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Amurensin K
Amurensin K is an oligostilbene. It is a resveratrol tetramer found in ''Vitis amurensis''. Preliminary tests have shown it to be an effective neuraminidase inhibitor against the influenza A virus subtype H1N1 In virology, influenza A virus subtype H1N1 (A/H1N1) is a subtype of influenza A virus. Major outbreaks of H1N1 strains in humans include the Spanish flu, the 1977 Russian flu pandemic and the 2009 swine flu pandemic. It is an orthomyxovirus .... References Resveratrol oligomers Natural phenol tetramers Grape {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oligostilbene
Oligostilbenoids (oligo- or polystilbenes) are oligomeric forms of stilbenoids. Some molecules are large enough to be considered polyphenols and constitute a class of tannins. Examples Dimers * Ampelopsin A * Epsilon-viniferin * Pallidol * Quadrangularin A Trimers * α-Viniferin * Ampelopsin E * ''trans''-Diptoindonesin B * Gnetin H Tetramers * cajyphenol A * cajyphenol B * Flexuosol A * Hemsleyanol D * Hopeaphenol * Vaticanol B * R2-Viniferin (syn. Vitisin A) Modified * Diptoindonesin C can be isolated from the bark of '' Shorea pinanga'' Other * Diptoindonesin F can be isolated from the bark of ''Shorea gibbosa'' Glycosides * Diptoindonesin A Diptoindonesin A is a C- glucoside of ε-viniferin isolated from the two Dipterocarpaceae '' Shorea seminis'' and ''Dryobalanops aromatica ''Dryobalanops aromatica'', commonly known as Borneo camphor, camphor tree, Malay camphor, or Sumatran c ... References External links * {{oligostilbenoid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Resveratrol
Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts. Although commonly used as a dietary supplement and studied in laboratory models of human diseases, there is no high-quality evidence that resveratrol improves lifespan or has a substantial effect on any human disease. Research Resveratrol has been studied for its potential therapeutic use, with little evidence of anti-disease effects or health benefits in humans. Cardiovascular disease There is no evidence of benefit from resveratrol in people who already have heart disease. A 2018 meta-analysis found no effect on systolic or diastolic blood pressure; a sub-analysis revealed a 2 mmHg decrease in systolic pressure only from res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetramer (chemistry)
A tetramer () (''tetra-'', "four" + ''-mer'', "parts") is an oligomer formed from four monomers or subunits. The associated property is called ''tetramery''. An example from inorganic chemistry is titanium methoxide with the empirical formula Ti(OCH3)4, which is tetrameric in solid state and has the molecular formula Ti4(OCH3)16. An example from organic chemistry is kobophenol A, a substance that is formed by combining four molecules of resveratrol. In biochemistry, it similarly refers to a biomolecule formed of four units, that are the same ( homotetramer), i.e. as in Concanavalin A or different (heterotetramer), i.e. as in hemoglobin. Hemoglobin has 4 similar sub-units while immunoglobulins have 2 very different sub-units. The different sub-units may have each their own activity, such as binding biotin in avidin tetramers, or have a common biological property, such as the allosteric binding of oxygen in hemoglobin. See also * Cluster chemistry; atomic and molecular clu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitis Amurensis
''Vitis amurensis'', the Amur grape, is a species of grape native to the Asian continent. Its name comes from the Amur Valley in Russia and China. It is very resistant to frost, but is not tolerant to drought. Selections vary, but as a species it has strong resistance to anthracnose and ripe rot, and moderately strong resistance to downy mildew and powdery mildew. Botanical description A vine with stem 5–10 cm in diameter and typically spreading to 15–18 m, rarely up to 20–25 meters. Tendrils capable of wrapping around things will entwine the branches of neighbouring plants or anything else they can use for support. The bark is dark, scaly and with vertical stripes on old shoots. Young shoots are green, often with a reddish hue, reddish-brown in autumn. The leaves vary greatly in shape. They can be solid, three- or five-lobed, ovate or rounded, arched at the base. The size ranges from 9 to 25 cm with sharp edges and rounded-triangular serrate teeth. The surf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuraminidase Inhibitor
Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are a commonly used antiviral drug type against influenza. Viral neuraminidases are essential for influenza reproduction, facilitating viral budding from the host cell. Oseltamivir (Tamiflu), zanamivir (Relenza), laninamivir (Inavir), and peramivir belong to this class. Unlike the M2 inhibitors, which work only against the influenza A virus, NAIs act against both influenza A and influenza B. The NAIs oseltamivir and zanamivir were approved in the US and Europe for treatment and prevention of influenza A and B. Peramivir acts by strongly binding to the neuraminidase of the influenza viruses and inhibits activation of neuraminidase much longer than oseltamivir or zanamivir. However, laninamivir in the cells is slowly released into the respiratory tract, resulting in long-lasting anti-influenza virus activity. Thus the mechanism of the long-lasting activity of laninamivir is basically differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Influenza A Virus Subtype H1N1
In virology, influenza A virus subtype H1N1 (A/H1N1) is a subtype of influenza A virus. Major outbreaks of H1N1 strains in humans include the Spanish flu, the 1977 Russian flu pandemic and the 2009 swine flu pandemic. It is an orthomyxovirus that contains the glycoproteins hemagglutinin and neuraminidase. For this reason, they are described as H1N1, H1N2 etc., depending on the type of H or N antigens they express with metabolic synergy. Hemagglutinin causes red blood cells to clump together and binds the virus to the infected cell. Neuraminidase is a type of glycoside hydrolase enzyme which helps to move the virus particles through the infected cell and assist in budding from the host cells. Some strains of H1N1 are endemic in humans and cause a small fraction of all influenza-like illness and a small fraction of all seasonal influenza, for instance in 2004–2005. Other strains of H1N1 are endemic in pigs (swine influenza) and in birds (avian influenza). Its size is in dia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Resveratrol Oligomers
Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts. Although commonly used as a dietary supplement and studied in laboratory models of human diseases, there is no high-quality evidence that resveratrol improves lifespan or has a substantial effect on any human disease. Research Resveratrol has been studied for its potential therapeutic use, with little evidence of anti-disease effects or health benefits in humans. Cardiovascular disease There is no evidence of benefit from resveratrol in people who already have heart disease. A 2018 meta-analysis found no effect on systolic or diastolic blood pressure; a sub-analysis revealed a 2 mmHg decrease in systolic pressure only from r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Phenol Tetramers
Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are part of nature, human activity is often understood as a separate category from other natural phenomena. The word ''nature'' is borrowed from the Old French ''nature'' and is derived from the Latin word ''natura'', or "essential qualities, innate disposition", and in ancient times, literally meant "birth". In ancient philosophy, ''natura'' is mostly used as the Latin translation of the Greek word ''physis'' (φύσις), which originally related to the intrinsic characteristics of plants, animals, and other features of the world to develop of their own accord. The concept of nature as a whole, the physical universe, is one of several expansions of the original notion; it began with certain core applications of the word φύσις by pre-Socr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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