Asengeprast
Asengeprast (development code FT011) is an experimental An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs whe ... scleroderma drug candidate. It is a small molecule inhibitor of the G-protein coupled receptor GPR68 with antifibrotic activity. It is being developed by Certa Therapeutics. The European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA) has granted orphan drug status to FT011, for systemic sclerosis (SSc). Asengeprast has been reported to attenuate fibrosis and chronic heart failure in experimental diabetic cardiomyopathy. Asengeprast can also inhibit kidney fibrosis and prevent kidney failure. It was developed by structure-activity optimization of the antifibrotic activity of cinnamoyl anthranilates, by assessment of their ability to prevent TGF-beta- ...
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