Arthur M. Sackler
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Arthur M. Sackler
Arthur Mitchell Sackler (August 22, 1913 – May 26, 1987) was an American psychiatrist and marketer of pharmaceuticals whose fortune originated in medical advertising and trade publications. He was also a philanthropist and art collector. He was one of the three patriarchs of the controversial Sackler family pharmaceutical dynasty. Sackler amassed the largest personal Chinese art collection in the world, which he donated to the Smithsonian. He provided the funds needed to build numerous art galleries and schools of medicine. Sackler's estate was estimated at 140 million. Since his death, Sackler's reputation has been tarnished due to his company Purdue Pharma's central role in the opioid crisis. Many of the museums and galleries that Sackler donated to have distanced themselves from him and his family in the wake of the opioid crisis and the Sackler family's resulting reputational fall. On December 9, 2021, the Metropolitan Museum of Art in New York City officially removed the ...
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New York University
New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then-Secretary of the Treasury Albert Gallatin. In 1832, the non-denominational all-male institution began its first classes near City Hall based on a curriculum focused on a secular education. The university moved in 1833 and has maintained its main campus in Greenwich Village surrounding Washington Square Park. Since then, the university has added an engineering school in Brooklyn's MetroTech Center and graduate schools throughout Manhattan. NYU has become the largest private university in the United States by enrollment, with a total of 51,848 enrolled students, including 26,733 undergraduate students and 25,115 graduate students, in 2019. NYU also receives the most applications of any private institution in the United States and admission is considered highly selective. NYU is organized int ...
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Patrick Radden Keefe
Patrick Radden Keefe (born 1976) is an American writer and investigative journalist. He is the author of five books—''Chatter,'' ''The Snakehead,'' '' Say Nothing,'' ''Empire of Pain,'' and ''Rogues''—and has written extensively for many publications, including ''The New Yorker'', ''Slate'', and ''The New York Times Magazine''. He is a staff writer at ''The New Yorker''. Career Keefe grew up in Dorchester, Massachusetts, attended Milton Academy, and received his undergraduate degree from Columbia University in 1999. He was a resident of Schapiro Hall. He won a Marshall Scholarship in 1999, through which he received an M.Phil. in international relations from Cambridge University and an M.Sc. from the London School of Economics. After his Marshall Scholarship, Keefe returned to the U.S. and earned a J.D. degree from Yale Law School. He has since received many fellowships, including those from the Guggenheim Foundation, the Woodrow Wilson International Center for Scholars, and ...
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered in 1910, it has been considered a local hormone (autocoid) because it lacks the classic endocrine glands to secrete it; however, in recent years, histamine has been recognized as a central neurotransmitter. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is protonate ...
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Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is a psychiatry, psychiatric treatment where a generalized seizure (without muscular convulsions) is electrically induced to manage refractory mental disorders.Rudorfer, MV, Henry, ME, Sackeim, HA (2003)"Electroconvulsive therapy". In A Tasman, J Kay, JA Lieberman (eds) ''Psychiatry, Second Edition''. Chichester: John Wiley & Sons Ltd, 1865–1901. Typically, 70 to 120 volts are applied externally to the patient's head, resulting in approximately 800 amperes, milliamperes of direct current passing between the electrodes, for a duration of 100 milliseconds to 6 seconds, either from temple to temple (bilateral ECT) or from front to back of one side of the head (unilateral ECT). However, only about 1% of the electrical current crosses the bony skull into the brain because skull Electrical impedance, impedance is about 100 times higher than skin Electrical impedance, impedance. The ECT procedure was first conducted in 1938 by Italian psychiatrist Ugo C ...
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Belmont Report
The ''Belmont Report'' is a report created by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. Its full title is the ''Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research, Report of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research''. The report was issued on September 30, 1978 and published in the Federal Register on April 18, 1979. The report took its name from the Belmont Conference Center where the document was drafted in part. The Belmont Conference Center, once a part of the Smithsonian Institution, is in Elkridge, Maryland, 10 miles south of Baltimore, and until the end of 2010 was operated by Howard Community College. The ''Belmont Report'' summarizes ethical principles and guidelines for research involving human subjects. Three core principles are identified: respect for persons, beneficence, and justice. Three primary areas ...
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Declaration Of Helsinki
The Declaration of Helsinki (DoH, fi, Helsingin julistus, sv, Helsingforsdeklarationen) is a set of ethical principles regarding human experimentation developed originally in 1964 for the medical community by the World Medical Association (WMA). It is widely regarded as the cornerstone document on human research ethics. It is not a legally binding instrument under the international law, but instead draws its authority from the degree to which it has been codified in, or influenced, national or regional legislation and regulations. Its role was described by a Brazilian forum in 2000 in these words: "Even though the Declaration of Helsinki is the responsibility of the World Medical Association, the document should be considered the property of all humanity." Principles The Declaration is morally binding on physicians, and that obligation overrides any national or local laws or regulations, if the Declaration provides for a higher standard of protection of humans than the latter ...
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Nuremberg Code
The Nuremberg Code (german: Nürnberger Kodex) is a set of ethical research principles for human experimentation created by the court in '' U.S. v Brandt'', one of the Subsequent Nuremberg trials that were held after the Second World War. Though it was articulated as part of the court's verdict in the trial, the Code would later become significant beyond its original context; in a review written on the 50th anniversary of the ''Brandt'' verdict, Jay Katz writes that "a careful reading of the judgment suggests that he authorswrote the Code for the practice of human experimentation whenever it is being conducted." Background The origin of the Code began in pre–World War II German politics, particularly during the 1930s and 1940s. Starting in the mid-1920s, German physicians, usually proponents of racial hygiene, were accused by the public and the medical society of unethical medical practices. The use of racial hygiene was supported by the German government in order to promote ...
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Ultrasound
Ultrasound is sound waves with frequency, frequencies higher than the upper audible limit of human hearing range, hearing. Ultrasound is not different from "normal" (audible) sound in its physical properties, except that humans cannot hear it. This limit varies from person to person and is approximately 20 Hertz, kilohertz (20,000 hertz) in healthy young adults. Ultrasound devices operate with frequencies from 20 kHz up to several gigahertz. Ultrasound is used in many different fields. Ultrasonic devices are used to detect objects and measure distances. Ultrasound imaging or sonography is often used in medicine. In the nondestructive testing of products and structures, ultrasound is used to detect invisible flaws. Industrially, ultrasound is used for cleaning, mixing, and accelerating chemical processes. Animals such as bats and porpoises use ultrasound for locating Predation, prey and obstacles. History Acoustics, the science of sound, starts as far back as Pyth ...
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Neuroendocrinology
Neuroendocrinology is the branch of biology (specifically of physiology) which studies the interaction between the nervous system and the endocrine system; i.e. how the brain regulates the hormonal activity in the body. The nervous and endocrine systems often act together in a process called neuroendocrine integration, to regulate the physiological processes of the human body. Neuroendocrinology arose from the recognition that the brain, especially the hypothalamus, controls secretion of pituitary gland hormones, and has subsequently expanded to investigate numerous interconnections of the endocrine and nervous systems. The endocrine system consists of numerous glands throughout the body that produce and secrete hormones of diverse chemical structure, including peptides, steroids, and neuroamines. Collectively, hormones regulate many physiological processes. The neuroendocrine system is the mechanism by which the hypothalamus maintains homeostasis, regulating reproduction, metab ...
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Biological Psychiatry
Biological psychiatry or biopsychiatry is an approach to psychiatry that aims to understand mental disorder in terms of the biological Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary in ... function of the nervous system. It is interdisciplinary in its approach and draws on sciences such as neuroscience, psychopharmacology, biochemistry, genetics, epigenetics and physiology to investigate the biological bases of behavior and psychopathology. Biopsychiatry is the Specialty (medicine), branch of medicine which deals with the study of the biological function of the nervous system in mental disorders. There is some overlap with neurology, which focuses on disorders where gross or visible pathology of the nervous system is apparent, such as epilepsy, cerebral palsy, encephalitis, neuritis, ...
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Creedmoor Psychiatric Center
Creedmoor Psychiatric Center is a psychiatric hospital at 79-26 Winchester Boulevard in Queens Village, Queens, New York, United States. It provides inpatient, outpatient and residential services for severely mentally ill patients. The hospital occupies more than and includes more than 50 buildings. The site was named after the Creed family, which farmed on the site. It later was used as a firing range from the 1870s until 1892. The Farm Colony of Brooklyn State Hospital was opened on the site in 1912, with 32 patients. By 1959, the hospital housed 7,000 inpatients. The hospital's census declined by the early 1960s, and unused portions were sold off and developed into the Queens County Farm Museum, a school campus, and a children's psychiatric center. History Site The hospital's name derives from the Creeds, a family that previously farmed the site. The local railroad station on a line that ran from Long Island City to Bethpage took the name Creedmoor, apparently from th ...
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Cooper Union
The Cooper Union for the Advancement of Science and Art (Cooper Union) is a private college at Cooper Square in New York City. Peter Cooper founded the institution in 1859 after learning about the government-supported École Polytechnique in France. The school was built on a radical new model of American higher education based on Cooper's belief that an education "equal to the best technology schools established" should be accessible to those who qualify, independent of their race, religion, sex, wealth or social status, and should be "open and free to all." Cooper is considered to be one of the most prestigious colleges in the United States, with all three of its member schools consistently ranked among the highest in the country. The Cooper Union originally offered free courses to its admitted students, and when a four-year undergraduate program was established in 1902, the school granted each admitted student a full-tuition scholarship. Following its own financial crisis, ...
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