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Alan Garen
Alan Garen was an American geneticist who co-discovered suppressor mutations for tRNA. The Garen lab also showed that certain triplet codons (5'-UAG, 5'-UAA, and 5'-UGA) failed to bind amino acids. Thus, the Garen lab and Brenner labs are both credited with discovery of the stop codons of the genetic code. Garen was a professor at Yale University between 1963 and 2021. He was a member of the National Academy of Sciences and the American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and .... References External links Garen's webpage at Yale's Dept. of Molecular Biophysics and BiochemistryAcademic genealogy of Alan Garen 1926 births 2022 deaths Members of the United States National Academy of Sciences 21st-century American biologists {{US-bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research. Yale is organized into fourteen constituent schools: the original undergraduate col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Colorado
The University of Colorado (CU) is a system of public universities in Colorado. It consists of four institutions: University of Colorado Boulder, University of Colorado Colorado Springs, University of Colorado Denver, and the University of Colorado Anschutz Medical Campus. It is governed by the elected, nine-member board of regents. Campuses * The University of Colorado Boulder (CU Boulder) is the flagship university of the University of Colorado System in Boulder, Colorado. Founded in 1876, the university has more than 33,000 undergraduate and graduate students. It offers more than 2,500 courses in more than 150 areas of study through its nine colleges and schools. * The University of Colorado Colorado Springs (UCCS) is the fastest growing of the three campuses with an undergraduate and graduate student population of about 12,000 students. It offers 45 bachelor's, 22 master's, and five doctoral degree programs through its six colleges. The campus is located in central Colorad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theodore Puck
Theodore Thomas Puck (September 24, 1916 – November 6, 2005) was an American geneticist born in Chicago, Illinois. He attended Chicago public schools and obtained his bachelors, masters, and doctoral degree from the University of Chicago. His PhD work was on the laws governing the impact of an electron upon an atom and his doctoral adviser was James Franck. During WW II Puck stayed at the University of Chicago. There he worked in the laboratory of Oswald H. Robertson on the study of how bacteria and viruses can spread through the air and on dust particles. After a postdoc position in the laboratory of Renato Dulbecco, Puck was recruited in 1948 to establish and chair the University of Colorado Medical School's department of biophysics. He retired from the University of Colorado Medical School in 1995 as professor emeritus, but continued to do laboratory work there until a few weeks before his death. Puck was an early pioneer of "somatic cell genetics" and single-cell plating ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suppressor Mutation
A suppressor mutation is a second mutation that alleviates or reverts the phenotypic effects of an already existing mutation in a process defined synthetic rescue. Genetic suppression therefore restores the phenotype seen prior to the original background mutation.Hartwell, L. H., Hood, L., Goldberg, M. L., Reynolds, A. E., Silver, L. M., & Veres, R. C. (2008). Genetics: From Genes to Genomes. New York: McGraw-Hill. Suppressor mutations are useful for identifying new genetic sites which affect a biological process of interest. They also provide evidence between functionally interacting molecules and intersecting biological pathways.Hodgkin J. Genetic suppression. 2005 Dec 27. In: WormBook: The Online Review of C. elegans Biology nternet Pasadena (CA): WormBook; 2005-. Intragenic vs. intergenic suppression Intragenic suppression Intragenic suppression results from suppressor mutations that occur in the same gene as the original mutation. In a classic study, Francis Crick (et a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TRNA
Transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length (in eukaryotes), that serves as the physical link between the mRNA and the amino acid sequence of proteins. tRNAs genes from Bacteria are typically shorter (mean = 77.6 bp) than tRNAs from Archaea (mean = 83.1 bp) and eukaryotes (mean = 84.7 bp). The mature tRNA follows an opposite pattern with tRNAs from Bacteria being usually longer (median = 77.6 nt) than tRNAs from Archaea (median = 76.8 nt), with eukaryotes exhibiting the shortest mature tRNAs (median = 74.5 nt). Transfer RNA (tRNA) does this by carrying an amino acid to the protein synthesizing machinery of a cell called the ribosome. Complementation of a 3-nucleotide codon in a messenger RNA (mRNA) by a 3-nucleotide anticodon of the tRNA results in protein synthesis based on the mRNA code. As such, tRNAs are a necessary component of translation, the biological ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Code
The genetic code is the set of rules used by living cells to translate information encoded within genetic material ( DNA or RNA sequences of nucleotide triplets, or codons) into proteins. Translation is accomplished by the ribosome, which links proteinogenic amino acids in an order specified by messenger RNA (mRNA), using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries. The codons specify which amino acid will be added next during protein biosynthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. The vast majority of genes are encoded with a single scheme (see the RNA codon table). That scheme is often referred to as the canonical or standard genetic code, or simply ''the'' genetic code, though variant codes (such as in mitochondria) exist. History Effor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts And Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a thorough petition, review, and election process. The academy's quarterly journal, ''Dædalus'', is published by MIT Press on behalf of the academy. The academy also conducts multidisciplinary public policy research. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-two incorporating fellows represented varying interests and high standing in the political, professional, and commercial secto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1926 Births
Events January * January 3 – Theodoros Pangalos (general), Theodoros Pangalos declares himself dictator in Greece. * January 8 **Abdul-Aziz ibn Saud is crowned King of Kingdom of Hejaz, Hejaz. ** Bảo Đại, Crown Prince Nguyễn Phúc Vĩnh Thuy ascends the throne, the last monarch of Vietnam. * January 12 – Freeman Gosden and Charles Correll premiere their radio program ''Sam 'n' Henry'', in which the two white performers portray two black characters from Harlem looking to strike it rich in the big city (it is a precursor to Gosden and Correll's more popular later program, ''Amos 'n' Andy''). * January 16 – A BBC comic radio play broadcast by Ronald Knox, about a workers' revolution, causes a panic in London. * January 21 – The Belgian Parliament accepts the Locarno Treaties. * January 26 – Scottish inventor John Logie Baird demonstrates a mechanical television system at his London laboratory for members of the Royal Institution and a report ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2022 Deaths
The following notable deaths occurred in 2022. Names are reported under the date of death, in alphabetical order. A typical entry reports information in the following sequence: * Name, age, country of citizenship at birth, subsequent nationality (if applicable), what subject was noted for, cause of death (if known), and reference. December 25 * Chalapathi Rao, 78, Indian actor and producer, heart attack. (death announced on this date) 24 *Vittorio Adorni, 85, Italian road racing cyclist. *Cotton Davidson, 91, American football player ( Baltimore Colts, Dallas Texans, Oakland Raiders). (death announced on this date) *Franco Frattini, 65, Italian politician and magistrate, twice minister of foreign affairs, twice of public administration, European commissioner for justice (2004–2008), cancer. *Madosini, 78, South African musician. *Barry Round, 72, Australian footballer (Sydney, Footscray, Williamstown), organ failure. *Royal Applause, 29, British Thoroughbred racehorse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Members Of The United States National Academy Of Sciences
Member may refer to: * Military jury, referred to as "Members" in military jargon * Element (mathematics), an object that belongs to a mathematical set * In object-oriented programming, a member of a class ** Field (computer science), entries in a database ** Member variable, a variable that is associated with a specific object * Limb (anatomy), an appendage of the human or animal body ** Euphemism for penis * Structural component of a truss, connected by nodes * User (computing), a person making use of a computing service, especially on the Internet * Member (geology), a component of a geological formation * Member of parliament * The Members, a British punk rock band * Meronymy, a semantic relationship in linguistics * Church membership, belonging to a local Christian congregation, a Christian denomination and the universal Church * Member, a participant in a club or learned society A learned society (; also learned academy, scholarly society, or academic association) is an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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