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AE3
AE3 may refer to: *A size designation for Constantinian bronze coins * AE1/AE3 antibody cocktail used in immunohistochemistry * Aero Ae 04, a Czechoslovakian aircraft {{Letter-NumberCombDisambig ...
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Constantinian Bronzes
In numismatics, the term Constantinian bronzes denotes the series of bronze coins issued in the Roman Empire in the middle of the 4th century. The specific denominations are unclear and debated by historians and numismatists. They are referred to as AE1, AE2, AE3, and AE4, with the former being the largest (near 27 mm) and the latter the smallest (averaging 15 mm) in diameter: In November 2013, the largest hoard of Constantinian bronze coins was discovered in Devon, England. Called the Seaton Down Hoard, it consists of 22,000 coins, mostly Constantinian bronzes. See also *Roman currency *Follis The follis (plural ''folles''; it, follaro, ar, فلس, Fels) was a type of coin in the Roman and Byzantine traditions. Roman coin In the past, the term ''follis'' was used to describe a large bronze Roman coin introduced in about 294 (the a ... References Coins of ancient Rome Numismatics {{AncientRome-stub ...
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AE1/AE3
AE1/AE3 is an antibody cocktail that is used in immunohistochemistry, being generally positive in the cytoplasm of carcinomas (cancers of epithelial origin). Revised: 26 November 2019Cytoplasmic stain: Targets The antibody cocktail binds to cytokeratin 1 - 8, 10, 14 - 16 and 19 (but not CK17 or CK18). It is therefore used as a marker of carcinomas, such as depth of invasion and metastases. For example, it is both relatively sensitive and specific for detection of breast cancer metastasis to sentinel lymph nodes. It may cross-react with GFAP, leading to aberrant staining of glial tumors such as ependymoma, glioblastoma and schwannoma. It may also stain myofibroblasts and smooth muscle cells. Furthermore, it may stain nodal epithelial cells that has contaminated a tumor from recent biopsy. See also * List of histologic stains that aid in diagnosis of cutaneous conditions A number of histologic stains are used in the field of dermatology that aid in the diagnosis of conditions ...
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