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Albert Kurland
Albert Kurland (June 29, 1914 – December 7, 2008) was a psychiatrist and Neuropsychopharmacology, neuropsychopharmacologist at the Spring Grove State Hospital and the Maryland State Psychiatric Research Center. He was also affiliated with Johns Hopkins University as a research professor. He was a prolific researcher, conducting many studies on anti-psychotics, completing early research on the treatment of alcoholics using psychedelics, and making integral contributions to the research unit at the Spring Grove State Hospital. Early life Kurland was born June 29, 1914, in Edwardsville, Pennsylvania, Edwardsville, Luzerne County, Pennsylvania to parents who had emigrated from the border Svislach, region of Poland and Belarus. He moved to Baltimore and lived with other relatives as a teenager, completing his diploma at Baltimore City College, City College Baltimore in 1932. Kurland completed his medical degree at the University of Maryland Medical School in 1940 and afterwards ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edwardsville, Pennsylvania
Edwardsville is a borough in Luzerne County, Pennsylvania, United States. The population was 4,918 at the 2020 census. History Edwardsville was first settled in 1768 by settlers from Connecticut. It was later incorporated as a borough in 1884. Geography Edwardsville is located at (41.266081, -75.908457). According to the United States Census Bureau, the borough has a total area of , of which is land and , or 2.95%, is water. The Susquehanna River makes up the borough's southern border. Transportation U.S. Route 11 is the only major highway running through Edwardsville. Demographics As of the census of 2000, there were 4,984 people, 2,345 households, and 1,280 families living in the borough. The population density was 4,233.5 people per square mile (1,630.8/km2). There were 2,587 housing units at an average density of 2,197.4 per square mile (846.5/km2). The racial makeup of the borough was 95.43% White, 2.57% African American, 0.30% Native American, 0.30% Asian, 0.36% f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maryland Psychiatric Research Center
The University of Maryland School of Medicine (abbreviated UMSOM), located in Baltimore City, Maryland, U.S., is the medical school of the University of Maryland, Baltimore and is affiliated with the University of Maryland Medical Center and University of Maryland Medical System, Medical System. Established in 1807 as the College of Medicine of Maryland, it is the first public and the fifth oldest medical school in the United States. UMB SOM's campus includes Davidge Hall, which was built in 1812, and is the oldest building in continuous use for medical education in the Northern Hemisphere. In addition to an degree, the UMB SOM offers PhD programs through the Graduate Program in Life Sciences. It also offers several joint degree programs: a Medical Scientist Training Program (MSTP) MD/PhD, a joint MD/DDS (Doctor of Dental Surgery), the MD/MPH (Master of Public Health) program, and the PhD/DPT (Doctor of Physical Therapy). The University of Maryland School of Medicine was ranked ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bupropion
Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction; it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion does, however, carry a much higher risk of seizure than many other antidepressants and extreme caution must be taken in patients with a history of seizure disorder. Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Raised blood pressure is notable. R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amoxapine
Amoxapine, sold under the brand name Asendin among others, is a tricyclic antidepressant (TCAs). It is the N-demethylated metabolite of loxapine. Amoxapine first received marketing approval in the United States in 1992 (approximately 30 to 40 years after most of the other TCAs were introduced in the United States). Medical uses Amoxapine is used in the treatment of major depressive disorder. Compared to other antidepressants it is believed to have a faster onset of action, with therapeutic effects seen within four to seven days. In excess of 80% of patients that do respond to amoxapine are reported to respond within two weeks of the beginning of treatment. It also has properties similar to those of the atypical antipsychotics, and may behave as one and may be used in the treatment of schizophrenia off-label. Despite its apparent lack of extrapyramidal side effects in patients with schizophrenia it has been found to exacerbate motor symptoms in patients with Parkinson's disease ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dilantin
Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. The intravenous form, fosphenytoin, is used for status epilepticus that does not improve with benzodiazepines. It may also be used for certain heart arrhythmias or neuropathic pain. It can be taken intravenously or by mouth. The intravenous form generally begins working within 30 minutes and is effective for roughly 24 hours. Blood levels can be measured to determine the proper dose. Common side effects include nausea, stomach pain, loss of appetite, poor coordination, increased hair growth, and enlargement of the gums. Potentially serious side effects include sleepiness, self harm, liver problems, bone marrow suppression, low blood pressure, and toxic epidermal necrolysis. There is evidence that use during pregnancy results in abnormalities ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alfetamine
Alfetamine, or alpha-allyl- phenethylamine, is a chemical compound of the phenethylamine family. It was briefly investigated as a possible antidepressant in the early 1970s. Its activity profile was said to be very similar to imipramine and amitriptyline, two tricyclic antidepressants Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants, which is important for the management of depression. They are second-line drugs next to SSRIs. TCAs were discovered in the early 1950s and wer .... It has now been largely superseded by the newer compounds in this class, and only rarely found in scientific literature. The "alpha" in its name refers to its prodrug form, alfetamine. In addition to being an antidepressant, alfetamine is also a neuroprotective agent that acts as a weak dopamine antagonist and a high affinity κ-opioid receptor agonist. Alfetamine was synthesized by Kenji Tsukada and colleagues at Shinshu University and Dow Chemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nialamide
Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity. Side effects include agitation and insomnia, less frequently dry mouth, dizziness, blurred vision, and hypomania, and rarely leukopenia and hepatitis. As with other MAOIs, a hypertensive crisis can be triggered by co-ingestion of tyramine. It is metabolized into isoniazid, an anti-tuberculosis agent, and so is contraindicated in patients with tuberculosis. The recommended dosage range is 75 to 200 mg per day, with maintenance doses as low as 12.5 mg every other day. The antiatherogenic activity of nialamide was used to design pyridinolcarbamate. See also * Hydrazine (antidepressant) The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heinz Lehmann
Heinz Edgar Lehmann (July 17, 1911 – April 7, 1999) was a German-born Canadian psychiatrist best known for his use of chlorpromazine for the treatment of schizophrenia in 1950s and "truly the father of modern psychopharmacology." Early life Born in Berlin, Germany, he was educated at the University of Freiburg, the University of Marburg, the University of Vienna, and the University of Berlin. He emigrated to Canada in 1937. Beginning his new life working at the Montreal Children's Hospital in Montreal where he improved his English until he was appointed junior psychiatrist at then Verdun Protestant Hospital, now called Douglas Mental Health University Institute, on the eve of the Second World War. He lived on the grounds of this hospital where he met his future wife Annette, a nurse, and their son François was born in 1944. Hospital work in Canada In 1947, he was appointed the clinical director of Montreal's Douglas Hospital. From 1971 to 1975, he was the chair of the Mc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jean Delay
Jean Delay (14 November 1907, Bayonne – 29 May 1987, Paris) was a French psychiatrist, neurologist, writer, and a member of the Académie française (Chair 17). His assistant Pierre Deniker conducted a test of chlorpromazine on the male mental ward where Delay worked, and the two published their findings (quickly, with what has been called academic gamesmanship) in 1952. Chlorpromazine turned out to be the first effective drug treatment for mental illness and it had a profound effect on the mentally ill and mental asylums. In 1968–1970, student revolutionaries attacked his offices, and Delay was forced into retirement from medicine. In later life, he lived as a writer. Family and education The son of Maurice Delay, a successful surgeon and mayor of Bayonne, at age fourteen Delay earned a baccalaureate in philosophy. He studied medicine in Paris. After studying in hospitals for twenty years, especially the teaching of Pierre Janet and Georges Dumas, he turned to psychiatry. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blinded Experiment
In a blind or blinded experiment, information which may influence the participants of the experiment is withheld until after the experiment is complete. Good blinding can reduce or eliminate experimental biases that arise from a participants' expectations, observer's effect on the participants, observer bias, confirmation bias, and other sources. A blind can be imposed on any participant of an experiment, including subjects, researchers, technicians, data analysts, and evaluators. In some cases, while blinding would be useful, it is impossible or unethical. For example, it is not possible to blind a patient to their treatment in a physical therapy intervention. A good clinical protocol ensures that blinding is as effective as possible within ethical and practical constraints. During the course of an experiment, a participant becomes unblinded if they deduce or otherwise obtain information that has been masked to them. For example, a patient who experiences a side effect may corr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mescaline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sources It occurs naturally in several species of cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. While religious and ceremonial peyote use was widespread in the Aztec empire and northern M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cross-tolerance
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters. Cross-tolerance has been observed with pharmaceutical drugs such as anti-anxiety agents and illicit substances, and sometimes the two of them together. Often, a person who uses one drug can be tolerant to a drug that has a completely different function.Kolb, Bryan, and Ian Whishaw. An Introduction to Brain and Behavior. New York: Worth Publishers, 2014. Print. This phenomenon allows one to become tolerant to a drug that they have never used before. Drug classifications and cross-tolerance Anxiolytics and sedatives Excitation of the GABA receptor produces an influx of negatively charged chloride ions, which hyperpolarizes the neuron and makes it less likely to give rise to an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
