|
Amarogentin Gentiopicrin
Amarogentin is a chemical compound found in gentian (''Gentiana lutea'') or in ''Swertia chirata''. Gentian root has a long history of use as a herbal bitter in the treatment of digestive disorders and is an ingredient of many proprietary medicines. The bitter principles of gentian root are secoiridoid glycosides amarogentin and gentiopicrin. The former is one of the most bitter natural compounds known and is used as a scientific basis for measuring bitterness. In humans, it activates the bitter taste receptor TAS2R50. The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate and not via cinnamic or benzoic acid. It also shows an antileishmanial activity in animal model An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gentiana Lutea
''Gentiana lutea'', the great yellow gentian, is a species of gentian native to the mountains of central and southern Europe. Growth ''Gentiana lutea'' is an herbaceous perennial plant, growing to tall, with broad lanceolate to elliptic leaves long and broad. The flowers are yellow, with the corolla separated nearly to the base into 5–7 narrow petals. It grows in grassy alpine and sub-alpine pastures, usually on calcareous soils. Uses ''Gentiana lutea'' is remarkable for the intense bitterness of the root and every part of the herbage. Before the introduction of hops, gentian was used occasionally in brewing. Gentian root has a long history of use as an herbal bitter and is an ingredient of many proprietary medicines. The parts used include the dried, underground parts of the plant and the fresh, above-ground parts. The root, which can be over thick and has few branches, is harvested in the autumn and dried for later use. Caution should be exercised as to its use ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetyl-CoA
Acetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism. Its main function is to deliver the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production. Coenzyme A (CoASH or CoA) consists of a β-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3'-phosphorylated ADP. The acetyl group (indicated in blue in the structural diagram on the right) of acetyl-CoA is linked to the sulfhydryl substituent of the β-mercaptoethylamine group. This thioester linkage is a "high energy" bond, which is particularly reactive. Hydrolysis of the thioester bond is exergonic (−31.5 kJ/mol). CoA is acetylated to acetyl-CoA by the breakdown of carbohydrates through glycolysis and by the breakdown of fatty acids through β-oxidation. Acetyl-CoA then enters the citric acid cycle, where the acetyl group is oxidized to carbon dioxide and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bitter Compounds
Bitter may refer to: Common uses * Resentment, negative emotion or attitude, similar to being jaded, cynical or otherwise negatively affected by experience * Bitter (taste), one of the five basic tastes Books * ''Bitter (novel)'', a 2022 novel by Akwaeke Emezi. Food and drink * Bitter (beer), a British term for pale ale * Bitters, an herbal preparation now used mostly in cocktails Music Albums * ''Bitter'' (Jupiter Apple album), 2007 * ''Bitter'' (Meshell Ndegeocello album), 1999 Songs * "Bitter" (Fletcher song), 2020 * “Bitter” song by The Vamps from Cherry Blossom * "Bitter", 1997 single by Lit from '' Tripping the Light Fantastic'' * "Bitter", song by Jill Sobule from her 1997 album '' Happy Town'' * "Bitter", single by New Zealand band Shihad * "Bitter", song by Remy Zero from ''The Golden Hum'' * "Bitter", song by Reks from ''More Grey Hairs'' Other uses * Bitter (surname) (including a list of persons with the name) * Bitter Cars, a German car company See also * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inhibitor Of Topoisomerase I
Topoisomerase inhibitors are chemical compounds that block the action of topoisomerases, which are broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII). Topoisomerase plays important roles in cellular reproduction and DNA organization, as they mediate the cleavage of single and double stranded DNA to relax supercoils, untangle catenanes, and condense chromosomes in eukaryotic cells. Topoisomerase inhibitors influence these essential cellular processes. Some topoisomerase inhibitors prevent topoisomerases from performing DNA strand breaks while others, deemed topoisomerase poisons, associate with topoisomerase-DNA complexes and prevent the re-ligation step of the topoisomerase mechanism. These topoisomerase-DNA-inhibitor complexes are cytotoxic agents, as the un-repaired single- and double stranded DNA breaks they cause can lead to apoptosis and cell death. Because of this ability to induce apoptosis, topoisomerase inhibitors have gained int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Model
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. Animal models representing specific taxonomic groups in the research and study of developmental processes are also referred to as model organisms. There are three main types of animal models: Homologous, Isomorphic and Predictive. Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. Isomorphic animals share the same symptoms and treatments, only. Predictive models are similar to a particular human disease in only a couple of aspects. However, these are useful in isolating ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antileishmanial
Leishmaniasis is a wide array of clinical manifestations caused by parasites of the trypanosome genus '' Leishmania''. It is generally spread through the bite of phlebotomine sandflies, ''Phlebotomus'' and ''Lutzomyia'', and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe. The disease can present in three main ways: cutaneous, mucocutaneous, or visceral. The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose. The visceral form starts with skin ulcers and later presents with fever, low red blood cell count, and enlarged spleen and liver. Infections in humans are caused by more than 20 species of ''Leishmania''. Risk factors include poverty, malnutrition, deforestation, and urbanization. All three types can be diagnosed by seeing the parasites under microscopy. Additionally, visceral disease can be diagnosed by blood tests. Leishmaniasis can be par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shikimate Pathway
The shikimate pathway (shikimic acid pathway) is a seven-step metabolic pathway used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (tryptophan, phenylalanine, and tyrosine). This pathway is not found in animal cells. The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate, and ends with chorismate, a substrate for the three aromatic amino acids. The fifth enzyme involved is the shikimate kinase, an enzyme that catalyzes the ATP-dependent phosphorylation of shikimate to form shikimate 3-phosphate (shown in the figure below). Shikimate 3-phosphate is then coupled with phosphoenol pyruvate to give 5-enolpyruvylshikimate-3-phosphate via the enzyme 5-enolpyruvylshikimate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Hydroxybenzoyl-CoA
3-Hydroxybenzoyl-CoA is a molecule formed by condensing the thiol group of coenzyme A (CoA) with the carboxylic acid group of 3-hydroxybenzoic acid. Stable in acidic conditions, it is a tetraprotic acid due to the pyrophosphate and phosphate groups included. It derives from a benzoyl-CoA and a 3-hydroxybenzoic acid. In organisms such as plants, this can be formed using the 3-hydroxybenzoate—CoA ligase enzyme. This uses ATP, 3-hydroxybenzoate, and CoA as substrates. It can be reduced to 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA by reduced ferredoxin and adenosine triphosphate using the benzoyl-CoA reductase In enzymology, a benzoyl-CoA reductase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + reduced acceptor + 2 ATP + 2 H2O \rightleftharpoons cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate The 4 substrates ... enzyme. in this two hydrogen atoms are added to the benzene ring in a dearomatizing process. References {{DEFAULTS ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyketide
Polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (or reduced forms of a ketone) and methylene groups: (-CO-CH2-). First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century. In 1893, J. Norman Collie synthesized detectable amounts of orcinol by heating dehy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swertia Chirata
''Swertia'' is a genus in the gentian family containing plants sometimes referred to as the felworts. Some species bear very showy purple and blue flowers. Many members of this genus have medicinal and cultural purposes. Plants of genus ''Frasera'' are sometimes considered part of this genus, sometimes as a separate genus, and sometimes as synonymous. Selected species Species in the genus ''Swertia'' include, but are not limited to: * '' Swertia angustifolia'' Buch.-Ham. ''ex'' D. Don * ''Swertia bimaculata'' (Siebold & Zucc.) C. B. Clarke ** ''Swertia bimaculata'' (Siebold & Zucc.) Hook. f. & Thoms. * '' Swertia calcicola'' Kerr. * '' Swertia chinensis'' (Griseb.) Franch. ** '' Swertia diluta'' (Turcz.) Benth. & Hook. f. * ''Swertia chirayita'' (Roxb. ''ex'' Fleming) H. Karst. ** ''Swertia chirata'' (Wall.) C. B. Clarke * '' Swertia ciliata'' (D. Don ''ex'' G. Don) B. L. Burtt. * '' Swertia cordata'' (Wall. ''ex'' G. Don) C.B. Clarke * '' Swertia dilatata'' C. B. Clarke * '' Sw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAS2R50
Taste receptor type 2 member 50 is a protein that in humans is encoded by the ''TAS2R50'' gene. Function TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway. See also TAS2R10. See also * Taste receptor A taste receptor or tastant is a type of cellular receptor which facilitates the sensation of taste. When food or other substances enter the mouth, molecules interact with saliva and are bound to taste receptors in the oral cavity and other locat ... References Further reading * * * * * Human taste receptors {{transmembranereceptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taste Receptor
A taste receptor or tastant is a type of cellular receptor which facilitates the sensation of taste. When food or other substances enter the mouth, molecules interact with saliva and are bound to taste receptors in the oral cavity and other locations. Molecules which give a sensation of taste are considered "sapid". Vertebrate taste receptors are divided into two families: * Type 1, sweet, first characterized in 2001: – * Type 2, bitter, first characterized in 2000: In humans there are 25 known different bitter receptors, in cats there are 12, in chickens there are three, and in mice there are 35 known different bitter receptors. Visual, olfactive, "sapictive" (the perception of tastes), trigeminal (hot, cool), mechanical, all contribute to the perception of ''taste''. Of these, transient receptor potential cation channel subfamily V member 1 (TRPV1) vanilloid receptors are responsible for the perception of heat from some molecules such as capsaicin, and a CMR1 receptor is r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
