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Alan Williams (immunologist)
Alan Williams FRS (25 May 1945 – 9 April 1992) was an Australian immunologist noted for his work on the identification and characterization of cell surface receptors that defined different classes of lymphocytes. Education Williams studied agricultural science at Melbourne University in Australia. From there, he went on to perform his graduate work with William Elliott on the topic of avian erythropoiesis. Career and research Following his graduate work he moved to the department of Biochemistry at the University of Oxford in the UK to perform post-doctoral studies with Professor Rodney Porter. Following the retirement of Jim Gowans in 1977, Williams took up the mantle as head of the Cellular Immunology Unit (CIU) at the Sir William Dunn School of Pathology, and was due to succeed Henry Harris as head of department before his untimely death in 1992. It was in the lab of Rodney Porter than he began the seminal work which would exemplify his career, namely the charact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rodney Porter
Prof Rodney Robert Porter, CH, FRS FRSE HFRCP (8 October 1917 – 6 September 1985) was a British biochemist and Nobel laureate. Education and early life He was born in Newton-le-Willows, Lancashire, England, the son of Joseph Lawrence Porter, chief clerk of the Railway Carriage and Wagon Works in Earlestown (Newton-le-Willows), and his wife, Isabel May Reese. He was educated at Ashton-in-Makerfield Grammar School. Rodney Robert Porter received his Bachelor of Science degree from the University of Liverpool in 1939 for Biochemistry. His career was interrupted by the Second World War during which he served as a 2nd Lieutenant in the Royal Engineers serving in Sicily and North Africa. In 1944 he was promoted to Major and transferred to the Royal Army Service Corps acting as a War Department analyst, based in Naples in Italy. After the war he moved to the University of Cambridge where he became Fred Sanger's first PhD student. He was awarded his doctorate (PhD) in 1948. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helper T Cells
The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils. CD4+ cells are mature Th cells that express the surface protein CD4. Genetic variation in regulatory elements expressed by CD4+ cells determines susceptibility to a broad class of autoimmune diseases. Structure and function Th cells contain and release cytokines to aid other immune cells. Cytokines are small protein mediators that alter the behavior of target cells that express receptors for those cytokines. These cells help polarize the immune response depending on the nature of the immunological insult ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coreceptor
A co-receptor is a cell surface receptor that binds a signalling molecule in addition to a primary receptor in order to facilitate ligand recognition and initiate biological processes, such as entry of a pathogen into a host cell. Properties The term co-receptor is prominent in literature regarding signal transduction, the process by which external stimuli regulate internal cellular functioning.Gomperts, BD.; Kramer, IM. Tatham, PER. (2002). Signal transduction. Academic Press. ISBN. The key to optimal cellular functioning is maintained by possessing specific machinery that can carry out tasks efficiently and effectively. Specifically, the process through which intermolecular reactions forward and amplify extracellular signals across the cell surface has developed to occur by two mechanisms. First, cell surface receptors can directly transduce signals by possessing both serine and threonine or simply serine in the cytoplasmic domain. They can also transmit signals through adaptor m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Georges Kohler
Georges may refer to: Places *Georges River, New South Wales, Australia *Georges Quay (Dublin) * Georges Township, Fayette County, Pennsylvania Other uses * Georges (name) * ''Georges'' (novel), a novel by Alexandre Dumas * "Georges" (song), a 1977 song originally recorded by Pat Simon and covered by Sylvie Vartan * Georges (store), a department store in Melbourne, Australia from 1880 to 1995 * Georges (''Green Card'' character) People with the surname *Eugenia Georges, American anthropologist *Karl Ernst Georges (1806–1895), German classical philologist and lexicographer, known for his edition of Latin-German dictionaries. See also *École secondaire Georges-P.-Vanier, a high school in Hamilton, Ontario, Canada *École secondaire Georges-Vanier in Laval, Quebec, Canada * French cruiser ''Georges Leygues'', commissioned in 1937 * French frigate ''Georges Leygues'' (D640), commissioned in 1979 * George (other) * Georges Creek (other) * Georges Creek Coal and Ir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hybridoma Technology
Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies). This process starts by injecting a mouse (or other mammal) with an antigen that provokes an immune response. A type of white blood cell, the B cell, produces antibodies that bind to the injected antigen. These antibody producing B-cells are then harvested from the mouse and, in turn, fused with immortal B cell cancer cells, a myeloma, to produce a hybrid cell line called a hybridoma, which has both the antibody-producing ability of the B-cell and the longevity and reproductivity of the myeloma. The hybridomas can be grown in culture, each culture starting with one viable hybridoma cell, producing cultures each of which consists of genetically identical hybridomas which produce one antibody per culture (monoclonal) rather than mixtures of different antibodies (polyclonal). The myeloma cell line that is used in this process is selected for its ability to grow i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cesar Milstein
Cesar, César or Cèsar may refer to: Arts, entertainment, and media * ''César'' (film), a 1936 film directed by Marcel Pagnol * ''César'' (play), a play by Marcel Pagnolt * César Award, a French film award Places * Cesar, Portugal * Cesar River, a river within the Magdalena Basin of Colombia * Cesar River, Chile * Cesar Department, Colombia Other uses * César (grape), an ancient red wine grape from northern Burgundy * French ship ''César'' (1768), ship of the line, destroyed 1782 * Recife Center for Advanced Studies and Systems (C.E.S.A.R), in Brazil * Cesar, a brand of dog food manufactured by Mars, Incorporated People with the given name * César (footballer, born May 1979), César Vinicio Cervo de Luca, Brazilian football centre-back * César (footballer, born July 1979), Clederson César de Souza, Brazilian football winger * César Alierta (born 1945), Spanish businessman * César Augusto Soares dos Reis Ribela (born 1995), Brazilian footballer * César Azpil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biographical Memoirs Of Fellows Of The Royal Society
The ''Biographical Memoirs of Fellows of the Royal Society'' is an academic journal on the history of science published annually by the Royal Society. It publishes obituaries of Fellows of the Royal Society. It was established in 1932 as ''Obituary Notices of Fellows of the Royal Society'' and obtained its current title in 1955, with volume numbering restarting at 1. Prior to 1932, obituaries were published in the ''Proceedings of the Royal Society''. The memoirs are a significant historical record and most include a full bibliography of works by the subjects. The memoirs are often written by a scientist of the next generation, often one of the subject's own former students, or a close colleague. In many cases the author is also a Fellow. Notable biographies published in this journal include Albert Einstein, Alan Turing, Bertrand Russell, Claude Shannon, Clement Attlee, Ernst Mayr, and Erwin Schrödinger. Each year around 40 to 50 memoirs of deceased Fellows of the Royal Soci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CD90
Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 k Da heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation. Discovery and nomenclature The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was demonstrated by them to be present on murine thymocytes, on T lymphocytes, and on neuronal cells. It was origin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
B Cells
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors. When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into an antibody-secreting effector cell, known as a plasmablast or plasma cell. Additionally, B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines. In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricius, a lymphoid organ where they were first discovered by Chang and Glick, which is why the 'B' stands for bursa and not bone marrow as commonly believed. B cells, unlike the other two classes of lymphocytes, T cells and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical messengers which bind to a receptor and cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. Receptor proteins can be classified by their location. Transmembrane receptors include ligand-gated ion channels, G protein-coupled receptors, and enzyme-linked hormone receptors. Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. A molecule that binds to a receptor is called a ligand ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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