancer, taking both estrogen and a progestogen in combination, as in most birth control pills, decreases the risk. Between two and five percent of cases are related to genes inherited from the parents. Endometrial cancer is sometimes loosely referred to as "uterine cancer", although it is distinct from other fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Samuel Achilefu
Samuel Achilefu is a Nigerian-born scientist and medical researcher who has pioneered both fundamental and applied research in science, engineering, and medicine. Dr. Samuel Achilefu is the Michel M. Ter-Pogossian Professor of Radiology and Vice Chair for Innovation and Entrepreneurship at the Mallinckrodt Institute of Radiology, Washington University School of Medicine. He holds joint appointments as a professor of medicine, biochemistry and molecular biophysics, and biomedical engineering. He currently serves as the Director of the Washington University Molecular Imaging Center and the privately funded Theranostic Innovation Program. He is co-director of thCenter for Multiple Myeloma Nanotherapyand co-Leader of thOncologic Imaging Programof the Alvin J. Siteman Cancer Center at Washington University. Achilefu is a fellow of the National Academy of Inventors as well as many professional societies, including the Royal Society of Chemistry, American Association for the Advancement ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammaglobin-A
Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the ''SCGB2A2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... Function SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans. Clinical significance SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells. References Further reading * * * * * * * * * * * * * * Human proteins {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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