Adrenergic Cell Groups
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Adrenergic Cell Groups
Adrenergic cell groups refers to collections of neurons in the central nervous system that stain for PNMT, the enzyme that converts norepinephrine to epinephrine (adrenaline). Thus, it is postulated that the neurotransmitter they produce may be epinephrine (adrenaline). Located in the medulla, they are named adrenergic cell group C1, adrenergic cell group C2, and adrenergic cell group C3. See also *Noradrenergic cell groups Noradrenergic cell groups refers to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). They are named * Noradrenergic cell ... References External links * More information aBrainInfo Adrenaline {{neuroanatomy-stub ...
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PNMT
Phenylethanolamine ''N''-methyltransferase (PNMT) is an enzyme found primarily in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline). It is also expressed in small groups of neurons in the human brain and in selected populations of cardiomyocytes. Structure PNMT is a protein whose encoding gene is found on chromosome 17 in humans. It consists of 4 exons and is a 30 kDa protein. It shares many properties found among the other methyltransferases. It is closest in sequence to glycine-''N''-methyl transferase ( GNMT). It also shares many structural properties like the shape of the folding lip with catechol-O-methyl transferase (COMT), though it shares less sequence identity. Several features of the structure like this folding lip suggest that PNMT is a recent adaptation to the catecholamine synthesizing enzyme family, evolving later than COMT, but before other methyltransferases like GNMT. ''S''-adenosyl-L-methionine (SAM) is a requi ...
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Epinephrine
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an essential role in the fight-or-flight response by increasing blood flow to muscles, heart output by acting on the SA node, pupil dilation response, and blood sugar level. It does this by binding to alpha and beta receptors. It is found in many animals, including humans, and some single-celled organisms. It has also been isolated from the plant ''Scoparia dulcis'' found in Northern Vietnam. Medical uses As a medication, it is used to treat several conditions, including allergic reaction anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled adrenaline may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are not e ...
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Adrenergic Cell Group C1
Adrenergic cell group C1 is a group of cells that show evidence of phenylethanolamine N-methyltransferase (PNMT), the enzyme that converts norepinephrine to epinephrine (adrenaline); thus, they are regarded as 'putative adrenergic cells'. They are found in the ventrolateral medulla in conjunction with the noradrenergic cell group A1. The adrenergic group C1 is seen in vertebrates, including rodents and primates Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including huma .... References External links * More information aBrainInfo Adrenaline {{neuroanatomy-stub ...
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Adrenergic Cell Group C2
Adrenergic cell group C2 is a group of cells that label for PNMT, the enzyme that converts norepinephrine to epinephrine (adrenaline); thus, they are regarded as 'putative adrenergic cells'. They are found in the dorsomedial medulla in conjunction with the noradrenergic cell group A2. They are seen in vertebrates, including rodents and primates Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including huma .... References External links BrainInfo Adrenaline {{neuroanatomy-stub ...
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Adrenergic Cell Group C3
Adrenergic cell group C3 is a group of cells that label for Phenylethanolamine N-methyltransferase (PNMT), the enzyme that converts norepinephrine to epinephrine (adrenaline); thus, they are regarded as 'putative adrenergic cells'. They are found in the dorsal midline of the rostral medulla in conjunction with the noradrenergic cell group A3. Seen in rodents, group C3 is not detectable in most other species, including primates Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including huma .... References External links BrainInfo Adrenaline {{neuroanatomy-stub ...
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Noradrenergic Cell Groups
Noradrenergic cell groups refers to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). They are named * Noradrenergic cell group A1 * Noradrenergic cell group A2 * Noradrenergic cell group A4 * Noradrenergic cell group A5 * Noradrenergic cell group A6 * Noradrenergic cell group A7 Noradrenergic cell group A7 is a group of cells fluorescent for norepinephrine that is located in the pontine reticular formation ventral to the superior cerebellar peduncle of the pons The pons (from Latin , "bridge") is part of the brains ... * Noradrenergic cell group A6sc * Noradrenergic cell group Acg See also * Adrenergic cell groups References External links * More information aBrainInfo Norepinephrine {{neuroanatomy-stub ...
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