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Augustin Nicolas Gilbert
Augustin Nicolas Gilbert (15 February 1858 – 4 March 1927) was a French physician. He was born in the town of Buzancy, Ardennes, and died in Paris. He received his doctorate from the University of Paris and became an interne at the Hôtel-Dieu de Paris. Later he was a professor of therapeutics (1902) and clinical medicine (1905) at Hôtel-Dieu. In 1907 he became a member of the ''Académie de Médecine''. He published many articles and books on a wide array of medical subjects. With Jean Alfred Fournier (1832-1914) he published ''Bibliothèque rouge de l'étudiant en médecine'', and with Paul Brouardel (1837-1906) and others, he published the multi-volume ''Traité de médecine et de Thérapeutique''. With neurologist Maurice Villaret (1877–1946), he conducted extensive research of portal hypertension. Gilbert described a hereditary cause of increased bilirubin; today this disorder is known as Gilbert's syndrome and is believed to be caused by a deficiency of the enzyme g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hôtel-Dieu 2012 43
In French-speaking countries, a hôtel-Dieu ( en, hostel of God) was originally a hospital for the poor and needy, run by the Catholic Church. Nowadays these buildings or institutions have either kept their function as a hospital, the one in Paris being the oldest and most renowned, or have been converted into hotels, museums, or general purpose buildings (for instance housing a préfecture, the administrative head office of a French department). Therefore, as a secondary meaning, the term hôtel-Dieu can also refer to the building itself, even if it no longer houses a hospital. Examples include: ;Belgium * Notre Dame à la Rose, founded in 1242 ;France *Hôtel-Dieu d'Angers, founded in 1153 *Hôtel-Dieu de Beaune, founded in 1443 *Hôtel-Dieu of Carpentras, built in 1754 *Hôtel-Dieu of Château-Thierry, founded in 1304 *Hôtel-Dieu of Cluny, built in the 17th and 18th century * Hôtel-Dieu de Lyon, created in 1478 *Hôtel-Dieu of Nantes, completed in 1508 * Hôtel-Dieu de Paris ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portal Hypertension
Portal hypertension is abnormally increased portal venous pressure – blood pressure in the portal vein and its branches, that drain from most of the intestine to the liver. Portal hypertension is defined as a hepatic venous pressure gradient greater than 5 mmHg. Cirrhosis (a form of chronic liver failure) is the most common cause of portal hypertension; other, less frequent causes are therefore grouped as non-cirrhotic portal hypertension. When it becomes severe enough to cause symptoms or complications, treatment may be given to decrease portal hypertension itself or to manage its complications. Signs and symptoms Signs and symptoms of portal hypertension include: * Ascites (free fluid in the peritoneal cavity), ** Abdominal pain or tenderness (when bacteria infect the ascites, as in spontaneous bacterial peritonitis). * Increased spleen size (splenomegaly), which may lead to lower platelet counts (thrombocytopenia) * Anorectal varices * Swollen veins on the anterior abdomin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1927 Deaths
Nineteen or 19 may refer to: * 19 (number), the natural number following 18 and preceding 20 * one of the years 19 BC, AD 19, 1919, 2019 Films * ''19'' (film), a 2001 Japanese film * ''Nineteen'' (film), a 1987 science fiction film Music * 19 (band), a Japanese pop music duo Albums * ''19'' (Adele album), 2008 * ''19'', a 2003 album by Alsou * ''19'', a 2006 album by Evan Yo * ''19'', a 2018 album by MHD * ''19'', one half of the double album ''63/19'' by Kool A.D. * ''Number Nineteen'', a 1971 album by American jazz pianist Mal Waldron * ''XIX'' (EP), a 2019 EP by 1the9 Songs * "19" (song), a 1985 song by British musician Paul Hardcastle. * "Nineteen", a song by Bad4Good from the 1992 album '' Refugee'' * "Nineteen", a song by Karma to Burn from the 2001 album ''Almost Heathen''. * "Nineteen" (song), a 2007 song by American singer Billy Ray Cyrus. * "Nineteen", a song by Tegan and Sara from the 2007 album '' The Con''. * "XIX" (song), a 2014 song by Slipk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1858 Births
Events January–March * January – **Benito Juárez (1806–1872) becomes Liberal President of Mexico. At the same time, conservatives install Félix María Zuloaga (1813–1898) as president. **William I of Prussia becomes regent for his brother, Frederick William IV, who had suffered a stroke. * January 9 ** British forces finally defeat Rajab Ali Khan of Chittagong ** Anson Jones, the last president of the Republic of Texas, commits suicide. * January 14 – Orsini affair: Felice Orsini and his accomplices fail to assassinate Napoleon III in Paris, but their bombs kill eight and wound 142 people. Because of the involvement of French émigrés living in Britain, there is a brief anti-British feeling in France, but the emperor refuses to support it. * January 25 – The ''Wedding March'' by Felix Mendelssohn becomes a popular wedding recessional, after it is played on this day at the marriage of Queen Victoria's daughter Victoria, Princess Royal, to Pri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University And State Library Düsseldorf
The University and State Library Düsseldorf (german: Universitäts- und Landesbibliothek Düsseldorf, abbreviated ULB Düsseldorf) is a central service institution of Heinrich Heine University. Along with Bonn and Münster, it is also one of the three State Libraries of North Rhine-Westphalia. Tradition and Modernity From 1965 to 1969, the University and Library Düsseldorf gradually developed out of the Medical Academy in Düsseldorf. There is no real founding year of the ULB, but the foundation stone for an integrated library system was laid when the former State and City Library of Düsseldorf was taken over by the university in 1970 and merged with the Central Library of the former Medical Academy. Structure and Holdings The ULB consists of one central library and four decentralized locations. Management and media processing are organized centrally. Catalogues, databases, e-books and e-journals are accessible throughout the whole university as well as at home via the lib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucuronosyltransferase
Uridine 5'-diphospho-glucuronosyltransferase ( UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase () that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction. ''Alternative names:'' *glucuronyltransferase *UDP-glucuronyl transferase *UDP-GT Function Glucuronosyltransferases are responsible for the process of glucuronidation, a major part of phase II metabolism. Arguably the most important of the Phase II (conjugative) enzymes, UGTs have been the subject of increasing scientific inquiry since the mid-to-late 1990s. The reaction catalyzed by the UGT enzyme involves the addition of a glucuronic acid moiety to xenobiotics and is the most important pathway for the human body's elimination of the most frequently prescribed drugs. It is also the major pathway for foreign chemical (dietary, environmental, pharmaceutical) removal for most drugs, dietary substances, toxins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gilbert's Syndrome
Gilbert syndrome (GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority. Many people never have symptoms. Occasionally jaundice (a slight yellowish color of the skin or whites of the eyes) may occur. Gilbert syndrome is due to a genetic variant in the UGT1A1 gene which results in decreased activity of the bilirubin uridine diphosphate glucuronosyltransferase enzyme. It is typically inherited in an autosomal recessive pattern and occasionally in an autosomal dominant pattern depending on the type of variant. Episodes of jaundice may be triggered by stress such as exercise, menstruation, or not eating. Diagnosis is based on higher levels of unconjugated bilirubin in the blood without either signs of other liver problems or red blood cell breakdown. Typically no treatment is needed. Gilbert syndrome is associated with decreased cardiovascular health risks. If jaundice is significant phenobarbital may be used, which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bilirubin
Bilirubin (BR) (Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged or abnormal red blood cells. In the first step of bilirubin synthesis, the heme molecule is stripped from the hemoglobin molecule. Heme then passes through various processes of porphyrin catabolism, which varies according to the region of the body in which the breakdown occurs. For example, the molecules excreted in the urine differ from those in the feces. The production of biliverdin from heme is the first major step in the catabolic pathway, after which the enzyme biliverdin reductase performs the second step, producing bilirubin from biliverdin.Boron W, Boulpaep E. Medical Physiology: a cellular and molecular approach, 2005. 984–986. Elsevier Saunders, United States. Ultimately, bilirubin is broken down within ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maurice Villaret
Maurice Villaret (7 September 1877 – 25 January 1946) was a French neurologist born in Paris. In 1906 he received his medical doctorate from the University of Paris. In 1919 he became ''médecin des hôpitaux'' in Paris, and subsequently served as ''médecin chef'' at the Hôpital Necker. In 1927 he became a professor of hydrotherapy and climatology, and in 1939 was appointed clinical professor at the Hôpital Broussais. He is remembered for his studies and experiments involving precision localization of vascular lesions of the brain. In 1917 he described what was to become known as "Villaret's syndrome". This syndrome is characterized by an ipsilateral paralysis of cranial nerve numbers IX, X, XI, XII, and sometimes cranial nerve number VII. It may also involve the cervical ganglia of the sympathetic trunk. Paralysis is caused by a lesion in the posterior retroparotid space. * Nerve IX involvement > loss of posterior taste of tongue * Nerve X involvement > Loss of sen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buzancy, Ardennes
Buzancy () is a commune in the Ardennes department and Grand Est region of north-eastern France. Population See also *Communes of the Ardennes department The following is a list of the 449 communes of the Ardennes department of France. The communes cooperate in the following intercommunalities (as of 2020):Communes of Ardennes (department) Ardennes communes articles needing translation from French Wikipedia {{Ardennes-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
