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Afadin
Afadin is a protein that in humans is encoded by the ''AFDN'' gene. Function Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998). upplied by OMIMref name="entrez"> Interactions Afadin has been shown to interact with: * BCR gene, * EPHB3, * F11 receptor, * HRAS and * LMO2, * PVRL1, * PVRL3, * Profilin 1, * RAP1A, * RAP1GAP, * SORBS1, * SSX2IP Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the ''SSX2IP'' gene. It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation. The SSX2IP- ..., * Tight junction protein 1, and * USP9X. References Further reading * * * * * * * * * * * * * * * * * * * {{PDB Gallery, geneid=4301 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX2IP
Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the ''SSX2IP'' gene. It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation. The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis. Interactions SSX2IP has been initially described as a protein to interact with MLLT4 and Actinin, alpha 1 Alpha-actinin-1 is a protein that in humans is encoded by the ''ACTN1'' gene. Function Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins a .... In the context of centrosome maturation and ciliogenesis it has been shown to interact with WDR8. References Further reading * * * * * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |