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Alderley Park
Alderley Park was a country estate at Nether Alderley, Cheshire, England, between Macclesfield and Knutsford. It was the residence of the Stanley family of Alderley from the 1500s. It became the headquarters of ICI Pharmaceuticals in the 1950s. It was purchased from AstraZeneca by Bruntwood in 2014. The site has an international reputation as a home for bio and life sciences. The Aldlerley New Hall was constructed in brick with a stone facade for Baroness Maria and John, 7th Baronet (later 1st Baron) Stanley. Building started in 1818 on a site in the south of the park. In 1931, the house was severely damaged by fire and left empty for nearly twenty years until converted in 1950 by Imperial Chemical Industries (ICI) to serve as the base for their new pharmaceutical division. The gardens and some outbuildings have been preserved and many thousands of trees planted. History The manor of Over Alderley came into the Stanley family when heiress Elizabeth Weever married John Stanley, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nether Alderley
Nether Alderley is a village and civil parish in Cheshire, England, on the A34 a mile and a half south of Alderley Edge. The civil parish includes the hamlets of Monk's Heath and Soss Moss. At Monk's Heath crossroads, the A34 crosses the A537. The AstraZeneca research laboratories at Alderley Park house 260 cancer research scientists. At the 2011 census, the population was 665. Landmarks St Mary's Church, Nether Alderley, is a Grade I listed building, described by Nickolaus Pevsner as "unexpectedly and picturesquely irregular". Nether Alderley Mill is a 16th-century watermill owned by the National Trust and designated at Grade II*. Notable residents *David Beckham and his wife, pop star Victoria Beckham, used to have a house in Nether Alderley. * Neil Hamilton and his wife Christine used to live next door to St Mary's Church in Nether Alderley. *Ole Gunnar Solskjær has a house in Nether Alderley. *Henry de Motlowe Henry de Motlowe (died 1361) was an English-born ju ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A34 Road
The A34 is a major road in England. It runs from the A33 and M3 at Winchester in Hampshire, to the A6 and A6042 in Salford, close to Manchester City Centre. It forms a large part of the major trunk route from Southampton, via Oxford, to Birmingham, The Potteries and Manchester. For most of its length (together with the A5011 and parts of the A50, and A49), it forms part of the former Winchester–Preston Trunk Road. Improvements to the section of road forming the Newbury Bypass around Newbury were the scene of significant direct action environmental protests in the 1990s. It is 151 miles (243 km) long. Route The road is in two sections. The northern section runs south through Manchester and Cheadle, and bypasses Handforth, Wilmslow and Alderley Edge, before passing through Congleton, Newcastle-under-Lyme, and the southern suburbs of Stoke-on-Trent. It then continues south via Stone, Stafford, Cannock and Walsall, passes through the middle of Birmingham (where ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cambridge
Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge became an important trading centre during the Roman and Viking ages, and there is archaeological evidence of settlement in the area as early as the Bronze Age. The first town charters were granted in the 12th century, although modern city status was not officially conferred until 1951. The city is most famous as the home of the University of Cambridge, which was founded in 1209 and consistently ranks among the best universities in the world. The buildings of the university include King's College Chapel, Cavendish Laboratory, and the Cambridge University Library, one of the largest legal deposit libraries in the world. The city's skyline is dominated by several college buildings, along with the spire of the Our Lady and the English Martyrs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta-blocker
Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage abnormal heart rhythms, and to protect the heart from a second heart attack after a first heart attack (secondary prevention). They are also widely used to treat high blood pressure, although they are no longer the first choice for initial treatment of most patients. Beta blockers are competitive antagonists that block the receptor sites for the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) on adrenergic beta receptors, of the sympathetic nervous system, which mediates the fight-or-flight response. Some block activation of all types of β-adrenergic receptors and others are selective for one of the three known types of beta receptors, designated β1, β2 and β3 receptors. β1-adrenergic receptors are located mainly in the heart and in the kidneys. β2-adrenergic receptors are located mainly in the lungs, gastrointestinal tract, liv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfred Nobel was a Swedish chemist, engineer, and industrialist most famously known for the invention of dynamite. He died in 1896. In his will, he bequeathed all of his "remaining realisable assets" to be used to establish five prizes which became known as "Nobel Prizes." Nobel Prizes were first awarded in 1901. Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace (Nobel characterized the Peace Prize as "to the person who has done the most or best to advance fellowship among nations, the abolition or reduction of standing armies, and the establishment and promotion of peace congresses"). In 1968, Sveriges Riksbank (Sweden's central bank) funded the establishment of the Prize in Economi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Black (pharmacologist)
Sir James Whyte Black (14 June 1924 – 22 March 2010) was a Scottish physician and pharmacologist. Together with Gertrude B. Elion and George H. Hitchings, he shared the Nobel Prize for Medicine in 1988 for pioneering strategies for rational drug-design, which, in his case, lead to the development of propranolol and cimetidine. Black established a Veterinary Physiology department at the University of Glasgow, where he became interested in the effects of adrenaline on the human heart. He went to work for ICI Pharmaceuticals in 1958 and, while there, developed propranolol, a beta blocker used for the treatment of heart disease. Black was also responsible for the development of cimetidine, an H2 receptor antagonist, a drug used to treat stomach ulcers. Early life and education Black was born on 14 June 1924 in Uddingston, Lanarkshire, the fourth of five sons of a Baptist family which traced its origins to Balquhidder, Perthshire. His father was a mining engineer. He was brou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Propofol
Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. It is also used for status epilepticus if other medications have not worked. It is given by injection into a vein, and the maximum effect takes about two minutes to occur and typically lasts five to ten minutes. Propofol is also used for medical assistance in dying in Canada. The medication appears to be safe for use during pregnancy but has not been well studied for use in this case. It is not recommended for use during a cesarean section. It is not a pain medication, so opioids such as morphine may also be used; however, whether or not they are always needed is not clear. Propofol is believed to work at least partly via a receptor for GABA. Propofol was discovered in 1977 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iressa
Gefitinib, sold under the brand name Iressa, is a medication used for certain breast, lung and other cancers. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR, but resistances to gefitinib can arise through other mutations. It is marketed by AstraZeneca and Teva. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. Mechanism of action Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to ina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arimidex
Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth. Common side effects of anastrozole include hot flashes, altered mood, joint pain, and nausea. Severe side effects include an increased risk of heart disease and osteoporosis. Use during pregnancy may harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the production of estrogens in the body, and hence has antiestrogenic effects. Anastrozole was patented in 1987 and was approved for medical use in 1995. It is on the World Health Organization's List of Essential Medicines. Anastrozole is available as a generic medication. In 2020, it was the 180th most commonly prescribed medication in the United States, with more than 3million prescript ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casodex
Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically used together with a gonadotropin-releasing hormone (GnRH) analogue or surgical removal of the testicles to treat advanced prostate cancer. To a lesser extent, it is used for early prostate cancer at a higher dosage as a monotherapy without castration. Bicalutamide is also used to treat excessive hair growth and scalp hair loss in women, as a component of feminizing hormone therapy for transgender women, to treat early puberty in boys, and to prevent overly long-lasting erections in men. It is taken by mouth. Common side effects in men include breast enlargement, breast tenderness, and hot flashes. Other side effects in men include feminization and sexual dysfunction. Some side effects like breast changes and feminization are minimal when combined with castration. While the medication appears to produce few side effect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zoladex
Goserelin, sold under the brand name Zoladex among others, is a medication which is used to suppress production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer. It is an injectable gonadotropin releasing hormone agonist (GnRH agonist). Structurally, it is a decapeptide. It is the natural GnRH decapeptide with two substitutions to inhibit rapid degradation. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production. It was patented in 1976 and approved for medical use in 1987. It is on the World Health Organization's List of Essential Medicines. Medical uses Goserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri-menopausal women) and prostate, and some benign gynaecological ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
